Contrasting roles for parvalbumin-expressing inhibitory neurons in two forms of adult visual cortical plasticity

Autor: Eitan S Kaplan, Sam F Cooke, Robert W Komorowski, Alexander A Chubykin, Aurore Thomazeau, Lena A Khibnik, Jeffrey P Gavornik, Mark F Bear

Publikováno v: eLife, Vol 5 (2016)

The roles played by cortical inhibitory neurons in experience-dependent plasticity are not well understood. Here we evaluate the participation of parvalbumin-expressing (PV+) GABAergic neurons in two forms of experience-dependent modification of prim

Externí odkaz: https://doaj.org/article/d5644dbadef34ef7abebf51f46762011

Delta power robustly predicts cognitive function in Angelman syndrome

Autor: Lauren M. Ostrowski, Elizabeth R. Spencer, Lynne M. Bird, Ronald Thibert, Robert W. Komorowski, Mark A. Kramer, Catherine J. Chu

Publikováno v: Annals of Clinical and Translational Neurology, Vol 8, Iss 7, Pp 1433-1445 (2021)

Abstract Objective Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by loss of function of the maternally inherited UBE3A gene in neurons. Promising disease‐modifying treatments to reinstate UBE3A expression are under developme

Externí odkaz: https://doaj.org/article/622fea4dae09436eb0c4c860814c1ba3

EEG parameters as endpoints in epilepsy clinical trials - An expert panel opinion paper

Autor: Jeffrey, Buchhalter, Caroline, Neuray, Jocelyn Y, Cheng, O'Neill, D'Cruz, Alexandre N, Datta, Dennis, Dlugos, Jacqueline, French, Dietrich, Haubenberger, Joseph, Hulihan, Pavel, Klein, Robert W, Komorowski, Lynn, Kramer, Amélie, Lothe, Rima, Nabbout, Emilio, Perucca, Peter Van, der Ark

Publikováno v: Epilepsy Research. 187:107028

The lack of ideal measurement of treatment efficacy is a well acknowledged problem in the epilepsy community, both in clinical care and clinical trials. Whilst still the current gold-standard, self-reported seizure frequency significantly underestima

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ef57b1fe4441aef87096383913beac6
https://doi.org/10.1016/j.eplepsyres.2022.107028

The Spatiotemporal Organization of Experience Dictates Hippocampal Involvement in Primary Visual Cortical Plasticity

Autor: Robert W. Komorowski, Peter S.B. Finnie, Mark F. Bear

Publikováno v: Curr Biol

The hippocampus and neocortex are theorized to be crucial partners in the formation of long-term memories. Here, we assess hippocampal involvement in two related forms of experience-dependent plasticity in the primary visual cortex (V1) of mice. Like

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::393cfcb7e217fdaf76255875cfd359fd
https://doi.org/10.2139/ssrn.3806070

Visual recognition memory, manifest as long-term habituation, requires synaptic plasticity in V1

Autor: Mark F. Bear, Sam F. Cooke, Jeffrey P. Gavornik, Eitan S. Kaplan, Robert W. Komorowski

Publikováno v: Nature neuroscience
Nat Neurosci
Cooke, S F, Komorowski, R W, Kaplan, E S, Gavornik, J P & Bear, M F 2015, ' Visual Recognition Memory, Manifested as Long-Term Habituation, Requires Synaptic Plasticity in V1 ', Nature Neuroscience, vol. 18, pp. 262-271 . https://doi.org/10.1038/nn.3920

Familiarity with stimuli that bring neither reward nor punishment, manifested through behavioral habituation, enables organisms to detect novelty and devote cognition to important elements of the environment. Here we describe in mice a form of long-t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::772a6c09cd9761a008487a1f318cbf53
http://europepmc.org/articles/PMC4383092