Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Robert W Koivula"'
Autor:
Naeimeh Atabaki-Pasdar, Mattias Ohlsson, Ana Viñuela, Francesca Frau, Hugo Pomares-Millan, Mark Haid, Angus G Jones, E Louise Thomas, Robert W Koivula, Azra Kurbasic, Pascal M Mutie, Hugo Fitipaldi, Juan Fernandez, Adem Y Dawed, Giuseppe N Giordano, Ian M Forgie, Timothy J McDonald, Femke Rutters, Henna Cederberg, Elizaveta Chabanova, Matilda Dale, Federico De Masi, Cecilia Engel Thomas, Kristine H Allin, Tue H Hansen, Alison Heggie, Mun-Gwan Hong, Petra J M Elders, Gwen Kennedy, Tarja Kokkola, Helle Krogh Pedersen, Anubha Mahajan, Donna McEvoy, Francois Pattou, Violeta Raverdy, Ragna S Häussler, Sapna Sharma, Henrik S Thomsen, Jagadish Vangipurapu, Henrik Vestergaard, Leen M 't Hart, Jerzy Adamski, Petra B Musholt, Soren Brage, Søren Brunak, Emmanouil Dermitzakis, Gary Frost, Torben Hansen, Markku Laakso, Oluf Pedersen, Martin Ridderstråle, Hartmut Ruetten, Andrew T Hattersley, Mark Walker, Joline W J Beulens, Andrea Mari, Jochen M Schwenk, Ramneek Gupta, Mark I McCarthy, Ewan R Pearson, Jimmy D Bell, Imre Pavo, Paul W Franks
Publikováno v:
PLoS Medicine, Vol 17, Iss 6, p e1003149 (2020)
BackgroundNon-alcoholic fatty liver disease (NAFLD) is highly prevalent and causes serious health complications in individuals with and without type 2 diabetes (T2D). Early diagnosis of NAFLD is important, as this can help prevent irreversible damage
Externí odkaz:
https://doaj.org/article/a99f2812d7bb4af9aa894b7e0bf320bd
Autor:
Morgan Obura, Joline W J Beulens, Roderick Slieker, Anitra D M Koopman, Trynke Hoekstra, Giel Nijpels, Petra Elders, Robert W Koivula, Azra Kurbasic, Markku Laakso, Tue H Hansen, Martin Ridderstråle, Torben Hansen, Imre Pavo, Ian Forgie, Bernd Jablonka, Hartmut Ruetten, Andrea Mari, Mark I McCarthy, Mark Walker, Alison Heggie, Timothy J McDonald, Mandy H Perry, Federico De Masi, Søren Brunak, Anubha Mahajan, Giuseppe N Giordano, Tarja Kokkola, Emmanouil Dermitzakis, Ana Viñuela, Oluf Pedersen, Jochen M Schwenk, Jurek Adamski, Harriet J A Teare, Ewan R Pearson, Paul W Franks, Leen M 't Hart, Femke Rutters, IMI-DIRECT Consortium
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0242360 (2020)
AimSubclasses of different glycaemic disturbances could explain the variation in characteristics of individuals with type 2 diabetes (T2D). We aimed to examine the association between subgroups based on their glucose curves during a five-point mixed-
Externí odkaz:
https://doaj.org/article/fa28468aa1134da49de7b42ba239579c
Autor:
Tibor V Varga, Emily Sonestedt, Dmitry Shungin, Robert W Koivula, Göran Hallmans, Stefan A Escher, Inês Barroso, Peter Nilsson, Olle Melander, Marju Orho-Melander, Frida Renström, Paul W Franks
Publikováno v:
PLoS Genetics, Vol 10, Iss 6, p e1004388 (2014)
Recent genome-wide meta-analyses identified 157 loci associated with cross-sectional lipid traits. Here we tested whether these loci associate (singly and in trait-specific genetic risk scores [GRS]) with longitudinal changes in total cholesterol (TC
Externí odkaz:
https://doaj.org/article/d2b1322a5ad04486866c197a0b2f847e
Autor:
Shafqat Ahmad, Gull Rukh, Tibor V Varga, Ashfaq Ali, Azra Kurbasic, Dmitry Shungin, Ulrika Ericson, Robert W Koivula, Audrey Y Chu, Lynda M Rose, Andrea Ganna, Qibin Qi, Alena Stančáková, Camilla H Sandholt, Cathy E Elks, Gary Curhan, Majken K Jensen, Rulla M Tamimi, Kristine H Allin, Torben Jørgensen, Soren Brage, Claudia Langenberg, Mette Aadahl, Niels Grarup, Allan Linneberg, Guillaume Paré, InterAct Consortium, DIRECT Consortium, Patrik K E Magnusson, Nancy L Pedersen, Michael Boehnke, Anders Hamsten, Karen L Mohlke, Louis T Pasquale, Oluf Pedersen, Robert A Scott, Paul M Ridker, Erik Ingelsson, Markku Laakso, Torben Hansen, Lu Qi, Nicholas J Wareham, Daniel I Chasman, Göran Hallmans, Frank B Hu, Frida Renström, Marju Orho-Melander, Paul W Franks
Publikováno v:
PLoS Genetics, Vol 9, Iss 7, p e1003607 (2013)
Numerous obesity loci have been identified using genome-wide association studies. A UK study indicated that physical activity may attenuate the cumulative effect of 12 of these loci, but replication studies are lacking. Therefore, we tested whether t
Externí odkaz:
https://doaj.org/article/50be97164e0041728ad86db2a7739c06
Autor:
Juliette A. de Klerk, Joline W. J. Beulens, Hailiang Mei, Roel Bijkerk, Anton Jan van Zonneveld, Robert W. Koivula, Petra J. M. Elders, Leen M. ’t Hart, Roderick C. Slieker
Publikováno v:
Diabetologia, 66(6), 1057-1070. Springer Verlag
de Klerk, J A, Beulens, J W J, Mei, H, Bijkerk, R, van Zonneveld, A J, Koivula, R W, Elders, P J M, ’t Hart, L M & Slieker, R C 2023, ' Altered blood gene expression in the obesity-related type 2 diabetes cluster may be causally involved in lipid metabolism : a Mendelian randomisation study ', Diabetologia, vol. 66, no. 6, pp. 1057-1070 . https://doi.org/10.1007/s00125-023-05886-8
de Klerk, J A, Beulens, J W J, Mei, H, Bijkerk, R, van Zonneveld, A J, Koivula, R W, Elders, P J M, ’t Hart, L M & Slieker, R C 2023, ' Altered blood gene expression in the obesity-related type 2 diabetes cluster may be causally involved in lipid metabolism : a Mendelian randomisation study ', Diabetologia, vol. 66, no. 6, pp. 1057-1070 . https://doi.org/10.1007/s00125-023-05886-8
Aims/hypothesis The aim of this study was to identify differentially expressed long non-coding RNAs (lncRNAs) and mRNAs in whole blood of people with type 2 diabetes across five different clusters: severe insulin-deficient diabetes (SIDD), severe ins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea52a35e62700b83debe83291a455903
https://research.vumc.nl/en/publications/c0f95e31-b148-4e23-aa6f-502a037a592e
https://research.vumc.nl/en/publications/c0f95e31-b148-4e23-aa6f-502a037a592e
Autor:
Thomas E. White, Imre Pavo, Markku Laakso, Søren Brunak, Mark I. McCarthy, Jerzy Adamski, Ana Viñuela, Femke Rutters, Anubha Mahajan, Joline W.J. Beulens, Torben Hansen, Jimmy D. Bell, Hartmut Ruetten, Robert W. Koivula, Giuseppe N. Giordano, E. Louise Thomas, Soren Brage, Naeimeh Atabaki-Pasdar, Andrea Mari, Harriet Teare, Paul W. Franks, Jochen M. Schwenk, Azra Kurbasic, Emmanouil T. Dermitzakis, Gary Frost, Ian M Forgie, Timothy J. McDonald, Federico De Masi, Ewan R. Pearson, Oluf Pedersen, Tarja Kokkola, Andrew T. Hattersley, Mark Walker, Tue H. Hansen
Publikováno v:
Koivula, R W, Atabaki-Pasdar, N, Giordano, G N, White, T, Adamski, J, Bell, J D, Beulens, J, Brage, S, Brunak, S, De Masi, F, Dermitzakis, E T, Forgie, I M, Frost, G, Hansen, T, Hansen, T H, Hattersley, A, Kokkola, T, Kurbasic, A, Laakso, M, Mari, A, McDonald, T J, Pedersen, O, Rutters, F, Schwenk, J M, Teare, H J A, Thomas, E L, Vinuela, A, Mahajan, A, McCarthy, M I, Ruetten, H, Walker, M, Pearson, E, Pavo, I, Franks, P W & IMI-DIRECT consortium 2020, ' The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes : an IMI DIRECT study ', Diabetologia, vol. 63, no. 4, pp. 744-756 . https://doi.org/10.1007/s00125-019-05083-6
Koivula, R W, Atabaki-Pasdar, N, Giordano, G N, White, T, Adamski, J, Bell, J D, Beulens, J, Brage, S, Brunak, S, De Masi, F, Dermitzakis, E T, Forgie, I M, Frost, G, Hansen, T, Hansen, T H, Hattersley, A, Kokkola, T, Kurbasic, A, Laakso, M, Mari, A, McDonald, T J, Pedersen, O, Rutters, F, Schwenk, J M, Teare, H J A, Thomas, E L, Vinuela, A, Mahajan, A, McCarthy, M I, Ruetten, H, Walker, M, Pearson, E, Pavo, I & Franks, P W 2020, ' The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes : an IMI DIRECT study ', Diabetologia, vol. 63, no. 4, pp. 744-756 . https://doi.org/10.1007/s00125-019-05083-6
Diabetologia
Diabetologia 63, 744-756 (2020)
Koivula, R W, Atabaki-Pasdar, N, Giordano, G N, White, T, Adamski, J, Bell, J D, Beulens, J, Brage, S, Brunak, S, De Masi, F, Dermitzakis, E T, Forgie, I M, Frost, G, Hansen, T, Hansen, T H, Hattersley, A, Kokkola, T, Kurbasic, A, Laakso, M, Mari, A, McDonald, T J, Pedersen, O, Rutters, F, Schwenk, J M, Teare, H J A, Thomas, E L, Vinuela, A, Mahajan, A, McCarthy, M I, Ruetten, H, Walker, M, Pearson, E, Pavo, I, Franks, P W & for the IMI DIRECT Consortium 2020, ' The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes : an IMI DIRECT study ', Diabetologia, vol. 63, no. 4, pp. 744-756 . https://doi.org/10.1007/s00125-019-05083-6
Diabetologia, 63(4), 744-756. Springer Verlag
Koivula, R W, Atabaki-Pasdar, N, Giordano, G N, White, T, Adamski, J, Bell, J D, Beulens, J, Brage, S, Brunak, S, De Masi, F, Dermitzakis, E T, Forgie, I M, Frost, G, Hansen, T, Hansen, T H, Hattersley, A, Kokkola, T, Kurbasic, A, Laakso, M, Mari, A, McDonald, T J, Pedersen, O, Rutters, F, Schwenk, J M, Teare, H J A, Thomas, E L, Vinuela, A, Mahajan, A, McCarthy, M I, Ruetten, H, Walker, M, Pearson, E, Pavo, I & Franks, P W 2020, ' The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes : an IMI DIRECT study ', Diabetologia, vol. 63, no. 4, pp. 744-756 . https://doi.org/10.1007/s00125-019-05083-6
Diabetologia
Diabetologia 63, 744-756 (2020)
Koivula, R W, Atabaki-Pasdar, N, Giordano, G N, White, T, Adamski, J, Bell, J D, Beulens, J, Brage, S, Brunak, S, De Masi, F, Dermitzakis, E T, Forgie, I M, Frost, G, Hansen, T, Hansen, T H, Hattersley, A, Kokkola, T, Kurbasic, A, Laakso, M, Mari, A, McDonald, T J, Pedersen, O, Rutters, F, Schwenk, J M, Teare, H J A, Thomas, E L, Vinuela, A, Mahajan, A, McCarthy, M I, Ruetten, H, Walker, M, Pearson, E, Pavo, I, Franks, P W & for the IMI DIRECT Consortium 2020, ' The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes : an IMI DIRECT study ', Diabetologia, vol. 63, no. 4, pp. 744-756 . https://doi.org/10.1007/s00125-019-05083-6
Diabetologia, 63(4), 744-756. Springer Verlag
Aims/hypothesis It is well established that physical activity, abdominal ectopic fat and glycaemic regulation are related but the underlying structure of these relationships is unclear. The previously proposed twin-cycle hypothesis (TC) provides a me
Autor:
Matt J. Neville, Kyriaki Pieri, Hannah Taylor, Fredrik Karpe, Eirini Trichia, Derrick A Bennett, Robert W. Koivula
Publikováno v:
Endocrine Abstracts.
Autor:
Jochen M. Schwenk, Ana Viñuela, Ian M Forgie, Hugo Pomares-Millan, Timothy J. McDonald, Andrea Mari, Jerzy Adamski, Juan Fernandez Tajes, Søren Brunak, Konstantinos D. Tsirigos, Harriet Teare, Andrea Tura, Hartmut Ruetten, E. Louise Thomas, Mattias Ohlsson, Robert W. Koivula, Federico De Masi, Henrik Vestergaard, Ramneek Gupta, Petra J. M. Elders, Giuseppe N. Giordano, Joline W. Beulens, Anubha Mahajan, Torben Hansen, Tarja Kokkola, Andrew T. Hattersley, Paul W. Franks, Alison Heggie, Martin Ridderstråle, Elizaveta Chabanova, Mark Walker, Daniel Coral, Henna Cederberg, Tue H. Hansen, Jagadish Vangipurapu, Naeimeh Atabaki-Pasdar, Leandro Z. Agudelo, Emmanouil T. Dermitzakis, Imre Pavo, Andrew A. Brown, Jimmy D. Bell, Markku Laakso, Femke Rutters, Ewan R. Pearson, Oluf Pedersen, Kristine H. Allin, Sabine van Oort, Mark I. McCarthy, Angus G. Jones, Donna McEvoy
Type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD) often co-occur. Defining causal pathways underlying this relationship may help optimize the prevention and treatment of both diseases. Thus, we assessed the strength and magnitude of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dc9e3d2f7a2b057c79495472154aa2d
https://doi.org/10.1101/2021.08.31.21262709
https://doi.org/10.1101/2021.08.31.21262709
Autor:
Anubha Mahajan, Reinhard W. Holl, Nienke van Leeuwen, Ewan R. Pearson, Leen M 't Hart, Julia C. Stingl, Simone P. Rauh, Adem Y. Dawed, Petra J. M. Elders, Kaixin Zhou, Robert W. Koivula, Neil Robertson, Paul W. Franks, Mark I. McCarthy, Angus G. Jones
Publikováno v:
Diabetes Care, 42(6), 1027-1033. American Diabetes Association Inc.
Dawed, A Y, Zhou, K, van Leeuwen, N, Mahajan, A, Robertson, N, Koivula, R, Elders, P J M, Rauh, S P, Jones, A G, Holl, R W, Stingl, J C, Franks, P W, McCarthy, M I, t Hart, L M, Pearson, E R & IMI DIRECT Consortium 2019, ' Variation in the plasma membrane monoamine transporter (PMAT) (encoded by SLC29A4) and organic cation transporter 1 (OCT1) (encoded by SLC22A1) and gastrointestinal intolerance to metformin in type 2 diabetes: An IMI direct study ', Diabetes Care, vol. 42, no. 6, pp. 1027-1033 . https://doi.org/10.2337/dc18-2182
Dawed, A Y, Zhou, K, van Leeuwen, N, Mahajan, A, Robertson, N, Koivula, R, Elders, P J M, Rauh, S P, Jones, A G, Holl, R W, Stingl, J C, Franks, P W, McCarthy, M I, t Hart, L M, Pearson, E R & IMI DIRECT Consortium 2019, ' Variation in the plasma membrane monoamine transporter (PMAT) (encoded by SLC29A4) and organic cation transporter 1 (OCT1) (encoded by SLC22A1) and gastrointestinal intolerance to metformin in type 2 diabetes: An IMI direct study ', Diabetes Care, vol. 42, no. 6, pp. 1027-1033 . https://doi.org/10.2337/dc18-2182
OBJECTIVE Gastrointestinal adverse effects occur in 20–30% of patients with metformin-treated type 2 diabetes, leading to premature discontinuation in 5–10% of the cases. Gastrointestinal intolerance may reflect localized high concentrations of m
Autor:
Petra J. M. Elders, Andrea Mari, Femke Rutters, Musholt P, Caiazzo R, Ana Viñuela, Harriet Teare, Fernandez J, H Grallert, McEvoy D, Kristine H. Allin, Pattou F, Jochen M. Schwenk, Pavo I, Mourby M, Dupuis T, Giuseppe N. Giordano, Tarja Kokkola, Andrew T. Hattersley, Adam J, Jagadish Vangipurapu, Ian M Forgie, Anubha Mahajan, Cédric Howald, Caroline Brorsson, Adamski J, Henrik Vestergaard, Gary Frost, Emmanouil T. Dermitzakis, Thomas Willum Hansen, Alison Heggie, Deborah Penet, Sapna Sharma, McDonald Tj, Mark Haid, De Masi F, Raverdy, Bernd Jablonka, Paul W. Franks, Robert W. Koivula, Andrew A. Brown, Søren Brunak, Mark I. McCarthy, Konstantinos D. Tsirigos, Angus G. Jones, Ridderstrale M, Mun-Gwan Hong, E R Pearson, Markku Laakso, Birgitte Nilsson, Davtian D, T’Hart Lm, Walker M, Oluf Pedersen, Ruetten H, Henna Cederberg, Luciana Romano
Genetic variants identified by genome-wide association studies can contribute to disease risk by altering the production and abundance of mRNA, proteins and other molecules. However, the interplay between molecular intermediaries that define the path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b140e9ddef00dc40c94154233c60821b
https://doi.org/10.1101/2021.03.26.21254347
https://doi.org/10.1101/2021.03.26.21254347