Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Robert W Hsieh"'
Autor:
Olga Generalova, Mohana Roy, Evan Hall, Sumit A. Shah, Kristen Cunanan, Touran Fardeen, Brianna Velazquez, Gilbert Chu, Bianca Bruzzone, Anna Cabot, George A. Fisher, Sandy Srinivas, Alice C. Fan, Sigurdis Haraldsdottir, Heather A. Wakelee, Joel W. Neal, Sukhmani K. Padda, Tyler Johnson, Gregory M. Heestand, Robert W. Hsieh, Kavitha Ramchandran
Publikováno v:
Journal of Patient-Reported Outcomes, Vol 5, Iss 1, Pp 1-11 (2021)
Abstract Background Patient reported outcomes (PROs) have been associated with improved symptom management and quality of life in patients with cancer. However, the implementation of PROs in an academic clinical practice has not been thoroughly descr
Externí odkaz:
https://doaj.org/article/dbafc61564464849b330b75953721f50
Autor:
Shaheen S. Sikandar, Angera H. Kuo, Tomer Kalisky, Shang Cai, Maider Zabala, Robert W. Hsieh, Neethan A. Lobo, Ferenc A. Scheeren, Sopheak Sim, Dalong Qian, Frederick M. Dirbas, George Somlo, Stephen R. Quake, Michael F. Clarke
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
The contribution of EMT in mammary gland homeostasis and human breast cancer is still unclear. Here, using in vivo lineage tracing and breast cancer PDXs the authors demonstrate that the repopulating capacity in normal mammary epithelial cells and tu
Externí odkaz:
https://doaj.org/article/f0f50f3b3e2d42029e585ebb81c7168c
Autor:
Byoung Chul Cho, Delvys Rodriguez Abreu, Maen Hussein, Manuel Cobo, Anjan J Patel, Nevena Secen, Ki Hyeong Lee, Bartomeu Massuti, Sandrine Hiret, James Chih Hsin Yang, Fabrice Barlesi, Dae Ho Lee, Luis Paz Ares, Robert W Hsieh, Namrata S Patil, Patrick Twomey, Xiaoying Yang, Raymond Meng, Melissa L Johnson
Publikováno v:
The Lancet Oncology. 23:781-792
Targeted inhibition of the PD-L1-PD-1 pathway might be further amplified through combination of PD-1 or PD-L1 inhibitors with novel anti-TIGIT inhibitory immune checkpoint agents, such as tiragolumab. In the CITYSCAPE trial, we aimed to assess the pr
Autor:
Sukhmani K. Padda, Touran Fardeen, George A. Fisher, Tyler Johnson, Gilbert Chu, Bianca Bruzzone, Brianna Velazquez, Gregory M. Heestand, Olga Generalova, Sigurdis Haraldsdottir, Sandy Srinivas, Kristen M. Cunanan, Mohana Roy, Robert W. Hsieh, Joel W. Neal, Heather A. Wakelee, Sumit A. Shah, Evan T. Hall, Anna Cabot, Kavitha Ramchandran, Alice C. Fan
Publikováno v:
Journal of Patient-Reported Outcomes
Journal of Patient-Reported Outcomes, Vol 5, Iss 1, Pp 1-11 (2021)
Journal of Patient-Reported Outcomes, Vol 5, Iss 1, Pp 1-11 (2021)
Background Patient reported outcomes (PROs) have been associated with improved symptom management and quality of life in patients with cancer. However, the implementation of PROs in an academic clinical practice has not been thoroughly described. Her
Autor:
Anjan Bharadwaj, Feiqiao Brian Yu, Robert W. Hsieh, Gunsagar S. Gulati, Aaron M. Newman, Dalong Qian, Ferenc A. Scheeren, Shang Cai, Frederick M. Dirbas, Daniel J. Wesche, Mark J. Berger, Francisco Ilagan, Michael F. Clarke, Angera H. Kuo, Maider Zabala, Neethan A. Lobo, Shaheen S. Sikandar, Anoop Manjunath
Publikováno v:
Science
Science, 367(6476), 405-+. AMER ASSOC ADVANCEMENT SCIENCE
Science, 367(6476), 405-+. AMER ASSOC ADVANCEMENT SCIENCE
Single-cell RNA-sequencing (scRNA-seq) is a powerful approach for reconstructing cellular differentiation trajectories. However, inferring both the state and direction of differentiation without prior knowledge has remained challenging. Here we descr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec50de330c26eb0f3f81a6f23c728afe
https://europepmc.org/articles/PMC7694873/
https://europepmc.org/articles/PMC7694873/
Autor:
Johanna C. Bendell, Philippe Bedard, Yung-Jue Bang, Patricia LoRusso, Stephen Hodi, Michael Gordon, Sandra D'Angelo, Jayesh Desai, Elena Garralda, Antoine Italiano, Myung-Ju Ahn, Andres Cervantes, Zev Wainberg, Emiliano Calvo, Marta Gil-Martin, Maria Martinez-Garcia, Rastilav Bahleda, Philippe Cassier, Jean-Pierre Delord, Amy Prawira, Ignacio Melero, Leisha Emens, Emanuela Romano, Karen Miller, Robert W. Hsieh, Cloris Xue, Kari Morrissey, Patrick Twomey, Kelly Gash, Namrata S. Patil, Jane Grogan, Raymond Meng, Byoung Cho, Tae Won Kim
Publikováno v:
Cancer Research. 80:CT302-CT302
Background: The immunomodulatory receptor TIGIT (T-cell Immunoreceptor with Ig and ITIM domains) is a novel inhibitory immune checkpoint present on activated T cells and NK cells in multiple cancers. In preclinical models, co-inhibition of the TIGIT
Autor:
Angera H. Kuo, George Somlo, Dalong Qian, Michael F. Clarke, Sopheak Sim, Aaron M. Newman, Tomer Kalisky, Luuk S. Heitink, Robert W. Hsieh, Shaheen S. Sikandar, Sanjay V. Malhotra, Divya Periyakoil, Jane Antony, Ajit Jadhav, Mark A. Zarnegar, Ferenc A. Scheeren, Frederick M. Dirbas
Triple-negative breast cancer (TNBC) is a poor prognosis disease with no clinically approved targeted therapies. Here, using in vitro and in vivo RNA interference (RNAi) screens in TNBC patient-derived xenografts (PDX), we identify cyclin dependent k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a8bba854deb8a3a9a8020da56e12e4
https://doi.org/10.1101/317776
https://doi.org/10.1101/317776
Autor:
Neethan A. Lobo, Sopheak Sim, Tomer Kalisky, Shang Cai, George Somlo, Dalong Qian, Angera H. Kuo, Shaheen S. Sikandar, Michael F. Clarke, Stephen R. Quake, Ferenc A. Scheeren, Frederick M. Dirbas, Maider Zabala, Robert W. Hsieh
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Nature Communications, 8
Nature Communications
Nature Communications, 8
Nature Communications
Previous studies have proposed that epithelial to mesenchymal transition (EMT) in breast cancer cells regulates metastasis, stem cell properties and chemo-resistance; most studies were based on in vitro culture of cell lines and mouse transgenic canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffbb5f5f9e413746df11c19c8a5a0b72
https://hdl.handle.net/1887/95636
https://hdl.handle.net/1887/95636
Autor:
Dennis M. Adderton, Robert W. Hsieh, Todd Sulchek, Stephen C. Minne, J. D. Adams, Calvin F. Quate
Publikováno v:
Review of Scientific Instruments. 71:2097-2099
High-speed constant force imaging with the atomic force microscope (AFM) has been achieved in liquid. By using a standard optical lever AFM, and a cantilever with an integrated zinc oxide (ZnO) piezoelectric actuator, an imaging bandwidth of 38 kHz h
Publikováno v:
Steroids. 73(1)
Conjugated equine estrogens (CEEs) are routinely used for hormone replacement therapy (HRT), making it important to understand the activities of individual estrogenic components. Although 17beta-estradiol (17beta-E2), the most potent estrogen in CEE,