Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Robert W Engelman"'
Autor:
Kiran Mahajan, Domenico Coppola, Sridevi Challa, Bin Fang, Y Ann Chen, Weiwei Zhu, Alexis S Lopez, John Koomen, Robert W Engelman, Charlene Rivera, Rebecca S Muraoka-Cook, Jin Q Cheng, Ernst Schönbrunn, Said M Sebti, H Shelton Earp, Nupam P Mahajan
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9646 (2010)
The AKT/PKB kinase is a key signaling component of one of the most frequently activated pathways in cancer and is a major target of cancer drug development. Most studies have focused on its activation by Receptor Tyrosine Kinase (RTK) mediated Phosph
Externí odkaz:
https://doaj.org/article/7f2b87878a874c4898e87e6d35f2af22
Autor:
Raki Sudan, Sandra Fernandes, Neetu Srivastava, Chiara Pedicone, Shea T. Meyer, John D. Chisholm, Robert W. Engelman, William G. Kerr
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Humans homozygous for inactivating LRBA (lipopolysaccharide (LPS)-responsive beige-like anchor) mutations or with compound heterozygous mutations exhibit a spectrum of immune-related pathologies including inflammatory bowel disease (IBD). The cause o
Externí odkaz:
https://doaj.org/article/d24cd901c8a64d47832a28c49875040d
Autor:
Jong Y. Park, Nagi Kumar, Robert W. Engelman, Ya-Yu Tsai, Junsung Choi, Arig Ibrahim Hashim, Ganna Chornokur, Heather Cornnell, Maria Rincon, Hyun Y. Park, Shahnjayla Connors, Ernest Amankwah, Seung Joon Kim
PDF file - 65K, Supplemental Figure 1. Body and prostate gland weights of C57BL/6J and TRAMP mice: A. Body weight change of C57BL/6J. B. Prostate weight of C57BL/6J. C. Body weight change of TRAMP. D. Prostate weight of TRAMP. Supplemental Figure 2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f4e143e9213e98a0105e7932af6fee2
https://doi.org/10.1158/1940-6207.22525139
https://doi.org/10.1158/1940-6207.22525139
Autor:
Jong Y. Park, Nagi Kumar, Robert W. Engelman, Ya-Yu Tsai, Junsung Choi, Arig Ibrahim Hashim, Ganna Chornokur, Heather Cornnell, Maria Rincon, Hyun Y. Park, Shahnjayla Connors, Ernest Amankwah, Seung Joon Kim
Prostate cancer treatment is often accompanied by untoward side effects. Therefore, chemoprevention to reduce the risk and inhibit the progression of prostate cancer may be an effective approach to reducing disease burden. We investigated the safety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ff9ae2b6ead3f2e146927f3f230a782
https://doi.org/10.1158/1940-6207.c.6544595
https://doi.org/10.1158/1940-6207.c.6544595
Autor:
Jong Y. Park, Nagi Kumar, Robert W. Engelman, Ya-Yu Tsai, Junsung Choi, Arig Ibrahim Hashim, Ganna Chornokur, Heather Cornnell, Maria Rincon, Hyun Y. Park, Shahnjayla Connors, Ernest Amankwah, Seung Joon Kim
PDF file - 58K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf0f281fcb17721ed8ec7bc6a763a12
https://doi.org/10.1158/1940-6207.22525142.v1
https://doi.org/10.1158/1940-6207.22525142.v1
Autor:
Natalie H Ragland, Nicole R Compo, Norman Wiltshire, Alyssa Shepard, Scott Troutman, Joseph L Kissil, Robert W Engelman
Publikováno v:
J Am Assoc Lab Anim Sci
Naked mole rats (Heterocephalus glaber) are a unique rodent species originating in Africa and are increasingly being used in research. Their needs and characteristics differ from those of other rodents used in research. Unique housing systems are nec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a23a0d2342539acac13fe80f616081b
https://europepmc.org/articles/PMC9536831/
https://europepmc.org/articles/PMC9536831/
Autor:
Narges K. Tafreshi, Haitao Ji, Robert W. Engelman, Jordan N Reff, Zhen Wang, Thaddeus J. Wadas, Alberto Chiappori, Christopher J. Tichacek, David L. Morse, Ghassan El-Haddad, Darpan N. Pandya, Mikalai M. Budzevich, David Boulware, Jonathan R. Strosberg
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 48:3408-3421
There is significant interest in the development of targeted alpha-particle therapies (TATs) for treatment of solid tumors. The metal chelator-peptide conjugate, DOTA-TATE, loaded with the β-particle emitting radionuclide 177Lu ([177Lu]Lu-DOTA-TATE)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c91d6f8d22fa2108b214d602152c043
https://doi.org/10.1007/s00259-021-05315-1
https://doi.org/10.1007/s00259-021-05315-1
Publikováno v:
Veterinary Pathology. 57:586-589
During a previously reported program-wide Corynebacterium bovis outbreak, both immunocompetent depilated ( dep/dep) mutant mice and transgenic mice that express the papillomavirus E6 oncoprotein became persistently infected with C. bovis. An orthoker
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4e4aae8823ad58f0e083cc4adb94ea7
https://doi.org/10.1177/0300985820922219
https://doi.org/10.1177/0300985820922219
Autor:
Alexis Vedder, Eric Padron, Natalie H Ragland, Emily L Miedel, Christopher Letson, Robert W. Engelman, Maria E. Balasis
Publikováno v:
Comparative Medicine
Modeling chronic myelomonocytic leukemia (CMML) in immunodeficient NSGS mice relies on unique human CMML specimens and consistent murine engraftment. Only anecdotal comments have thus far supported the notion that research data may be altered by Cory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e496f7d469c63e373073048b35c4f7
https://doi.org/10.30802/aalas-cm-18-000138
https://doi.org/10.30802/aalas-cm-18-000138
Autor:
Michael L. Langsen, Robert W. Engelman, Michael L. Doligalski, Darpan N. Pandya, Mark L. McLaughlin, Narges K. Tafreshi, David L. Morse, HyunJoo Kil, Christopher J. Tichacek, Eduardo G. Moros, Thaddeus J. Wadas, Kenneth L. Gage, John A. Vallas, David Boulware, Nella C. Delva, Mikalai M. Budzevich
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Lipophilicity is explored in the biodistribution (BD), pharmacokinetics (PK), radiation dosimetry (RD), and toxicity of an internally administered targeted alpha-particle therapy (TAT) under development for the treatment of metastat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c127ceea470c3ba7b4f9e79b33c0f87b
https://pubmed.ncbi.nlm.nih.gov/33860213
https://pubmed.ncbi.nlm.nih.gov/33860213