Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Robert W, Nickells"'
Autor:
Margaret E. Maes, Ryan J. Donahue, Cassandra L. Schlamp, Olivia J. Marola, Richard T. Libby, Robert W. Nickells
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-22 (2023)
Abstract Background Pro-apoptotic BAX is a central mediator of retinal ganglion cell (RGC) death after optic nerve damage. BAX activation occurs in two stages including translocation of latent BAX to the mitochondrial outer membrane (MOM) and then pe
Externí odkaz:
https://doaj.org/article/7657e4fe09f54146a892dfbcaf469f51
Autor:
Olivia J. Marola, Sarah E. R. Yablonski, Peter G. Shrager, Robert W. Nickells, Richard T. Libby
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-4 (2022)
Externí odkaz:
https://doaj.org/article/eb892c47a1154f999d3036c99161ddab
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-11 (2021)
Abstract Axonal degeneration of retinal ganglion cells (RGCs) causes blindness in glaucoma. Currently, there are no therapies that target axons to prevent them from degenerating. Activation of the BAX protein has been shown to be the determining step
Externí odkaz:
https://doaj.org/article/680aac1197894499b42cbfae53274c72
Publikováno v:
BMC Research Notes, Vol 14, Iss 1, Pp 1-7 (2021)
Abstract Objective Elamipretide (SS31) is a mitochondria-targeted peptide that has reported functions of stabilizing mitochondrial cristae structure and improving mitochondrial bioenergetics. Several studies have documented cell protective features o
Externí odkaz:
https://doaj.org/article/a0a3bdfe79184dedbcc355b0d9ece19c
Autor:
Nicole A. Muench, Sonia Patel, Margaret E. Maes, Ryan J. Donahue, Akihiro Ikeda, Robert W. Nickells
Publikováno v:
Cells, Vol 10, Iss 7, p 1593 (2021)
The important roles of mitochondrial function and dysfunction in the process of neurodegeneration are widely acknowledged. Retinal ganglion cells (RGCs) appear to be a highly vulnerable neuronal cell type in the central nervous system with respect to
Externí odkaz:
https://doaj.org/article/881a629da11c4c40a617383655be56e0
Autor:
Hanif Ahmad, Raid G. Alany, Jorge L. Alió, Andrew J. Anderson, Anmol Arora, Augusto Azuara-Blanco, Jorge Alio del Barrio, Christophe Baudouin, Reeda Bou Said, Rupert R.A. Bourne, Fatima Butt, David J. Calkins, Geoffrey Z.P. Chan, Ching-Yu Cheng, Rachel S. Chong, Maria Francesca Cordeiro, Jonathan G. Crowston, Qëndresë Daka, Ramin Daneshvar, Jonathan Denniss, Sundeep Singh Deol, Rebecca Epstein, Monica Ertel, Jonathan M. Fam, Ronald L. Fellman, Ted Garway-Heath, Gus Gazzard, Clare Gilbert, Kevin Gillmann, Ivan Goldberg, Jeffrey L. Goldberg, Sumit Grover, Gregg A. Heatley, Esther Hoffmann M., Alex S. Huang, Zi-Bing Jin, Murray Johnstone, Malik Kahook, L. Jay Katz, Paul L. Kaufman, Pearse A. Keane, Anthony P. Khawaja, Ziad Khoueir, Mitchell Lawlor, Christopher Leung, Boris Malyugin, Steven L. Mansberger, Kaweh Mansouri, Keith R. Martin, Christine E. Martinez, Allison M. McKendrick, André Mermoud, Robert W. Nickells, Kouros Nouri-Mahdavi, Tyler D. Oostra, Joel Palko, Radhika Pooja Patel, Zia S. Pradhan, Ramesh Priyanka, Harsha L. Rao, Reza Razeghinejad, Tony Realini, Robert Ritch, Sylvain Roy, Kerstin Sailer, Facundo G. Sanchez, Ursula Schlötzer-Schrehardt, Joel S. Schuman, Andrew Scott, Leonard Seibold, Anant Sharma, George Spaeth, Clemens A. Strohmaier, Maja Szymanska, Angelo P. Tanna, Dada Tanuj, Ian H. Tapply, Andrew J. Tatham, Carol B. Toris, Konstantinos T. Tsasousis, Ningli Wang, Robert N. Weinreb, Janey L. Wiggs, Yu Jun Wo, Gadi Wollstein, Shen Wu, Zhichao Wu, Chen Xin, Chungkwon Yoo, Cara Capitena Young, Jingxue Zhang
Publikováno v:
The Science of Glaucoma Management ISBN: 9780323884426
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::364c3377ad431d36cb4f11f6db127367
https://doi.org/10.1016/b978-0-323-88442-6.00043-1
https://doi.org/10.1016/b978-0-323-88442-6.00043-1
Autor:
Gregg A. Heatley, Robert W. Nickells
Publikováno v:
The Science of Glaucoma Management ISBN: 9780323884426
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5196fea75c1ef26dd29066fc139055b6
https://doi.org/10.1016/b978-0-323-88442-6.00018-2
https://doi.org/10.1016/b978-0-323-88442-6.00018-2
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-11 (2021)
Axonal degeneration of retinal ganglion cells (RGCs) causes blindness in glaucoma. Currently, there are no therapies that target axons to prevent them from degenerating. Activation of the BAX protein has been shown to be the determining step in the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0563af65a86fea3ef865813a52b8e7
https://doaj.org/article/680aac1197894499b42cbfae53274c72
https://doaj.org/article/680aac1197894499b42cbfae53274c72
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184434 (2017)
The pro-apoptotic BCL2 gene family member, BAX, plays a pivotal role in the intrinsic apoptotic pathway. Under cellular stress, BAX recruitment to the mitochondria occurs when activated BAX forms dimers, then oligomers, to initiate mitochondria outer
Externí odkaz:
https://doaj.org/article/6aa7dcebc00745d4bda6a5f8d4413e82
Autor:
Olivia J, Marola, Sarah E R, Yablonski, Peter G, Shrager, Robert W, Nickells, Richard T, Libby
Publikováno v:
Cell death discovery. 8(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::42f1d54f5878250b79391ac2ec7542f8
https://pubmed.ncbi.nlm.nih.gov/35869049
https://pubmed.ncbi.nlm.nih.gov/35869049