Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Robert Vries"'
Autor:
Elisa De Crignis, Tanvir Hossain, Shahla Romal, Fabrizia Carofiglio, Panagiotis Moulos, Mir Mubashir Khalid, Shringar Rao, Ameneh Bazrafshan, Monique MA Verstegen, Farzin Pourfarzad, Christina Koutsothanassis, Helmuth Gehart, Tsung Wai Kan, Robert-Jan Palstra, Charles Boucher, Jan NM IJzermans, Meritxell Huch, Sylvia F Boj, Robert Vries, Hans Clevers, Luc JW van der Laan, Pantelis Hatzis, Tokameh Mahmoudi
Publikováno v:
eLife, Vol 10 (2021)
The molecular events that drive hepatitis B virus (HBV)-mediated transformation and tumorigenesis have remained largely unclear, due to the absence of a relevant primary model system. Here we propose the use of human liver organoids as a platform for
Externí odkaz:
https://doaj.org/article/14b4dd868a334facbdb13052dadd9b22
Autor:
Annelotte M. Vonk, Peter van Mourik, Anabela S. Ramalho, Iris A.L. Silva, Marvin Statia, Evelien Kruisselbrink, Sylvia W.F. Suen, Johanna F. Dekkers, Frank P. Vleggaar, Roderick H.J. Houwen, Jasper Mullenders, Sylvia F. Boj, Robert Vries, Margarida D. Amaral, Kris de Boeck, Cornelis K. van der Ent, Jeffrey M. Beekman
Publikováno v:
STAR Protocols, Vol 1, Iss 1, Pp 100019- (2020)
Summary: This protocol describes the isolation, handling, culture of, and experiments with human colon stem cell organoids in the context of cystic fibrosis (CF). In human colon organoids, the function of cystic fibrosis transmembrane conductance reg
Externí odkaz:
https://doaj.org/article/fefd7bcad3ec46998e45178ebd7ffc13
Autor:
Nesrin Tüysüz, Louis van Bloois, Stieneke van den Brink, Harry Begthel, Monique M. A. Verstegen, Luis J. Cruz, Lijian Hui, Luc J. W. van der Laan, Jeroen de Jonge, Robert Vries, Eric Braakman, Enrico Mastrobattista, Jan J. Cornelissen, Hans Clevers, Derk ten Berge
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
There are two technical impediments for using purified Wnt proteins in serum-free stem cell cultures: rapid loss of activity and toxicity of detergents to stem cell self-renewal. Here, the authors show that lipid-stabilized Wnt3a can establish long-t
Externí odkaz:
https://doaj.org/article/c1491917e9fe4c3fa3f5944fd3318bf1
Autor:
Lars-Eric Fielmich, Annemarie Buijs, Daniele Mori, Bas Viergever, Nihed Draoui, Anna Schepers, Mariana M. Costa e Silva, Mathijs Scholtus, Tokameh Mahmoudi, Tahlita Zuiverloon, Merel Derksen, Paul Gavine, Sylvia F. Boj, Richard Meijer, Onno Kranenburg, Janine Arts, Robert Vries
Publikováno v:
Cancer Research. 83:189-189
Conventional models for preclinical drug screening offer poor predictive value for patient response, causing high attrition rates of new agents in the clinic. HUB’s proprietary Patient-Derived Organoid (PDO) Technology enables long-term expansion o
Autor:
Carla S. Verissimo, Lidwien Smabers, Emerens Wensink, Esmee Koedoot, Maarten Huismans, Celia Higuera Barón, Ricardo Korporaal, Emma Teal, Katerina-Chara Pitsa, Edwin van Oosten, Roshni Nair, Liselot Valkenburg, Geert Cirkel, Anneta Brousali, Jorieke Salij, René Overmeer, Manon Braat, Sjoerd Elias, Robert Vries, Onno Kranenburg, Miriam Koopman, Sylvia F. Boj, Jeanine Roodhart
Publikováno v:
Cancer Research. 82:4112-4112
Colorectal cancer (CRC) is the third leading cause of cancer and cancer-related death. A large fraction of the CRC patients diagnosed with de novo metastatic disease do not benefit from the standard of care but still experience substantial side effec
Forskolin-induced organoid swelling is associated with long-term cystic fibrosis disease progression
Autor:
Danya Muilwijk, Eyleen de Poel, Peter van Mourik, Sylvia W.F. Suen, Annelotte M. Vonk, Jesse E. Brunsveld, Evelien Kruisselbrink, Hugo Oppelaar, Marne C. Hagemeijer, Gitte Berkers, Karin M. de Winter-de Groot, Sabine Heida-Michel, Stephan R. Jans, Hannah van Panhuis, Menno M. van der Eerden, Renske van der Meer, Jolt Roukema, Edward Dompeling, Els J.M. Weersink, Gerard H. Koppelman, Robert Vries, Domenique D. Zomer-van Ommen, Marinus J.C. Eijkemans, Cornelis K. van der Ent, Jeffrey M. Beekman
Publikováno v:
European Respiratory Journal, 60
European Respiratory Journal, 60, 2
European Respiratory Journal, 60(2):2100508. European Respiratory Society
European respiratory journal, 60(2):2100508. European Respiratory Society
Muilwijk, D, de Poel, E, van Mourik, P, Suen, S W F, Vonk, A M, Brunsveld, J E, Kruisselbrink, E, Oppelaar, H, Hagemeijer, M C, Berkers, G, de Winter-de Groot, K M, Heida-Michel, S, Jans, S R, van Panhuis, H, van der Eerden, M M, van der Meer, R, Roukema, J, Dompeling, E, Weersink, E J M, Koppelman, G H, Vries, R, Zomer-van Ommen, D D, Eijkemans, M J C, van der Ent, C K & Beekman, J M 2022, ' Forskolin-induced organoid swelling is associated with long-term cystic fibrosis disease progression ', European Respiratory Journal, vol. 60, no. 2, 2100508 . https://doi.org/10.1183/13993003.00508-2021
European Respiratory Journal, 60, 2
European Respiratory Journal, 60(2):2100508. European Respiratory Society
European respiratory journal, 60(2):2100508. European Respiratory Society
Muilwijk, D, de Poel, E, van Mourik, P, Suen, S W F, Vonk, A M, Brunsveld, J E, Kruisselbrink, E, Oppelaar, H, Hagemeijer, M C, Berkers, G, de Winter-de Groot, K M, Heida-Michel, S, Jans, S R, van Panhuis, H, van der Eerden, M M, van der Meer, R, Roukema, J, Dompeling, E, Weersink, E J M, Koppelman, G H, Vries, R, Zomer-van Ommen, D D, Eijkemans, M J C, van der Ent, C K & Beekman, J M 2022, ' Forskolin-induced organoid swelling is associated with long-term cystic fibrosis disease progression ', European Respiratory Journal, vol. 60, no. 2, 2100508 . https://doi.org/10.1183/13993003.00508-2021
RationaleCystic fibrosis (CF) is a monogenic life-shortening disease associated with highly variable individual disease progression which is difficult to predict. Here we assessed the association of forskolin-induced swelling (FIS) of patient-derived
Autor:
Arnout G, Schepers, Robert, Vries, Maaike, van den Born, Marc, van de Wetering, Hans, Clevers
Publikováno v:
The EMBO journal. 30(6)
Somatic cells have been proposed to be limited in the number of cell divisions they can undergo. This is thought to be a mechanism by which stem cells retain their integrity preventing disease. However, we have recently discovered intestinal crypt st
Autor:
Merixtell Huch, Paola Bonfanti, Sylvia Boj, Toshiro Sato, Cindy Loomans, Marc van de Wetering, Mozhdeh Sojoodi, Vivian Li, Jurian Schuijers, Ana Gracanin, Femke Ringnalda, Harry Begthel, Karien Hamer, Joyce Mulder, Johan Van Es, Eelco De Koning, Robert Vries, Harry Heimberg, Hans Clevers
Publikováno v:
Vrije Universiteit Brussel
Lgr5 marks adult stem cells in multiple adult organs and is a receptor for the Wnt-agonistic R-spondins (RSPOs). Intestinal, stomach and liver Lgr5(+) stem cells grow in 3D cultures to form ever-expanding organoids, which resemble the tissues of orig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6f96173044cb4b1c2bf97d7051e156a7
https://researchportal.vub.be/en/publications/79e9299f-d0e3-4cc7-9136-a920a0cde5b0
https://researchportal.vub.be/en/publications/79e9299f-d0e3-4cc7-9136-a920a0cde5b0