Zobrazeno 1 - 10
of 176
pro vyhledávání: '"Robert Vassar"'
Autor:
Sohee Jeon, Miranda A. Salvo, Alia O. Alia, Jelena Popovic, Mitchell Zagardo, Sidhanth Chandra, Malik Nassan, David Gate, Robert Vassar, Leah K. Cuddy
Publikováno v:
Neurobiology of Disease, Vol 202, Iss , Pp 106729- (2024)
Angiotensin I converting enzyme (ACE1) maintains blood pressure homeostasis by converting angiotensin I into angiotensin II in the renin-angiotensin system (RAS). ACE1 is expressed in the brain, where an intrinsic RAS regulates complex cognitive func
Externí odkaz:
https://doaj.org/article/0216fb63a9dc405fbfc56f2cee57b7b3
Autor:
Rikesh M Rajani, Robert Ellingford, Mariam Hellmuth, Samuel S Harris, Orjona S Taso, David Graykowski, Francesca Kar Wey Lam, Charles Arber, Emre Fertan, John S H Danial, Matthew Swire, Marcus Lloyd, Tatiana A Giovannucci, Mathieu Bourdenx, David Klenerman, Robert Vassar, Selina Wray, Carlo Sala Frigerio, Marc Aurel Busche
Publikováno v:
PLoS Biology, Vol 22, Iss 7, p e3002727 (2024)
Reduction of amyloid beta (Aβ) has been shown to be effective in treating Alzheimer's disease (AD), but the underlying assumption that neurons are the main source of pathogenic Aβ is untested. Here, we challenge this prevailing belief by demonstrat
Externí odkaz:
https://doaj.org/article/2e71a01aa3f9400c837e535979db6d83
Autor:
Bidur Paudel, Si-Yeon Jeong, Carolina Pena Martinez, Alexis Rickman, Ashley Haluck-Kangas, Elizabeth T. Bartom, Kristina Fredriksen, Amira Affaneh, John A. Kessler, Joseph R. Mazzulli, Andrea E. Murmann, Emily Rogalski, Changiz Geula, Adriana Ferreira, Bradlee L. Heckmann, Douglas R. Green, Katherine R. Sadleir, Robert Vassar, Marcus E. Peter
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Alzheimer’s disease (AD) is characterized by progressive neurodegeneration, but the specific events that cause cell death remain poorly understood. Death Induced by Survival gene Elimination (DISE) is a cell death mechanism mediated by sho
Externí odkaz:
https://doaj.org/article/64dd0289c30a4bcf9ae00fb8857f2f61
Autor:
Arun Upadhyay, Deepak Chhangani, Nalini R. Rao, Julia Kofler, Robert Vassar, Diego E. Rincon-Limas, Jeffrey N. Savas
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-22 (2023)
Abstract Background The accumulation of amyloid beta (Aβ) peptides in fibrils is prerequisite for Alzheimer’s disease (AD). Our understanding of the proteins that promote Aβ fibril formation and mediate neurotoxicity has been limited due to techn
Externí odkaz:
https://doaj.org/article/7eaac55008754edf8e7f07da3c74bf5d
Autor:
Sidhanth Chandra, Antonio Di Meco, Hemraj B. Dodiya, Jelena Popovic, Leah K. Cuddy, Ian Q. Weigle, Xiaoqiong Zhang, Katherine Sadleir, Sangram S. Sisodia, Robert Vassar
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-29 (2023)
Abstract Background Previous studies show that antibiotic-mediated (abx) alteration of the gut microbiome (GMB) results in a reduction of amyloid beta (Aβ) plaques and proinflammatory microglial phenotype in male APPPS1-21 mice. However, the effect
Externí odkaz:
https://doaj.org/article/fe6496ac0b6f408daa41cca488989bdf
Autor:
Alia O. Alia, Sohee Jeon, Jelena Popovic, Miranda A. Salvo, Katherine R. Sadleir, Robert Vassar, Leah K. Cuddy
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Current scientific research is driven by the ability to manipulate gene expression by utilizing the Cre/loxP system in transgenic mouse models. However, artifacts in Cre-driver mouse lines that introduce undesired effects and confound result
Externí odkaz:
https://doaj.org/article/167aa54b5aac49f5b0590a07a00301e3
Autor:
Justyna A. Dobrowolska Zakaria, Randall J. Bateman, Monika Lysakowska, Ammaarah Khatri, Dinorah Jean-Gilles, Matthew E. Kennedy, Robert Vassar
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Evidence suggests that β-secretase (BACE1), which cleaves Amyloid Precursor Protein (APP) to form sAPPβ and amyloid-β, is elevated in Alzheimer's disease (AD) brains and biofluids and, thus, BACE1 is a therapeutic target for this devastat
Externí odkaz:
https://doaj.org/article/e920bdebd0534dcca97073affc0fb225
Autor:
Katherine R. Sadleir, Robert Vassar
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 14 (2023)
In this issue of the JCI, Wang and colleagues investigate the relationship between sleep disturbances, an environmental risk factor for Alzheimer’s disease (AD), and the apolipoprotein 4 (APOEε4) allele, a strong genetic risk factor for AD. The au
Externí odkaz:
https://doaj.org/article/bda30faeb2444e4091c29e4556298721
Autor:
Leah K. Cuddy, Alia O. Alia, Miranda A. Salvo, Sidhanth Chandra, Tom N. Grammatopoulos, Craig J. Justman, Peter T. Lansbury, Joseph R. Mazzulli, Robert Vassar
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-23 (2022)
Abstract Background Amyloid plaque deposition and axonal degeneration are early events in AD pathogenesis. Aβ disrupts microtubules in presynaptic dystrophic neurites, resulting in the accumulation of impaired endolysosomal and autophagic organelles
Externí odkaz:
https://doaj.org/article/e44cfb2c142247068fdf496e4be970c6
Autor:
Alexis R. Demonbreun, Elena Bogdanovic, Lauren A. Vaught, Nina L. Reiser, Katherine S. Fallon, Ashlee M. Long, Claire C. Oosterbaan, Michele Hadhazy, Patrick G.T. Page, Prem Raj B. Joseph, Gabrielle Cowen, Alexander M. Telenson, Ammaarah Khatri, Katherine R. Sadleir, Robert Vassar, Elizabeth M. McNally
Publikováno v:
JCI Insight, Vol 7, Iss 14 (2022)
Membrane instability and disruption underlie myriad acute and chronic disorders. Anxa6 encodes the membrane-associated protein annexin A6 and was identified as a genetic modifier of muscle repair and muscular dystrophy. To evaluate annexin A6’s rol
Externí odkaz:
https://doaj.org/article/a65dd117d9c34bac932013e4dc593d52