Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Robert Vácha"'
Autor:
Katerina Linhartova, Francesco Luca Falginella, Martin Matl, Marek Sebesta, Robert Vácha, Richard Stefl
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The intrinsically disordered carboxy-terminal domain (CTD) of the largest subunit of RNA Polymerase II (RNAPII) consists of multiple tandem repeats of the consensus heptapeptide Y1-S2-P3-T4-S5-P6-S7. The CTD promotes liquid-liquid phase-sepa
Externí odkaz:
https://doaj.org/article/c89a2875d34c461db455c1f2a4eeae34
Autor:
Denys Biriukov, Robert Vácha
Publikováno v:
ACS Physical Chemistry Au, Vol 4, Iss 4, Pp 302-313 (2024)
Externí odkaz:
https://doaj.org/article/102cd1c169394cc3bff99c5b6bb74268
Autor:
Helene Jahn, Ladislav Bartoš, Grace I. Dearden, Jeremy S. Dittman, Joost C. M. Holthuis, Robert Vácha, Anant K. Menon
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Mitochondria are double-membrane-bounded organelles that depend critically on phospholipids supplied by the endoplasmic reticulum. These lipids must cross the outer membrane to support mitochondrial function, but how they do this is unclear.
Externí odkaz:
https://doaj.org/article/80090a11e13246b496e3a818de0be8af
Autor:
Miroslav Jurásek, Jitender Kumar, Petra Paclíková, Alka Kumari, Konstantinos Tripsianes, Vítězslav Bryja, Robert Vácha
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract The PDZ domain of Dishevelled 3 protein belongs to a highly abundant protein recognition motif which typically binds short C-terminal peptides. The affinity of the PDZ towards the peptides could be fine-tuned by a variety of post-translation
Externí odkaz:
https://doaj.org/article/69a71e109e3e4b98bed52b98a56b9089
Autor:
Jakub Harnoš, Maria Consuelo Alonso Cañizal, Miroslav Jurásek, Jitender Kumar, Cornelia Holler, Alexandra Schambony, Kateřina Hanáková, Ondřej Bernatík, Zbyněk Zdráhal, Kristína Gömöryová, Tomáš Gybeľ, Tomasz Witold Radaszkiewicz, Marek Kravec, Lukáš Trantírek, Jan Ryneš, Zankruti Dave, Ana Iris Fernández-Llamazares, Robert Vácha, Konstantinos Tripsianes, Carsten Hoffmann, Vítězslav Bryja
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Dishevelled (DVL) is the key component of Wnt signaling pathway that acts as a signaling hub. Here, authors study the conformational dynamics of DVL3 in vivo using their engineered FlAsH-based FRET biosensors and describe how Wnt activation opens DVL
Externí odkaz:
https://doaj.org/article/c656ec6d84244ea4ba47e39232d91995
Autor:
David Buchta, Tibor Füzik, Dominik Hrebík, Yevgen Levdansky, Lukáš Sukeník, Liya Mukhamedova, Jana Moravcová, Robert Vácha, Pavel Plevka
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Genome release of enteroviruses relies on exposure to acidic pH, but the mechanism of uncoating remains unclear. Here, Buchta et al. show that echovirus 18 loses one to three adjacent capsid-protein pentamers, resulting in an opening of more than 120
Externí odkaz:
https://doaj.org/article/2dfed097c8834689b127851bd87cfefd
Publikováno v:
International Journal of Biomedicine, Vol 11, Iss Suppl_1, Pp 9-10 (2021)
Protein capsids protect the genomes of viruses from degradation in the extracellular environment. However, virus capsids must release genomes into a host cell to initiate infection. We used cryo-electron microscopy to characterize the genome release
Externí odkaz:
https://doaj.org/article/12c99e02cb204984bfcc4f4ae7db2dfe
Autor:
Alzbeta Tuerkova, Ivo Kabelka, Tereza Králová, Lukáš Sukeník, Šárka Pokorná, Martin Hof, Robert Vácha
Publikováno v:
eLife, Vol 9 (2020)
Every cell is protected by a semipermeable membrane. Peptides with the right properties, for example Antimicrobial peptides (AMPs), can disrupt this protective barrier by formation of leaky pores. Unfortunately, matching peptide properties with their
Externí odkaz:
https://doaj.org/article/1d109efe403f427794d37ce9da3fc4ec
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 8350 (2021)
DivIVA is a protein initially identified as a spatial regulator of cell division in the model organism Bacillus subtilis, but its homologues are present in many other Gram-positive bacteria, including Clostridia species. Besides its role as topologic
Externí odkaz:
https://doaj.org/article/7033de91fed24c95bfc2c57e23bab348
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 10, p e1002692 (2012)
The pre-fibrillar stages of amyloid formation have been implicated in cellular toxicity, but have proved to be challenging to study directly in experiments and simulations. Rational strategies to suppress the formation of toxic amyloid oligomers requ
Externí odkaz:
https://doaj.org/article/b0b92e549d49468ca71606453f614e20