Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Robert V. O'Brien"'
Autor:
Maureen E. Hillenmeyer, Gergana A. Vandova, Robert V. O’Brien, Curt R. Fischer, Brian Lowry, Chaitan Khosla, Thomas Robbins, Ronald W. Davis, Colin J. B. Harvey
Publikováno v:
The Journal of Antibiotics
Heterologous expression of diverse propionyl-CoA carboxylases affects polyketide production in Escherichia coli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a51c91110b23211148e0ea07af85e14e
https://doi.org/10.1038/ja.2017.38
https://doi.org/10.1038/ja.2017.38
Publikováno v:
Journal of the American Chemical Society
Journal of the American Chemical Society, vol 136, iss 46
Journal of the American Chemical Society, vol 136, iss 46
A convergent diastereo- and enantioselective total synthesis of anticancer and antifungal macrocyclic natural product disorazole C1 is reported. The central feature of the successful route is the application of catalytic Z-selective cross-metathesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84d5f3cc5bacc119976c9d96fa90ffe4
https://doi.org/10.1021/ja509973r
https://doi.org/10.1021/ja509973r
Publikováno v:
Angewandte Chemie. 125:7238-7265
Frei vorkommende nichtproteinogene Aminosauren sind schon lange wegen ihrer antimetabolen Eigenschaften bekannt. Entdeckt werden sie meist aufgrund der Reaktivitat gegenuber der katalytischen Wirkung der Zielenzyme. Fuhrt man sie regiospezifisch in b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c4fb81957667460d4a07addc3e086c8
https://doi.org/10.1002/ange.201208344
https://doi.org/10.1002/ange.201208344
Publikováno v:
Journal of the American Chemical Society. 134:12774-12779
The first instances of Z- and enantioselective Ru-catalyzed olefin metathesis are presented. Ring-opening/cross-metathesis (ROCM) reactions of oxabicyclic alkenes and enol ethers and a phenyl vinyl sulfide are promoted by 0.5–5.0 mol % of enantiome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b0548f5be78124a30309b91743fab3c
https://doi.org/10.1021/ja304827a
https://doi.org/10.1021/ja304827a
Autor:
Sebastian Torker, Pamela J. Lombardi, Adil R. Zhugralin, R. Kashif M. Khan, Robert V. O’Brien, Amir H. Hoveyda
Publikováno v:
Journal of the American Chemical Society. 134:12438-12441
The synthesis, isolation, purification (routine silica gel chromatography), and spectroscopic characterization of high-energy endo stereogenic-at-Ru complex isomers, generated by ring-opening/cross-metathesis (ROCM) reaction of the corresponding exo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb9fc9af4e3dc9d25dd85744416db447
https://doi.org/10.1021/ja3056722
https://doi.org/10.1021/ja3056722
Publikováno v:
Nature
Alkenes are found in many biologically active molecules, and there are a large number of chemical transformations in which alkenes act as the reactants or products (or both) of the reaction. Many alkenes exist as either the E or the higher-energy Z s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff011ddc3345eead9a422df437d5ed9
https://doi.org/10.1038/nature09957
https://doi.org/10.1038/nature09957
Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins
Autor:
Damaris Bausch-Fluck, Ruedi Aebersold, Ralph Schiess, Julian D. Watts, Miriam Bibel, Bernd Wollscheid, Christine Henderson, Robert V. O’Brien
Publikováno v:
Nature Biotechnology. 27:378-386
Although the classification of cell types often relies on the identification of cell surface proteins as differentiation markers, flow cytometry requires suitable antibodies and currently permits detection of only up to a dozen differentiation marker
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c85e2ff8d03eae10e0a61a4d5207967
https://doi.org/10.1038/nbt.1532
https://doi.org/10.1038/nbt.1532
Publikováno v:
ChemInform. 46
The diastereo- and enantioselective preparation of the macrocyclic natural product (IV) with anticancer and antifungal activities is described which comprises the title reaction as a key step.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96e5925d4b68f9bb83106910bd751d62
https://doi.org/10.1002/chin.201521236
https://doi.org/10.1002/chin.201521236
The increasing availability of DNA sequence data offers an opportunity for identifying new assembly-line polyketide synthases (PKSs) that produce biologically active natural products. We developed an automated method to extract and consolidate all mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf6021a35c5f66e1cde5bb2427ac7d7
https://europepmc.org/articles/PMC4028714/
https://europepmc.org/articles/PMC4028714/
Autor:
David E. Cane, Chaitan Khosla, Brian Lowry, Chih-Hisang Weng, Thomas Robbins, Robert V. O’Brien
Notwithstanding an extensive literature on assembly line polyketide synthases such as the 6-deoxyerythronolide B synthase (DEBS), a complete naturally occurring synthase has never been reconstituted in vitro from purified protein components. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e68254ba63018860697d327a7ebe070c
https://europepmc.org/articles/PMC3858836/
https://europepmc.org/articles/PMC3858836/