Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Robert V. Bundick"'
Autor:
Henrik Ekberg, Zhongquan Qi, Agneta Montgomery, Elain Holness, David Donald, Robert I. Craggs, Clara Paul, Susan Edwards, Clare Murray, Robert V. Bundick
Publikováno v:
Trends in Transplantation. 11
Autor:
Clara Påhlman, Clare Murray, David Donald, Zhongquan Qi, Henrik Ekberg, Douglas Ferguson, Robert V. Bundick
Publikováno v:
Transplant International. 26:22-29
We have recently described the immunosuppressive properties of AR-C117977 and AR-C122982, representatives of a group of compounds identified as inhibitors of lactate transporters (monocarboxylate transporters; MCTs). These compounds demonstrate the p
Autor:
Clara Påhlman, David Donald, Béla Veress, Robert V. Bundick, Helene Malm, Clare Murray, Henrik Ekberg, Zhongquan Qi, Douglas Ferguson
Publikováno v:
Transplantation. 86:1135-1138
AR-C117977, a monocarboxylate transporter inhibitor, reduces immune responses both in vitro and in vivo, maintains long-term graft survival, and induces operational tolerance. To evaluate the immunosuppressive limitations of AR-C117977, this study wa
Autor:
Brian Choo-Kang, James M. Brewer, Robert V. Bundick, Iain B. McInnes, Andrew J. Leishman, Paul Garside, S. Hutchison
Publikováno v:
Clinical and Experimental Immunology. 151:114-122
Summary Asthma is a heterogeneous disease that has been increasing in incidence throughout western societies and cytokines, including proinflammatory tumour necrosis factor alpha (TNF-α), have been implicated in the pathogenesis of asthma. Anti-TNF-
Autor:
Graham Belfield, Perry Matthew, John R. Bantick, David J. Wilkinson, Diana Brazma, Paul Rugman, Robert V. Bundick, David A. Taylor-Fishwick, Clive G. Jackson, Amanda D Benjamin, Robert I. Craggs, P Craig Walker, David Donald, Andrew Wright, Susan Edwards, Raymond Hutchinson, Leslie Evans, I David Cook, Yvonne M Whitehead, Michael Sullivan, Sasvinder S Sidhu, Andrew R J Ross, Andrew P. Jackson, Lee P. Kingston, Richard P. Harrison, Elain Holness, Clare Murray
Publikováno v:
Scopus-Elsevier
Current immunosuppressive therapies act on T lymphocytes by modulation of cytokine production, modulation of signaling pathways or by inhibition of the enzymes of nucleotide biosynthesis. We have identified a previously unknown series of immunomodula
Autor:
Clara, Påhlman, Zhongquan, Qi, Clare M, Murray, Douglas, Ferguson, Robert V, Bundick, David K, Donald, Henrik, Ekberg
Publikováno v:
Transplant international : official journal of the European Society for Organ Transplantation. 26(1)
We have recently described the immunosuppressive properties of AR-C117977 and AR-C122982, representatives of a group of compounds identified as inhibitors of lactate transporters (monocarboxylate transporters; MCTs). These compounds demonstrate the p
Autor:
Paola Conigliaro, Andrew J. Leishman, Paul Garside, Guido Valesini, Robert V. Bundick, James M. Brewer, M. B. Nickdel, Iain B. McInnes, Robert A. Benson, S. Hutchison
Background: The relative roles of innate immunity and antigen-specific T cells in rheumatoid arthritis remain controversial. Previous studies demonstrated that T-helper type 1 cells of irrelevant antigen specificity (ovalbumin) induced a transient ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92dbdecc1bf411cf8cf055553101afb2
http://hdl.handle.net/11573/87671
http://hdl.handle.net/11573/87671
Autor:
Andrew J. Leishman, Paul Garside, S. Hutchison, Robert V. Bundick, Iain B. McInnes, Vivienne B. Gibson, Brian Choo-Kang, James M. Brewer
Publikováno v:
Clinical and experimental immunology. 155(1)
SummaryIt is widely accepted that allergic asthma is orchestrated by T helper type 2 lymphocytes specific for inhaled allergen. However, it remains unclear where and when T cell activation and division occurs after allergen challenge, and whether the
Autor:
Robert V. Bundick, Isabelle Binet, David Donald, Valquiria Bueno, Ulrich Steger, Clare Murray, Kathryn J. Wood, Douglas Ferguson
Publikováno v:
Transplantation. 84(9)
Novel small molecular weight compounds that act by inhibiting the monocarboxylate transporter (MCT1) receptor have been found to cause profound inhibition of T-cell responses to alloantigen in vitro. Here, we have investigated the ability of one comp
Autor:
Mohammad B. Nickdel, James M. Brewer, Robert V. Bundick, Sharon Hutchison, Iain B. McInnes, Andrew J. Leishman, Paul Garside, Brian Choo-Kang
Publikováno v:
Trends in immunology. 26(10)
Despite expanding use of drugs blocking tumour necrosis factor (TNF), their precise mechanisms of action remain unclear. Early assumptions that they act by direct neutralization of the toxic inflammatory effects of TNF might be too simplistic because