Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Robert V. Brown"'
Autor:
K. Saidas Nair, Chitrangda Srivastava, Robert V. Brown, Swanand Koli, Hélène Choquet, Hong Soon Kang, Yien-Ming Kuo, Sara A. Grimm, Caleb Sutherland, Alexandra Badea, G. Allan Johnson, Yin Zhao, Jie Yin, Kyoko Okamoto, Graham Clark, Terete Borrás, Gulab Zode, Krishnakumar Kizhatil, Subhabrata Chakrabarti, Simon W. M. John, Eric Jorgenson, Anton M. Jetten
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Dysfunction of the trabecular meshwork (TM) is the chief cause of elevated intraocular pressure, the major risk factor of glaucoma. Here, the authors identify the transcription factor, GLIS1, as a critical regulator of TM maintenance and intraocular
Externí odkaz:
https://doaj.org/article/1d13ccf102314720a834e165f6b1a62d
Publikováno v:
Molecules, Vol 18, Iss 12, Pp 15019-15034 (2013)
ADAM-15, with known zymogen, secretase, and disintegrin activities, is a catalytically active member of the ADAM family normally expressed in early embryonic development and aberrantly expressed in various cancers, including breast, prostate and lung
Externí odkaz:
https://doaj.org/article/ae5ea5ae43e14ad69b5d7d727df54ede
Autor:
Cassandra L. Gorsuch, Paige Nemec, Mei Yu, Simin Xu, Dong Han, Jeff Smith, Janel Lape, Nicholas van Buuren, Ricardo Ramirez, Robert C. Muench, Meghan M. Holdorf, Becket Feierbach, Greg Falls, Jason Holt, Wendy Shoop, Emma Sevigny, Forrest Karriker, Robert V. Brown, Amod Joshi, Tyler Goodwin, Ying K. Tam, Paulo J.C. Lin, Sean C. Semple, Neil Leatherbury, William E. Delaney IV, Derek Jantz, Amy Rhoden Smith
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 30(9)
Persistence of chronic hepatitis B (CHB) is attributed to maintenance of the intrahepatic pool of the viral covalently closed circular DNA (cccDNA), which serves as the transcriptional template for all viral gene products required for replication. Cu
Autor:
Eddie T. Chiang, Venkateshwar Reddy Chappeta, Megan A. Turnidge, Reena Chawla, Danzhou Yang, Quinea R. Lassiter, Carmen Lee, Hector Quijada, Robert V. Brown, Shivani Phanse, Ping Zhao, Joe G.N. Garcia, Ting Wang, Laurence H. Hurley, Buket Onel, Sara M. Camp, Guanhui Wu, Vijay Gokhale
Publikováno v:
Journal of the American Chemical Society. 139:7456-7475
The platelet-derived growth factor receptor β (PDGFR-β) signaling pathway is a validated and important target for the treatment of certain malignant and nonmalignant pathologies. We previously identified a G-quadruplex-forming nuclease hypersensiti
Autor:
Ramesh C. Kovi, Yu Wang, Caleb Sutherland, Anton M. Jetten, Beth W. Mahler, Kyathanahalli S. Janardhan, Julie F. Foley, Robert V. Brown
Publikováno v:
Journal of visualized experiments : JoVE. (136)
Laser capture microdissection (LCM) has allowed gene expression analysis of single cells and enriched cell populations in tissue sections. LCM is a great tool for the study of the molecular mechanisms underlying cell differentiation and the developme
Publikováno v:
Cancer Research. 75:P2-06
Breast cancer stem cells are contribute to distance metastasis, breast cancer recurrence and drug resistance. SIRT1, a nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylase, play significant role in DNA repair, cell survival, stem ce
Autor:
Laurence H. Hurley, Yuwei Chen, Danzhou Yang, Prashansa Agrawal, Robert V. Brown, Emmanuel Hatzakis
Publikováno v:
Journal of the American Chemical Society. 134:13220-13223
Overexpression of platelet-derived growth factor receptor β (PDGFR-β) has been associated with cancers and vascular and fibrotic disorders. PDGFR-β has become an attractive target for the treatment of cancers and fibrotic disorders. DNA G-quadrupl
Autor:
Robert V. Brown, Laurence H. Hurley
Publikováno v:
Biochemical Society Transactions. 39:635-640
Over the last decade or so, secondary non-B-DNA structures such as G-quadruplexes and i-motifs have come into focus as biologically functioning moieties that are potentially involved in telomeric interactions and the control of gene expression. In th
Autor:
MinJin Kang, Robert V. Brown, Ya Ming Xu, E. M. Kithsiri Wijeratne, A. A. Leslie Gunatilaka, Eric C. Lau, Donna D. Zhang, Tongde Wu, Eli Chapman, Joseph Tillotson, Shasha Tao, Celestina Mesa, Damian J. Mason, James J. La Clair
Understanding the mode of action (MOA) of many natural products can be puzzling with mechanistic clues that seem to lack a common thread. One such puzzle lies in the evaluation of the antitumor properties of the natural product withaferin A (WFA). A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bdc0291f4856746cf040196970b3149
https://europepmc.org/articles/PMC4593394/
https://europepmc.org/articles/PMC4593394/
Autor:
Robert V. Brown, John B. Frantz
Publikováno v:
Pennsylvania History: A Journal of Mid-Atlantic Studies. 80:299-301