Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Robert V Farese Jr"'
Autor:
Chandramohan Chitraju, Alexander W Fischer, Yohannes A Ambaw, Kun Wang, Bo Yuan, Sheng Hui, Tobias C Walther, Robert V Farese Jr
Publikováno v:
eLife, Vol 12 (2023)
Triglycerides (TGs) in adipocytes provide the major stores of metabolic energy in the body. Optimal amounts of TG stores are desirable as insufficient capacity to store TG, as in lipodystrophy, or exceeding the capacity for storage, as in obesity, re
Externí odkaz:
https://doaj.org/article/ba813d87647e4df984e576443c646267
Autor:
Lauren Herl Martens, Jiasheng Zhang, Sami J. Barmada, Ping Zhou, Sherry Kamiya, Binggui Sun, Sang-Won Min, Li Gan, Steven Finkbeiner, Eric J. Huang, Robert V. Farese Jr
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 1 (2022)
Externí odkaz:
https://doaj.org/article/e1a9c0e0f6b14866a258fab75e500c8f
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 6, Pp 1112-1120 (2019)
Mammals store metabolic energy as triacylglycerols (TGs) in adipose tissue. TG synthesis is catalyzed by the evolutionarily unrelated acyl-CoA:diacylglycerol acyltransferase (DGAT) enzymes DGAT1 and DGAT2, which catalyze the same reaction and account
Externí odkaz:
https://doaj.org/article/5ed27511d9fa4f5fab369ea209608013
Publikováno v:
Cell Reports, Vol 33, Iss 5, Pp 108348- (2020)
Summary: Brown adipocytes store metabolic energy as triglycerides (TGs) in lipid droplets (LDs). Fatty acids released from brown adipocyte LDs by lipolysis are thought to activate and fuel UCP1-mediated thermogenesis. Here, we test this hypothesis by
Externí odkaz:
https://doaj.org/article/0b313c34c0ba4ccdb5f8476de02edd2f
Autor:
Nina L. Gluchowski, Chandramohan Chitraju, Joseph A. Picoraro, Niklas Mejhert, Shirly Pinto, Winnie Xin, Daniel S. Kamin, Harland S. Winter, Wendy K. Chung, Tobias C. Walther, Robert V. Farese, Jr.
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 6, Pp 1230-1237 (2017)
Acyl-CoA:diacylglycerol acyltransferase (DGAT)1 and DGAT2 catalyze triglyceride (TG) biosynthesis in humans. Biallelic loss-of-function mutations in human DGAT1 result in severe congenital diarrhea and protein-losing enteropathy. Additionally, pharma
Externí odkaz:
https://doaj.org/article/677ba14c9319443a9790d97cd1e3b8e7
Autor:
Nora Kory, Susanne Grond, Siddhesh S. Kamat, Zhihuan Li, Natalie Krahmer, Chandramohan Chitraju, Ping Zhou, Florian Fröhlich, Ivana Semova, Christer Ejsing, Rudolf Zechner, Benjamin F. Cravatt, Robert V. Farese, Jr., Tobias C. Walther
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 1, Pp 226-235 (2017)
Variations in the gene LDAH (C2ORF43), which encodes lipid droplet-associated hydrolase (LDAH), are among few loci associated with human prostate cancer. Homologs of LDAH have been identified as proteins of lipid droplets (LDs). LDs are cellular orga
Externí odkaz:
https://doaj.org/article/3ec52a4ce7e4467191376e0d18ab2f9f
Autor:
Erin Currie, Xiuling Guo, Romain Christiano, Chandramohan Chitraju, Nora Kory, Kenneth Harrison, Joel Haas, Tobias C. Walther, Robert V. Farese, Jr.
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 7, Pp 1465-1477 (2014)
Accurate protein inventories are essential for understanding an organelle's functions. The lipid droplet (LD) is a ubiquitous intracellular organelle with major functions in lipid storage and metabolism. LDs differ from other organelles because they
Externí odkaz:
https://doaj.org/article/38e773b11d0b498bb87e2ac1fb8ce5eb
Autor:
Robin W. Klemm, Justin P. Norton, Ronald A. Cole, Chen S. Li, Seong H. Park, Matthew M. Crane, Liying Li, Diana Jin, Alexandra Boye-Doe, Tina Y. Liu, Yoko Shibata, Hang Lu, Tom A. Rapoport, Robert V. Farese, Jr., Craig Blackstone, Yi Guo, Ho Yi Mak
Publikováno v:
Cell Reports, Vol 3, Iss 5, Pp 1465-1475 (2013)
Lipid droplets (LDs) are the major fat storage organelles in eukaryotic cells, but how their size is regulated is unknown. Using genetic screens in C. elegans for LD morphology defects in intestinal cells, we found that mutations in atlastin, a GTPas
Externí odkaz:
https://doaj.org/article/70257a33a26343e89708a3a6891a3693
Autor:
Huajin Wang, Michel Becuwe, Benjamin E Housden, Chandramohan Chitraju, Ashley J Porras, Morven M Graham, Xinran N Liu, Abdou Rachid Thiam, David B Savage, Anil K Agarwal, Abhimanyu Garg, Maria-Jesus Olarte, Qingqing Lin, Florian Fröhlich, Hans Kristian Hannibal-Bach, Srigokul Upadhyayula, Norbert Perrimon, Tomas Kirchhausen, Christer S Ejsing, Tobias C Walther, Robert V Farese Jr
Publikováno v:
eLife, Vol 5 (2016)
How proteins control the biogenesis of cellular lipid droplets (LDs) is poorly understood. Using Drosophila and human cells, we show here that seipin, an ER protein implicated in LD biology, mediates a discrete step in LD formation—the conversion o
Externí odkaz:
https://doaj.org/article/883e847c4c0c4cafacec7a73841c1ae8
Autor:
Sandra Almeida, Zhijun Zhang, Giovanni Coppola, Wenjie Mao, Kensuke Futai, Anna Karydas, Michael D. Geschwind, M. Carmela Tartaglia, Fuying Gao, Davide Gianni, Miguel Sena-Esteves, Daniel H. Geschwind, Bruce L. Miller, Robert V. Farese, Jr., Fen-Biao Gao
Publikováno v:
Cell Reports, Vol 2, Iss 4, Pp 789-798 (2012)
The pathogenic mechanisms of frontotemporal dementia (FTD) remain poorly understood. Here we generated multiple induced pluripotent stem cell lines from a control subject, a patient with sporadic FTD, and an FTD patient with a novel heterozygous GRN
Externí odkaz:
https://doaj.org/article/2adf8552b17e40d2a9317f84afa9d11e