Zobrazeno 1 - 10
of 469
pro vyhledávání: '"Robert V Farese"'
Autor:
Chandramohan Chitraju, Alexander W Fischer, Yohannes A Ambaw, Kun Wang, Bo Yuan, Sheng Hui, Tobias C Walther, Robert V Farese Jr
Publikováno v:
eLife, Vol 12 (2023)
Triglycerides (TGs) in adipocytes provide the major stores of metabolic energy in the body. Optimal amounts of TG stores are desirable as insufficient capacity to store TG, as in lipodystrophy, or exceeding the capacity for storage, as in obesity, re
Externí odkaz:
https://doaj.org/article/ba813d87647e4df984e576443c646267
Autor:
Siyoung Kim, Jeeyun Chung, Henning Arlt, Alexander J Pak, Robert V Farese Jnr, Tobias C Walther, Gregory A Voth
Publikováno v:
eLife, Vol 11 (2022)
Lipid droplets (LDs) are organelles formed in the endoplasmic reticulum (ER) to store triacylglycerol (TG) and sterol esters. The ER protein seipin is key for LD biogenesis. Seipin forms a cage-like structure, with each seipin monomer containing a co
Externí odkaz:
https://doaj.org/article/45901e8cb1ba41fd93941bb6a40f02e9
Autor:
Huajin Wang, Michel Becuwe, Benjamin E Housden, Chandramohan Chitraju, Ashley J Porras, Morven M Graham, Xinran N Liu, Abdou Rachid Thiam, David B Savage, Anil K Agarwal, Abhimanyu Garg, Maria-Jesus Olarte, Qingqing Lin, Florian Fröhlich, Hans Kristian Hannibal-Bach, Srigokul Upadhyayula, Norbert Perrimon, Tomas Kirchhausen, Christer S Ejsing, Tobias C Walther, Robert V Farese Jr
Publikováno v:
eLife, Vol 5 (2016)
How proteins control the biogenesis of cellular lipid droplets (LDs) is poorly understood. Using Drosophila and human cells, we show here that seipin, an ER protein implicated in LD biology, mediates a discrete step in LD formation—the conversion o
Externí odkaz:
https://doaj.org/article/883e847c4c0c4cafacec7a73841c1ae8
Autor:
Panayiotis Tsokas, Changchi Hsieh, Yudong Yao, Edith Lesburguères, Emma Jane Claire Wallace, Andrew Tcherepanov, Desingarao Jothianandan, Benjamin Rush Hartley, Ling Pan, Bruno Rivard, Robert V Farese, Mini P Sajan, Peter John Bergold, Alejandro Iván Hernández, James E Cottrell, Harel Z Shouval, André Antonio Fenton, Todd Charlton Sacktor
Publikováno v:
eLife, Vol 5 (2016)
PKMζ is a persistently active PKC isoform proposed to maintain late-LTP and long-term memory. But late-LTP and memory are maintained without PKMζ in PKMζ-null mice. Two hypotheses can account for these findings. First, PKMζ is unimportant for LTP
Externí odkaz:
https://doaj.org/article/10b79fb456d444189cf41efe0ed46ed9
Autor:
Florian Fröhlich, Constance Petit, Nora Kory, Romain Christiano, Hans-Kristian Hannibal-Bach, Morven Graham, Xinran Liu, Christer S Ejsing, Robert V Farese Jr, Tobias C Walther
Publikováno v:
eLife, Vol 4 (2015)
Sphingolipids are abundant membrane components and important signaling molecules in eukaryotic cells. Their levels and localization are tightly regulated. However, the mechanisms underlying this regulation remain largely unknown. In this study, we id
Externí odkaz:
https://doaj.org/article/0230e65b8c7b4312b88ff014183e4da8
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132575 (2015)
AimsTo evaluate whether pharmacological TLR4 inhibition protects against acute and chronic fat-induced insulin resistance in rats.Materials and methodsFor the acute experiment, rats received a TLR4 inhibitor [TAK-242 or E5564 (2x5 mg/kg i.v. bolus)]
Externí odkaz:
https://doaj.org/article/7adf5d5e0f8c4e26b2ef79bf784a1127
Autor:
Florian Wilfling, Abdou Rachid Thiam, Maria-Jesus Olarte, Jing Wang, Rainer Beck, Travis J Gould, Edward S Allgeyer, Frederic Pincet, Jörg Bewersdorf, Robert V Farese Jr, Tobias C Walther
Publikováno v:
eLife, Vol 3 (2014)
Lipid droplets (LDs) are ubiquitous organelles that store neutral lipids, such as triacylglycerol (TG), as reservoirs of metabolic energy and membrane precursors. The Arf1/COPI protein machinery, known for its role in vesicle trafficking, regulates L
Externí odkaz:
https://doaj.org/article/3f17b81e1d274a1697271fc083c51a8f
Autor:
Zhijun Zhang, Sandra Almeida, Yubing Lu, Agnes L Nishimura, Lingtao Peng, Danqiong Sun, Bei Wu, Anna M Karydas, Maria C Tartaglia, Jamie C Fong, Bruce L Miller, Robert V Farese, Melissa J Moore, Christopher E Shaw, Fen-Biao Gao
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76055 (2013)
Transactive response DNA-binding protein 43 (TDP-43) is a major pathological protein in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). There are many disease-associated mutations in TDP-43, and several cellular and animal mode
Externí odkaz:
https://doaj.org/article/5de32ce1e9eb475886970e31912f27e2
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10551 (2010)
Progranulin deficiency is thought to cause some forms of frontotemporal dementia (FTD), a major early-onset age-dependent neurodegenerative disease. How progranulin (PGRN) expression is regulated is largely unknown. We identified an evolutionarily co
Externí odkaz:
https://doaj.org/article/fbcf4fbb603a49799d670093324f2056
Autor:
Xuewu Sui, Kun Wang, Kangkang Song, Chen Xu, Jiunn Song, Chia-Wei Lee, Maofu Liao, Robert V. Farese, Tobias C. Walther
Publikováno v:
Nature Communications. 14
Inhibitors of triacylglycerol (TG) synthesis have been developed to treat metabolism-related diseases, but we know little about their mechanisms of action. Here, we report cryo-EM structures of the TG-synthesis enzyme acyl-CoA:diacylglycerol acyltran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d87d0c1f13184b9de074cbedbe974e88
https://doi.org/10.1038/s41467-023-38934-3
https://doi.org/10.1038/s41467-023-38934-3