Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Robert Tonge"'
Autor:
Dale A. Cooper-Shepherd, Jason Wildgoose, Boris Kozlov, William J. Johnson, Richard Tyldesley-Worster, Martin E. Palmer, John B. Hoyes, Michael McCullagh, Emrys Jones, Robert Tonge, Emma Marsden-Edwards, Peter Nixon, Anatoly Verenchikov, James I. Langridge
Publikováno v:
Journal of the American Society for Mass Spectrometry.
A novel mass spectrometry system is described here comprising a quadrupole-multireflecting time-of-flight design. The new multireflecting time-of-flight analyzer has an effective path length of 48 m and employs planar, gridless ion mirrors providing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5930d984a7b19fb5e86f27b0b63fd99d
https://pubmed.ncbi.nlm.nih.gov/36603847
https://pubmed.ncbi.nlm.nih.gov/36603847
Autor:
Emmanuelle Claude, James I. Langridge, Reza Mirnezami, Dieter Galea, Jonathan P. Sleeman, Zoltan Takats, Ivan Laponogov, Robert Tonge, Kirill Veselkov, Mark W. Towers, Jeremy K. Nicholson, Anna Mroz, Johannes P. C. Vissers
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific reports, 8 (1), Art.Nr.: 4053
Scientific Reports
Scientific reports, 8 (1), Art.Nr.: 4053
Scientific Reports
Mass Spectrometry Imaging (MSI) holds significant promise in augmenting digital histopathologic analysis by generating highly robust big data about the metabolic, lipidomic and proteomic molecular content of the samples. In the process, a vast quanti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::100446417b631c58ba357b4bad326c98
http://link.springer.com/article/10.1038/s41598-018-22499-z
http://link.springer.com/article/10.1038/s41598-018-22499-z
Autor:
Vassilis Aggelis, Rosamonde E. Banks, Robert Tonge, Jianhe Peng, Gilberto E. Hernandez, Rachel A. Craven, Patricia Harnden, Steven R. Head, Peter Selby, Eamonn R. Maher, Lana Schaffer
Publikováno v:
International Journal of Oncology
Identification of novel biomarkers and targets in renal cell carcinoma (RCC) remains a priority and one cellular compartment that is a rich potential source of such molecules is the plasma membrane. A shotgun proteomic analysis of cell surface protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f76456745fee689bffbc9051dc63855f
http://europepmc.org/articles/PMC3823392
http://europepmc.org/articles/PMC3823392
Autor:
David Jackson, Andrew Hughes, Kevin Cheeseman, Jonathan Swinton, Robert Tonge, David Bramwell, Athula Herath, Rajesh Chopra
Publikováno v:
PROTEOMICS - CLINICAL APPLICATIONS. 3:394-407
Proteomics is increasingly being applied to the human plasma proteome to identify biomarkers of disease for use in non-invasive assays. 2-D DIGE, simultaneously analysing thousands of protein spots quantitatively and maintaining protein isoform infor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adff90b7439255eac8a726d12ecb13d8
https://doi.org/10.1002/prca.200800066
https://doi.org/10.1002/prca.200800066
Autor:
Guenter Daxenbichler, Rachel A. Craven, Geoffrey Hall, Michael Hubalek, Steve Rayner, Richard Hutson, David Jackson, Benjamin Dieplinger, Rosamonde E. Banks, Janice Nickson, Nafisa Wilkinson, Joanne L. Hartley, Paul Lueth, Timothy J. Perren, Colin Johnston, Hans Dieplinger, Ina Graze, Robert Tonge, Peter Selby, Sean Kehoe
Publikováno v:
Clinical Cancer Research. 13:7370-7379
Purpose: To discover and validate serum glycoprotein biomarkers in ovarian cancer using proteomic-based approaches. Experimental Design: Serum samples from a “discovery set” of 20 patients with ovarian cancer or benign ovarian cysts or healthy vo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baa51898abe8d846a259589eff8aa214
https://doi.org/10.1158/1078-0432.ccr-07-0747
https://doi.org/10.1158/1078-0432.ccr-07-0747
Autor:
Jonathan D. Mills, Mattias Rantalainen, Olaf Beckonert, Rachel Rowlinson, Ian D. Wilson, Steve Rayner, Olivier Cloarec, Robert Tonge, Johan Trygg, David A. Jackson, Robert W. Wilkinson, Elaine Holmes, Janice Nickson, Jeremy K. Nicholson
Publikováno v:
Journal of Proteome Research. 5:2642-2655
A novel statistically integrated proteometabonomic method has been developed and applied to a human tumor xenograft mouse model of prostate cancer. Parallel 2D-DIGE proteomic and 1H NMR metabolic profile data were collected on blood plasma from mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98709c9b741717aea9512775b7af744e
https://doi.org/10.1021/pr060124w
https://doi.org/10.1021/pr060124w
Autor:
Ian D. Wilson, Rachel Rowlinson, Janice Nickson, Cassie K. Eaton, David Jackson, Robert W. Wilkinson, Robert Tonge, Jonathan D. Mills
Publikováno v:
PROTEOMICS. 6:3901-3908
Clinical studies often produce fresh tissue samples, which ideally should be immediately snap frozen for storage and subsequent analysis. However, this is often not practically possible, and there is inevitably a time period during which the sample i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc1a46b3b725502f7a2c49a400875f2e
https://doi.org/10.1002/pmic.200500794
https://doi.org/10.1002/pmic.200500794
Autor:
Rachel Rowlinson, Andrew Craig, Robert Tonge, David A. Jackson, Ian D. Wilson, James E. Sidaway, Janice Nickson, Jeremy K. Nicholson, Terry C. Orton, Elaine Holmes
Publikováno v:
Journal of Proteome Research. 5:1586-1601
Administration of high doses of the histamine antagonist methapyrilene to rats causes periportal liver necrosis. The mechanism of toxicity is ill-defined and here we have utilized an integrated systems approach to understanding the toxic mechanisms b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::821030ea8ec8907a9afaf80f853b8a31
https://doi.org/10.1021/pr0503376
https://doi.org/10.1021/pr0503376
Publikováno v:
PROTEOMICS. 5:2315-2318
There is an increasing interest in analysing the human urinary proteome in the search for biomarkers. However, despite the ease of its collection, urine is a difficult fluid to analyse by two-dimensional polyacrylamide gel electrophoresis (2-D PAGE)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6133a5c4e64c69d78d3a5e7ff5da54db
https://doi.org/10.1002/pmic.200401267
https://doi.org/10.1002/pmic.200401267
Autor:
Andrew Pierce, Anthony D. Whetton, Elaine Spooncer, C. Peter Downes, Simon J. Gaskell, Alexander Gray, Caroline A. Evans, Robert Tonge, Yuning Lu, David Blinco, Hajja G. Hamzah, Joanne Shaw
Publikováno v:
Blood. 103:3751-3759
Lineage-marker depleted (Lin(-)) murine bone marrow cells expressing stem cell antigen 1 (Sca-1) were sorted on the basis of stem cell factor receptor (c-kit) expression to obtain Lin(-)Sca(+)Kit(+) or Lin(-)Sca(+)Kit(-) cells. Lin(-)Sca(+)Kit(-) cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2993bbf08de9577a36505df3a51a18c5
https://doi.org/10.1182/blood-2003-09-3294
https://doi.org/10.1182/blood-2003-09-3294