Zobrazeno 1 - 10
of 552
pro vyhledávání: '"Robert Tibshirani"'
Autor:
Ahmet Gorkem Er, Daisy Yi Ding, Berrin Er, Mertcan Uzun, Mehmet Cakmak, Christoph Sadee, Gamze Durhan, Mustafa Nasuh Ozmen, Mine Durusu Tanriover, Arzu Topeli, Yesim Aydin Son, Robert Tibshirani, Serhat Unal, Olivier Gevaert
Publikováno v:
npj Digital Medicine, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Through technological innovations, patient cohorts can be examined from multiple views with high-dimensional, multiscale biomedical data to classify clinical phenotypes and predict outcomes. Here, we aim to present our approach for analyzing
Externí odkaz:
https://doaj.org/article/60405c4434f3445781f9660de29169a1
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract The COVID-19 pandemic has taken a devastating toll around the world. Since January 2020, the World Health Organization estimates 14.9 million excess deaths have occurred globally. Despite this grim number quantifying the deadly impact, the u
Externí odkaz:
https://doaj.org/article/e0fb74b82f004b598feb4f945e7b817f
Autor:
Abhinav Kaushik, Diane Dunham, Xiaorui Han, Evan Do, Sandra Andorf, Sheena Gupta, Andrea Fernandes, Laurie Elizabeth Kost, Sayantani B. Sindher, Wong Yu, Mindy Tsai, Robert Tibshirani, Scott D. Boyd, Manisha Desai, Holden T. Maecker, Stephen J. Galli, R. Sharon Chinthrajah, Rosemarie H. DeKruyff, Monali Manohar, Kari C. Nadeau
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Oral immunotherapy (OIT) clinical trials have helped a subset of participants achieve sustained unresponsiveness (SU) to the cognate allergen. Here the authors analyse immune cells from participants from one peanut OIT trial and show that CD8+ T cell
Externí odkaz:
https://doaj.org/article/f3d3643e782c428e859a1f49273bc85c
Autor:
Vishnu Shankar, Basil Michael, Alessandra Celli, Zhenpeng Zhou, Melanie D. Ashland, Robert Tibshirani, Michael Snyder, Richard N. Zare
Publikováno v:
Natural Sciences, Vol 3, Iss 2, Pp n/a-n/a (2023)
Abstract End‐stage renal disease (ESRD), characterized by cessation in kidney function, has been linked to severe metabolic disturbances, caused by the buildup of toxic solutes in blood. To remove these solutes, ESRD patients undergo dialysis. As a
Externí odkaz:
https://doaj.org/article/54c73f624acc4f2b9f9eda3b3a82700f
Autor:
Yosuke Tanigawa, Junyang Qian, Guhan Venkataraman, Johanne Marie Justesen, Ruilin Li, Robert Tibshirani, Trevor Hastie, Manuel A Rivas
Publikováno v:
PLoS Genetics, Vol 18, Iss 3, p e1010105 (2022)
We present a systematic assessment of polygenic risk score (PRS) prediction across more than 1,500 traits using genetic and phenotype data in the UK Biobank. We report 813 sparse PRS models with significant (p < 2.5 x 10-5) incremental predictive per
Externí odkaz:
https://doaj.org/article/40b16052b1c54592a901ecc6fce1d7d0
Autor:
Loukia G. Karacosta, Benedict Anchang, Nikolaos Ignatiadis, Samuel C. Kimmey, Jalen A. Benson, Joseph B. Shrager, Robert Tibshirani, Sean C. Bendall, Sylvia K. Plevritis
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Intermediate transitions between epithelial and mesenchymal states are associated with tumor progression. Here using mass cytometry, Plevritis and colleagues develop a computational framework to resolve and map these trajectories in lung cancer cells
Externí odkaz:
https://doaj.org/article/32513de8c44b402d8bbb56fe5705714c
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 6, p e1009119 (2021)
Cancer is the result of mutagenic processes that can be inferred from tumor genomes by analyzing rate spectra of point mutations, or "mutational signatures". Here we present SparseSignatures, a novel framework to extract signatures from somatic point
Externí odkaz:
https://doaj.org/article/ed06227f6ba944be9baaed2c108694e4
Autor:
Junyang Qian, Yosuke Tanigawa, Wenfei Du, Matthew Aguirre, Chris Chang, Robert Tibshirani, Manuel A Rivas, Trevor Hastie
Publikováno v:
PLoS Genetics, Vol 16, Iss 10, p e1009141 (2020)
The UK Biobank is a very large, prospective population-based cohort study across the United Kingdom. It provides unprecedented opportunities for researchers to investigate the relationship between genotypic information and phenotypes of interest. Mul
Externí odkaz:
https://doaj.org/article/8bf4e306fba240a4ae64c033052847fc
Autor:
Livia S Eberlin, Katherine Margulis, Ivette Planell-Mendez, Richard N Zare, Robert Tibshirani, Teri A Longacre, Moe Jalali, Jeffrey A Norton, George A Poultsides
Publikováno v:
PLoS Medicine, Vol 13, Iss 8, p e1002108 (2016)
BACKGROUND:Surgical resection with microscopically negative margins remains the main curative option for pancreatic cancer; however, in practice intraoperative delineation of resection margins is challenging. Ambient mass spectrometry imaging has eme
Externí odkaz:
https://doaj.org/article/eb971e4c2cf945cba3318ffb66da574e
Autor:
Murali D. Bashyam, Ryan Bair, Young H. Kim, Pei Wang, Tina Hernandez-Boussard, Collins A. Karikari, Robert Tibshirani, Anirban Maitra, Jonathan R. Pollack
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 7, Iss 6, Pp 556-562 (2005)
Pancreatic cancer, the fourth leading cause of cancer death in the United States, is frequently associated with the amplification and deletion of specific oncogenes and tumor-suppressor genes (TSGs), respectively. To identify such novel alterations a
Externí odkaz:
https://doaj.org/article/a08843602edd4c5996e68b59a7bdd279