Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Robert Thänert"'
Publikováno v:
Microbiome, Vol 10, Iss 1, Pp 1-13 (2022)
Abstract Background The lack of a definition of urinary microbiome health convolutes diagnosis of urinary tract infections (UTIs), especially when non-traditional uropathogens or paucity of bacteria are recovered from symptomatic patients in routine
Externí odkaz:
https://doaj.org/article/541d7838b0514e688c16b798ea42063b
Autor:
Robert Thänert, Andreas Itzek, Jörn Hoßmann, Domenica Hamisch, Martin Bruun Madsen, Ole Hyldegaard, Steinar Skrede, Trond Bruun, Anna Norrby-Teglund, INFECT study group, Eva Medina, Dietmar H. Pieper
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Necrotizing soft tissue infections (NSTIs) are caused by a single pathogen such as Streptococcus pyogenes or by multiple bacterial species. Here, the authors integrate microbial community profiling with host and pathogen transcriptional analysis in p
Externí odkaz:
https://doaj.org/article/a71db1a3f33741e88b0fff82cb740d6b
Autor:
Robert Thänert, Anna Thänert, Jocelyn Ou, Adam Bajinting, Carey-Ann D. Burnham, Holly J. Engelstad, Maria E. Tecos, I. Malick Ndao, Carla Hall-Moore, Colleen Rouggly-Nickless, Mike A. Carl, Deborah C. Rubin, Nicholas O. Davidson, Phillip I. Tarr, Barbara B. Warner, Gautam Dantas, Brad W. Warner
Publikováno v:
Gut Microbes, Vol 13, Iss 1 (2021)
Surgical removal of the intestine, lifesaving in catastrophic gastrointestinal disorders of infancy, can result in a form of intestinal failure known as short bowel syndrome (SBS). Bloodstream infections (BSIs) are a major challenge in pediatric SBS
Externí odkaz:
https://doaj.org/article/34e2a30a876a42fbb17b0150d61db8e2
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Drugs inhibiting virulence factors of bacterial pathogens are under development. Here, Thänertet al. analyse the transcriptomes of host and pathogen during Staphylococcus aureusinfection of two mouse strains, and show that virulence determinants are
Externí odkaz:
https://doaj.org/article/5e49170ea1ff42948166598323b9bb35
Autor:
Robert Thänert, Kimberly A. Reske, Tiffany Hink, Meghan A. Wallace, Bin Wang, Drew J. Schwartz, Sondra Seiler, Candice Cass, Carey-Ann D. Burnham, Erik R. Dubberke, Jennie H. Kwon, Gautam Dantas
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
ABSTRACT The rise of antimicrobial resistance in uropathogens has complicated the management of urinary tract infections (UTIs), particularly in patients who are afflicted by recurrent episodes of UTIs. Antimicrobial-resistant (AR) uropathogens persi
Externí odkaz:
https://doaj.org/article/178973ce923046828ec7dffd4b293478
Publikováno v:
J Infect Dis
Decades of research have failed to define the pathophysiology of necrotizing enterocolitis (NEC), a devastating pediatric gastrointestinal disorder of preterm infants. However, evidence suggests that host-microbiota interactions, in which microbial d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f86a979b51fafe4ee7e6381d6d73a49
https://doi.org/10.1093/infdis/jiaa604
https://doi.org/10.1093/infdis/jiaa604
The resistance within: Antibiotic disruption of the gut microbiome and resistome dynamics in infancy
Publikováno v:
Cell Host Microbe
Intestinal host-microbiota interactions during the first year of life are critical for infant development. Early-life antibiotic exposures disrupt stereotypical gut microbiota maturation and adversely affect childhood health. Furthermore, antibiotics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aa8a24b2500c25c17774d035afafe03
https://pubmed.ncbi.nlm.nih.gov/35550670
https://pubmed.ncbi.nlm.nih.gov/35550670
Autor:
Carla Hall-Moore, Maria E. Tecos, I. Malick Ndao, Brad W. Warner, Anna Thänert, Colleen Rouggly-Nickless, Holly J. Engelstad, Mike A. Carl, Robert Thänert, Jocelyn Ou, Adam Bajinting, Barbara B. Warner, Phillip I. Tarr, Gautam Dantas, Nicholas O. Davidson, Deborah C. Rubin, Carey-Ann D. Burnham
Publikováno v:
Gut Microbes
article-version (VoR) Version of Record
Gut Microbes, Vol 13, Iss 1 (2021)
article-version (VoR) Version of Record
Gut Microbes, Vol 13, Iss 1 (2021)
Surgical removal of the intestine, lifesaving in catastrophic gastrointestinal disorders of infancy, can result in a form of intestinal failure known as short bowel syndrome (SBS). Bloodstream infections (BSIs) are a major challenge in pediatric SBS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d556fa9439d24653705be1ca71fbddb6
http://europepmc.org/articles/PMC8284144
http://europepmc.org/articles/PMC8284144
Autor:
Robert Thänert, JooHee Choi, Kimberly A. Reske, Tiffany Hink, Anna Thänert, Meghan A. Wallace, Bin Wang, Sondra Seiler, Candice Cass, Margaret H. Bost, Emily L. Struttmann, Zainab Hassan Iqbal, Steven R. Sax, Victoria J. Fraser, Arthur W. Baker, Katherine R. Foy, Brett Williams, Ben Xu, Pam Capocci-Tolomeo, Ebbing Lautenbach, Carey-Ann D. Burnham, Erik R. Dubberke, Jennie H. Kwon, Gautam Dantas
Publikováno v:
Cell Host & Microbe. 30:1034-1047.e6
Large-scale genomic studies have identified within-host adaptation as a hallmark of bacterial infections. However, the impact of physiological, metabolic, and immunological differences between distinct niches on the pathoadaptation of opportunistic p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b4abbfb190f113c09e3eebf8c9a7600
https://doi.org/10.1016/j.chom.2022.04.008
https://doi.org/10.1016/j.chom.2022.04.008
Autor:
Stephan A. Sieber, Martin Neuenschwander, Christian Fetzer, Robert Thänert, Jens Peter von Kries, Eva Medina, Kyu Myung Lee, Vadim S. Korotkov
Publikováno v:
Angewandte Chemie. 129:15952-15957
Die ClpXP-Protease von Staphylococcus aureus ist ein wichtiger Regulator der Zellhomoostase und Virulenz. Mithilfe eines Hochdurchsatz-Screenings gegen den ClpXP-Komplex wurde ein spezifischer Inhibitor des ClpX-Chaperons identifiziert, der den oligo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00bf335ee6a617ec6d9b755dcbcc28b8
https://doi.org/10.1002/ange.201708454
https://doi.org/10.1002/ange.201708454