Zobrazeno 1 - 10
of 373
pro vyhledávání: '"Robert Tampé"'
Autor:
Rong Zhu, Daniel Canena, Mateusz Sikora, Miriam Klausberger, Hannah Seferovic, Ahmad Reza Mehdipour, Lisa Hain, Elisabeth Laurent, Vanessa Monteil, Gerald Wirnsberger, Ralph Wieneke, Robert Tampé, Nikolaus F. Kienzl, Lukas Mach, Ali Mirazimi, Yoo Jin Oh, Josef M. Penninger, Gerhard Hummer, Peter Hinterdorfer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Combining high-speed AFM, single molecule recognition force spectroscopy, and molecular dynamics simulations Zhu, Canena, Sikora et al. characterize the interaction dynamics of the trimeric spike protein of SARS-CoV-2 wt, and delta and omicron varian
Externí odkaz:
https://doaj.org/article/4f03cce8155a4e8b9132fcede13abbbb
Autor:
Ines Katharina Müller, Christian Winter, Christoph Thomas, Robbert M. Spaapen, Simon Trowitzsch, Robert Tampé
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Adaptive immunity depends on cellular chaperone and quality control systems that are decisive for an effective presentation of foreign antigens via MHC I molecules. Here, the authors present the structure of a key chaperone-MHC I complex.
Externí odkaz:
https://doaj.org/article/ed4fa68353784c75a71c3a6b5e6374a0
Autor:
Lina Sagert, Christian Winter, Ina Ruppert, Maximilian Zehetmaier, Christoph Thomas, Robert Tampé
Publikováno v:
eLife, Vol 12 (2023)
Adaptive immune responses are triggered by antigenic peptides presented on major histocompatibility complex class I (MHC I) at the surface of pathogen-infected or cancerous cells. Formation of stable peptide-MHC I complexes is facilitated by tapasin
Externí odkaz:
https://doaj.org/article/4afe7db9f697492296b426c4fb3a9539
Autor:
Alexander Domnick, Christian Winter, Lukas Sušac, Leon Hennecke, Mario Hensen, Nicole Zitzmann, Simon Trowitzsch, Christoph Thomas, Robert Tampé
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
The immune system monitors the health status of cells by surveilling fragments of foreign molecules from invaders presented on MHC I complexes at the cell surface. Here, the authors investigate the sequence of events of MHC I assembly and quality con
Externí odkaz:
https://doaj.org/article/269dfaffa8884380b1cc6b3634743425
Publikováno v:
Communications Materials, Vol 3, Iss 1, Pp 1-12 (2022)
Proteins can be patterned in photoresponsive hydrogels by the application of light. Here, a two-photon lithography-based approach allows for the 3D patterning of proteins with micrometer precision, demonstrated for a photoinstructive hydrogel and rel
Externí odkaz:
https://doaj.org/article/b97a0a4e0baa4cf38ea8212bbdd941ea
Autor:
Sunesh Sethumadhavan, Marie Barth, Robbert M. Spaapen, Carla Schmidt, Simon Trowitzsch, Robert Tampé
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Major histocompatibility complex class I (MHC I) molecules present antigenic peptides to cytotoxic T cells to eliminate infected or cancerous cells. The transporter associated with antigen processing (TAP) shuttles proteasomally generated pe
Externí odkaz:
https://doaj.org/article/77e15f94f30b422998f62d3b935e8780
Autor:
Jamina Brunnberg, Valentina Herbring, Esteban Günther Castillo, Heike Krüger, Ralph Wieneke, Robert Tampé
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Brunnberg et al. establish a protocol that enables them to optically control translocation of the transporter associated with antigen processing (TAP), which plays a role in delivering proteasomal degradation products into the ER lumen. Their versati
Externí odkaz:
https://doaj.org/article/7d742d0a34ce4d60b7958af938b31d53
Autor:
Rong Zhu, Daniel Canena, Mateusz Sikora, Miriam Klausberger, Hannah Seferovic, Ahmad Reza Mehdipour, Lisa Hain, Elisabeth Laurent, Vanessa Monteil, Gerald Wirnsberger, Ralph Wieneke, Robert Tampé, Nikolaus F. Kienzl, Lukas Mach, Ali Mirazimi, Yoo Jin Oh, Josef M. Penninger, Gerhard Hummer, Peter Hinterdorfer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/c26dfffaabb146829cede0f13bbf01ee
Autor:
Tim Diederichs, Robert Tampé
Publikováno v:
Frontiers in Nanotechnology, Vol 3 (2021)
The transport of nutrients, xenobiotics, and signaling molecules across biological membranes is essential for life. As gatekeepers of cells, membrane proteins and nanopores are key targets in pharmaceutical research and industry. Multiple techniques
Externí odkaz:
https://doaj.org/article/f70b65d35b7645b1941ae30590712a02
Autor:
Tim Diederichs, Genevieve Pugh, Adam Dorey, Yongzheng Xing, Jonathan R. Burns, Quoc Hung Nguyen, Marc Tornow, Robert Tampé, Stefan Howorka
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nanopores have a wide range of applications in the field of sensing. Here the authors report on synthetic nanopores made of DNA and designed for the transit of folded proteins across membranes to allow for biosensing.
Externí odkaz:
https://doaj.org/article/11af9a52e62f4231905b9f9d4ad4441c