Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Robert T. Warren"'
Autor:
Kaitlin A. Read, Devin M. Jones, Srijana Pokhrel, Emily D. S. Hales, Aditi Varkey, Jasmine A. Tuazon, Caprice D. Eisele, Omar Abdouni, Abbey Saadey, Melissa R. Leonard, Robert T. Warren, Michael D. Powell, Jeremy M. Boss, Emily A. Hemann, Jacob S. Yount, Gang Xin, Hazem E. Ghoneim, Chan-Wang J. Lio, Aharon G. Freud, Patrick L. Collins, Kenneth J. Oestreich
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
The regulation and direction of CD4+ T cells into phenotypic and functional lineages is coordinated by a complex set of mechanisms. Here the authors show a role for Aiolos as a regulator of the CD4+ cytotoxic and T follicular helper lineages.
Externí odkaz:
https://doaj.org/article/db3616878fde4edbb2df4e62fd0817bd
Autor:
Jason M. Zimmerer, Jing L. Han, Chelsea M. Peterson, Qiang Zeng, Bryce A. Ringwald, Clarissa Cassol, Sachi Chaudhari, Madison Hart, Jessica Hemminger, Anjali Satoskar, Mahmoud Abdel-Rasoul, Jiao-Jing Wang, Robert T. Warren, Zheng J. Zhang, Christopher K. Breuer, Ginny L. Bumgardner
Publikováno v:
Am J Transplant
CCR5 KO kidney transplant (KTx) recipients are extraordinarily high alloantibody producers and develop pathology that mimics human antibody-mediated rejection (AMR). C57BL/6 and CCR5 KO mice (H-2(b)) were transplanted with A/J kidneys (H-2(a)); selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4ccc1ef7cde2c389259d59da8fac2a9
https://doi.org/10.1111/ajt.16988
https://doi.org/10.1111/ajt.16988
Autor:
Jing Han, Madison M Hart, Ginny L. Bumgardner, Robert T. Warren, Chelsea M Peterson, Bryce A Ringwald, Sachi R Chaudhari, Mahmoud Abdel-Rasoul, Jason M. Zimmerer
Publikováno v:
J Immunol
Hepatocyte transplant represents a treatment for metabolic disorders but is limited by immunogenicity. Our prior work identified the critical role of CD8+ T cells, with or without CD4+ T cell help, in mediating hepatocyte rejection. In this study, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72bd6691be0e085cab8786d555bd82bd
https://doi.org/10.4049/jimmunol.2100334
https://doi.org/10.4049/jimmunol.2100334
Autor:
Jasmine A. Tuazon, Kaitlin A. Read, Bharath K. Sreekumar, Michael J. Yaeger, Sanjay Varikuti, Devin M. Jones, Robert T. Warren, Michael D. Powell, Mustafa N. Rasheed, Elizabeth G. Duncan, Lauren M. Childs, Kymberly M. Gowdy, Kenneth J. Oestreich
The Ikaros zinc finger transcription factor Eos has been commonly implicated in regulatory T cells to promote their immunosuppressive functions. Paradoxically, a new role is emerging for Eos in promoting pro-inflammatory responses of conventional CD4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe3a4a73b0c64015139a42b4ecefef6d
https://doi.org/10.1101/2022.11.02.514868
https://doi.org/10.1101/2022.11.02.514868
Autor:
Alecia Blaszczak, Ginny L. Bumgardner, Jason M. Zimmerer, Thomas A. Pham, Xin L. Liu, Robert T. Warren, Christina L. Avila
Publikováno v:
The Journal of Immunology. 201:3731-3740
Humoral alloimmunity negatively impacts both short- and long-term cell and solid organ transplant survival. We previously reported that alloantibody-mediated rejection of transplanted hepatocytes is critically dependent on host macrophages. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8460146fc91843ddabc67aab97709794
https://doi.org/10.4049/jimmunol.1800333
https://doi.org/10.4049/jimmunol.1800333
Autor:
Srijana Pokhrel, Kaitlin A Read, Devin M Jones, Michael D Powell, Robert T Warren, Kenneth J Oestreich
Publikováno v:
The Journal of Immunology. 208:57.04-57.04
CD4+ central memory T cells (TCM) are key players in recall immune responses and thus are critical to long-term immunity. Despite their importance, much remains to be defined regarding the mechanisms that promote their differentiation and survival. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fffe1c5407f453b9a3e8e8c882a4d60d
https://doi.org/10.4049/jimmunol.208.supp.57.04
https://doi.org/10.4049/jimmunol.208.supp.57.04
Autor:
Kaitlin Read, Srijana Pokhrel, Devin M Jones, Abbey Saadey, Caprice Eisele, Robert T Warren, Patrick Collins, Hazem E. Ghoneim, Aharon Freud, Kenneth J Oestreich
Publikováno v:
The Journal of Immunology. 208:112.20-112.20
CD4+ T follicular helper (TFH) cells are critical for the generation of robust humoral immune responses, as they provide help to B cells to support the generation of both pathogen-neutralizing antibodies and long-lived plasma cell populations. To dat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e48c2faf28862dbebfe04315c47d509
https://doi.org/10.4049/jimmunol.208.supp.112.20
https://doi.org/10.4049/jimmunol.208.supp.112.20
Autor:
Devin M Jones, Kaitlin A Read, Srijana Pokhrel, Emily Hales, Caprice Eisele, Robert T Warren, Patrick Collins, Aharon Freud, Kenneth J Oestreich
Publikováno v:
The Journal of Immunology. 208:166.03-166.03
Classically, CD4+ T cells have been defined as “helper” type cells, providing aid to other immune cell populations via the secretion of cytokines and direct cell-cell interactions. More recently, a subset of CD4+ T cells with cytotoxic capabiliti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f68a70c96a759f8ee2e5469f49a5f2c
https://doi.org/10.4049/jimmunol.208.supp.166.03
https://doi.org/10.4049/jimmunol.208.supp.166.03
Autor:
Steven M. Elzein, Christina Avila, Robert T. Warren, Bryce A Ringwald, Ginny L. Bumgardner, Mahmoud Abdel-Rasoul, Jason M. Zimmerer
Publikováno v:
Transplantation
BACKGROUND: We previously reported the novel activity of alloprimed CD8(+) T cells that suppress post transplant alloantibody production. The purpose of the current study is to investigate the expression and role of CXCR5 on antibody-suppressor CD8(+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95c10af3dca00c7df5521a8e44e3ae1f
https://pubmed.ncbi.nlm.nih.gov/30817404
https://pubmed.ncbi.nlm.nih.gov/30817404
Autor:
Bryce Alan Ringwald, Jason M Zimmerer, Sachi Chaudhari, Jing Han, Chelsea M Peterson, Robert T Warren, Madison Hart, Mahmoud Abdel-Rasoul, Ginny L Bumgardner
Publikováno v:
The Journal of Immunology. 206:28.11-28.11
Hepatocyte transplant (HcTx) is a treatment for metabolic diseases and a bridge to liver transplant but is limited by immunogenicity. Our prior work identified the critical role of CD4-dependent and CD4-independent CD8+ T cells in HcTx rejection. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6ae8b529b020e2e66ce4c80430c496d
https://doi.org/10.4049/jimmunol.206.supp.28.11
https://doi.org/10.4049/jimmunol.206.supp.28.11