Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Robert T. Parfitt"'
Publikováno v:
Journal of Medicinal Chemistry. 28:177-181
The synthesis of 4-alkyl-, 4-aralkyl-, and 4-alkenyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines is described together with some 4,4-disubstituted and 8-hydroxy derivatives. Evidence of the stereochemistry of the 4-substituent was from 1H and 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e17843bfe0157244b823a8d132dcaa8
https://doi.org/10.1021/jm00380a005
https://doi.org/10.1021/jm00380a005
Publikováno v:
Enzyme and Microbial Technology. 6:471-475
Cell-free extracts have been prepared from the fungus Cunninghamella bainieri which retain high levels of N -demethylase activity against codeine and other drug molecules. Extraction required both disruption and solubilization, indicating that the N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52e0bd66adad06edcc3bf9e088d1b527
https://doi.org/10.1016/0141-0229(84)90099-1
https://doi.org/10.1016/0141-0229(84)90099-1
Publikováno v:
Journal of Microbiological Methods. 3:21-26
Gas-liquid chromatography methpods were developed for the determination of transformation products and unaltered substrate in mirobial N -dealkylation studies with drug molecules. the microorganism used was the fungus Cunninghemella echinulata , and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6d9c2bb3cd99428d873d819c757f13f
https://doi.org/10.1016/0167-7012(84)90041-1
https://doi.org/10.1016/0167-7012(84)90041-1
Publikováno v:
Applied Microbiology and Biotechnology. 19:247-251
Selected microorganisms were screened for their ability to N-dealkylate drug molecules. The compounds studied enabled the investigation of N-alkyl groups in different chemical environments, including alkylaminoalkyl chains, saturated cyclic structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5cea348b99c186684bc4b6b5d1e333e
https://doi.org/10.1007/bf00251845
https://doi.org/10.1007/bf00251845
Autor:
Robert T. Parfitt, Shabir K. Hirani
Publikováno v:
Journal of Heterocyclic Chemistry. 24:489-494
The synthesis of series of 1α and 1β-alkylamino-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines from the corresponding acylamino intermediates is described. Cyclization of the 1β-chloromethylamido derivative 20 to the novel bridged benzomorphan 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb78b654c82aa16a9a8e5aa58eae8259
https://doi.org/10.1002/jhet.5570240235
https://doi.org/10.1002/jhet.5570240235
Publikováno v:
Analytica Chimica Acta. 163:175-183
Codeine was synthesized with 90% enrichment of the N -methyl group with carbon-13. N -Demethylation of this substrate by cell-free extracts of Cunninghamella bainieri in an n.m.r, tube gave norcodeine and 13 C-labelled formaldehyde. Fourier-transform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70e7b627d9a809a3c5683f49bdc5788d
https://doi.org/10.1016/s0003-2670(00)81506-8
https://doi.org/10.1016/s0003-2670(00)81506-8
Publikováno v:
The Journal of Organic Chemistry. 32:419-422
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a76c38147a01d0736e472ce03c6c3627
https://doi.org/10.1021/jo01288a035
https://doi.org/10.1021/jo01288a035
Autor:
Robert T. Parfitt, Susan M. Walters
Publikováno v:
Journal of Medicinal Chemistry. 14:565-568
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fc1df175f9a3198ad36c3d8425842ab
https://doi.org/10.1021/jm00289a002
https://doi.org/10.1021/jm00289a002
Publikováno v:
Organic Mass Spectrometry. 13:341-343
A combination of electron impact, chemical ionization, field desorption and field ionization mass spectrometry has been employed to demonstrate that the LAH reduction product of 3H-1,2-benzodithiole-3-thione is the dimer, dibenzo[c,h]-3H,10H-dihydro-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6dd89db5d3d0311cc85c25473f3fce7a
https://doi.org/10.1002/oms.1210130609
https://doi.org/10.1002/oms.1210130609
Publikováno v:
Phytochemistry. 19:698-700
From the seed of fenugreek, a new glycoside has been isolated and shown to have the structure, (25 S )- 22 - O - methyl-5α-furostan-3β,22,26-triol 3- O -α-rhamnopyranosyl(1→2)[-β- d -glucopyranosyl (1→3)]-β- d - glucopyranoside-26- O -β- d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcf4327542feac5f2240357cad298683
https://doi.org/10.1016/0031-9422(80)87046-4
https://doi.org/10.1016/0031-9422(80)87046-4