Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Robert T. Luedtke"'
Autor:
Kristoffer Sahlholm, Michelle Taylor, Chi-Chang Weng, Kuiying Xu, Suzy A. Griffin, Daniel A. Jacome, Robert T. Luedtke, Robert H. Mach, Sean W. Reilly
Publikováno v:
Journal of Medicinal Chemistry. 60:9905-9910
A series of potent and selective D3 receptor (D3R) analogues with diazaspiro alkane cores were synthesized. Radioligand binding of compounds 11, 14, 15a, and 15c revealed favorable D3R affinity (Ki = 12–25.6 nM) and were highly selective for D3R vs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e9ee65de072d1172b609d91d73eee5e
https://doi.org/10.1021/acs.jmedchem.7b01248
https://doi.org/10.1021/acs.jmedchem.7b01248
Autor:
B. C. Nolan, T. H. C. Cheung, Janet L. Neisewander, Natalie A. Peartree, Robert T. Luedtke, J. P. Durbin, Lindsey R. Hammerslag, Robert H. Mach, Suzanne M. Weber
Publikováno v:
Neuropharmacology. 63:1346-1359
This study examined cocaine self-administration after pretreatments with three structurally related compounds that bind selectively to dopamine D3 receptors (D3Rs) relative to the D2 receptor subtype (D2Rs) and exhibit varying intrinsic activities in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b87260cd02b32a5311ee945ad098395
https://doi.org/10.1016/j.neuropharm.2012.08.011
https://doi.org/10.1016/j.neuropharm.2012.08.011
Autor:
Brandi L. Blaylock, Robert W. Gould, Michael A. Nader, Robert T. Luedtke, A. Banala, Peter Grundt, Amy Hauck Newman
Publikováno v:
Neuropsychopharmacology. 36:1104-1113
Although dopamine D(3) receptors have been associated with cocaine abuse, little is known about the consequences of chronic cocaine on functional activity of D(3) receptor-preferring compounds. This study examined the behavioral effects of D(3) recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::facd872f4258b5bd0973eb9e6d790c2a
https://doi.org/10.1038/npp.2010.248
https://doi.org/10.1038/npp.2010.248
Autor:
Raghu R. Krishnamoorthy, Shao-Hua Yang, Alena Z. Minton, Robert T. Luedtke, Shaoqing He, Dorota L. Stankowska, M. Jiang, Colby Brownlee, Brett H. Mueller, Hai Ying Ma, Nitasha R. Phatak
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43199 (2012)
PLoS ONE
PLoS ONE
Glaucoma is an optic neuropathy, commonly associated with elevated intraocular pressure (IOP) characterized by optic nerve degeneration, cupping of the optic disc, and loss of retinal ganglion cells which could lead to loss of vision. Endothelin-1 (E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a551dc0cfe55e614a1441bb62991329e
http://europepmc.org/articles/PMC3423444?pdf=render
http://europepmc.org/articles/PMC3423444?pdf=render
Autor:
Paula E. Park, John P. Durbin, Martin Weber, Wei Li Chang, Robert H. Mach, Robert T. Luedtke, Neal R. Swerdlow
Publikováno v:
Pharmacology, biochemistry, and behavior. 93(2)
Prepulse inhibition of startle (PPI) is an operational measure of sensorimotor gating that is impaired in schizophrenia. Treatment with mixed dopamine D2/D3 antagonists diminishes schizophrenia symptoms, and opposes dopamine agonist-induced PPI defic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e5a4d69d4f9c2a3539e33b12b87098e
https://pubmed.ncbi.nlm.nih.gov/19426754
https://pubmed.ncbi.nlm.nih.gov/19426754