Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Robert T. Hillman"'
Autor:
Thomas Welte, Veena Vuttaradhi, Eleonora Khlebus, Barrett Lawson, Robert T. Hillman, Nghi Nguyen, Mary Sobieski, Reid T. Powell, Clifford Stephan
Publikováno v:
Cancer Research. 83:453-453
Background: Nearly all adult-type granulosa cell tumors of the ovary (aGCTs) carry the same oncogenic mutation affecting the second winged helix domain of the Forkhead family transcription factor FOXL2 (c.C402G; p.C134W). There are no currently avail
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91d1a99f03f70132ef0dd931af0fa2e6
https://doi.org/10.1158/1538-7445.am2023-453
https://doi.org/10.1158/1538-7445.am2023-453
Autor:
David M. Gershenson, Charlotte C. Sun, Shannon N. Westin, Mostafa Eyada, Lauren P. Cobb, Lisa C. Nathan, Anil K. Sood, Anais Malpica, Robert T. Hillman, Kwong K. Wong
Publikováno v:
Gynecologic oncology. 165(3)
Low-grade serous carcinoma (LGSOC) is a rare epithelial ovarian/peritoneal cancer characterized by younger age at diagnosis, relative chemoresistance, prolonged overall survival (OS), and mutations in the mitogen activated protein kinase (MAPK) pathw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b128d3af18b3165f6f8c0004ee6a18
https://pubmed.ncbi.nlm.nih.gov/35606067
https://pubmed.ncbi.nlm.nih.gov/35606067
Autor:
Kathleen M. Schmeler, Jagannadha K. Sastry, Andrea Y. Delgado Medrano, Jennifer A. Wargo, Rebecca J. Previs, Patricia J. Eifel, Nadim J. Ajami, Stephanie Dorta-Estremera, Anuja Jhingran, Vancheswaran Gopalakrishnan, Lois M. Ramondetta, Amir A. Jazaeri, Diane Hutchinson, Cullen M. Taniguchi, M. Frumovitz, Travis Solley, Aradhana Venkatesan, Andrew M. Futreal, Ann H. Klopp, Megan Mikkelson, Lauren E. Colbert, Stephen M. Hahn, Robert T. Hillman, Pablo C. Okhuysen, Joseph Petrosino, Shane R. Stecklein, Geena Mathew, Beth A. Helmink
Publikováno v:
SSRN Electronic Journal.
Composition of the intestinal microbiome has been shown to impact generation of a tumor-specific immune response following chemotherapy and immune checkpoint blockade. We hypothesized that the local and intestinal microbiota may also impact immune ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fb5a71ba9f4a9ecd038f57a09e483ed
https://doi.org/10.2139/ssrn.3199993
https://doi.org/10.2139/ssrn.3199993
Autor:
Eric C. Olivares, Michele P. Calos, Thomas W. Chalberg, Bhaskar Thyagarajan, Robert T. Hillman, Patrick J. Kirby, Juergen Hoelters, Joylette L. Portlock
Publikováno v:
Journal of Molecular Biology. 357:28-48
The site-specific integrase from bacteriophage phiC31 functions in mammalian cells and is being applied for genetic engineering, including gene therapy. The phiC31 integrase catalyzes precise, unidirectional recombination between its 30-40-bp attP an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6101c0e076dc1103df82b6bd44ccad97
https://doi.org/10.1016/j.jmb.2005.11.098
https://doi.org/10.1016/j.jmb.2005.11.098
Autor:
Bo-qing Zhu, Richard E Sievers, Amanda EM Browne, Robert T Hillman, Kamel Chair, Randall J Lee, Kanu Chatterjee, Stanton A Glantz, William W Parmley
Publikováno v:
Journal of the Renin-Angiotensin-Aldosterone System, Vol 3 (2002)
Introduction Both second hand smoke (SHS) and the renin-angiotensin system (RAS) contribute to endothelial dysfunction and increased infarct size in a rat ischaemia-reperfusion model. However, the potential interaction between SHS and the RAS is unkn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47edea7a7e25861cb7684f2b970c4c40
https://doi.org/10.3317/jraas.2002.009
https://doi.org/10.3317/jraas.2002.009
Autor:
Christopher L. Chavez, Lauren E. Woodard, Jacqueline N. Chu, Michele P. Calos, Robert T. Hillman, Annahita Keravala, Timothy R. Stowe
The ΦC31 integrase system provides genomic integration of plasmid DNA that may be useful in gene therapy. For example, the ΦC31 system has been used in combination with hydrodynamic injection to achieve long-term expression of factor IX in mouse li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f1e504633f0de77124e9bb82175b48
https://europepmc.org/articles/PMC2974851/
https://europepmc.org/articles/PMC2974851/
Publikováno v:
Gene therapy
Summary Phage φC31 integrase is a recombinase that can be expressed in mammalian cells to integrate plasmids carrying an attB sequence into the genome at specific pseudo attP locations. We demonstrate by immunofluoresence that wild-type φC31 integr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7442f91c5399a6ff8ff2fe45ab3268a3
https://pubmed.ncbi.nlm.nih.gov/19847205
https://pubmed.ncbi.nlm.nih.gov/19847205
Publikováno v:
Molecular Therapy. 13
Top of pageAbstract Bacteriophage |[phiv]|C31 integrase is able to catalyze a unidirectional, site-specific DNA recombination reaction. Constrained target sequence preference, combined with an ability to function in a eukaryotic environment, have mad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eacea43e01247e60d47e9366772652ee
Autor:
Boqing Zhu, Richard E. Slevers, Amanda E. Browne, Robert T. Hillman, Kamel Chair, Randall J. Lee, Kanu Chatterjee, William Grossman, Stanton A. Glantz, William W. Parmley
Publikováno v:
Journal of the American College of Cardiology. 39
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05bff213dcb04da6757892c08f359721
Publikováno v:
Molecular Therapy. 13:S332
The phiC31 integrase system effectively integrates plasmid DNA carrying an attB site into a limited number of endogenous pseudo attP sites in mammalian genomes, leading to robust, long-term expression of transgenes. The phiC31 system has been used to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ce5922ab003e2fb81650aa642396535
https://doi.org/10.1016/j.ymthe.2006.08.949
https://doi.org/10.1016/j.ymthe.2006.08.949