Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Robert T. Gale"'
Autor:
Michele D Kattke, Jason E Gosschalk, Orlando E Martinez, Garima Kumar, Robert T Gale, Duilio Cascio, Michael R Sawaya, Martin Philips, Eric D Brown, Robert T Clubb
Publikováno v:
PLoS Pathogens, Vol 15, Iss 4, p e1007723 (2019)
Staphylococcus aureus and other bacterial pathogens affix wall teichoic acids (WTAs) to their surface. These highly abundant anionic glycopolymers have critical functions in bacterial physiology and their susceptibility to β-lactam antibiotics. The
Externí odkaz:
https://doaj.org/article/7f0a8bf7318548a9bcafd1c36499c5bd
Autor:
Solmaz Sobhanifar, Liam J Worrall, Dustin T King, Gregory A Wasney, Lars Baumann, Robert T Gale, Michael Nosella, Eric D Brown, Stephen G Withers, Natalie C J Strynadka
Publikováno v:
PLoS Pathogens, Vol 12, Iss 12, p e1006067 (2016)
In recent years, there has been a growing interest in teichoic acids as targets for antibiotic drug design against major clinical pathogens such as Staphylococcus aureus, reflecting the disquieting increase in antibiotic resistance and the historical
Externí odkaz:
https://doaj.org/article/5145b8a01c064e478e04e7f807981379
Autor:
Maya A. Farha, Lindsey A. Carfrae, Nicholas G. Jentsch, Jakob Magolan, Craig R. MacNair, Omar M. El-Halfawy, Eric D. Brown, Robert T. Gale, Xiong Zhang
Publikováno v:
ACS Infectious Diseases. 6:338-346
The spread of antimicrobial resistance continues to be a priority health concern worldwide, necessitating exploration of alternative therapies. Cannabis sativa has long been known to contain antibacterial cannabinoids, but their potential to address
Autor:
Federico I. Rosell, Jean-Pierre Simorre, Natalie C. J. Strynadka, Eric D. Brown, Robert T. Gale, Franco K.K. Li
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, 2020, 295 (9), pp.2629-2639. ⟨10.1074/jbc.RA119.011469⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2020, 295 (9), pp.2629-2639. ⟨10.1074/jbc.RA119.011469⟩
Journal of Biological Chemistry, 2020, 295 (9), pp.2629-2639. ⟨10.1074/jbc.RA119.011469⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2020, 295 (9), pp.2629-2639. ⟨10.1074/jbc.RA119.011469⟩
International audience; Gram-positive bacteria, including major clinical pathogens such as Staphylococcus aureus, are becoming increasingly drug-resistant. Their cell walls are composed of a thick layer of peptidoglycan (PG) modified by the attachmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b56519fda913972ea5cce425b717500
https://hal.univ-grenoble-alpes.fr/hal-03003133
https://hal.univ-grenoble-alpes.fr/hal-03003133
Autor:
Robert T. Gale, Franco K.K. Li, Natalie C. J. Strynadka, Christoph H. Borchers, Eric D. Brown, Evgeniy V. Petrotchenko
Publikováno v:
Journal of Structural Biology. 213:107733
The cell wall of many pathogenic Gram-positive bacteria contains ribitol-phosphate wall teichoic acid (WTA), a polymer that is linked to virulence and regulation of essential physiological processes including cell division. CDP-ribitol, the activated
Autor:
Franco K K, Li, Federico I, Rosell, Robert T, Gale, Jean-Pierre, Simorre, Eric D, Brown, Natalie C J, Strynadka
Publikováno v:
J Biol Chem
Gram-positive bacteria, including major clinical pathogens such as Staphylococcus aureus, are becoming increasingly drug-resistant. Their cell walls are composed of a thick layer of peptidoglycan (PG) modified by the attachment of wall teichoic acid
Autor:
Eric D. Brown, Orlando E. Martinez, Martin L. Phillips, Michael R. Sawaya, Robert T. Clubb, Michele D. Kattke, Robert T. Gale, Duilio Cascio, Garima Kumar, Jason E. Gosschalk
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 15, Iss 4, p e1007723 (2019)
PLoS Pathogens, Vol 15, Iss 4, p e1007723 (2019)
Staphylococcus aureus and other bacterial pathogens affix wall teichoic acids (WTAs) to their surface. These highly abundant anionic glycopolymers have critical functions in bacterial physiology and their susceptibility to β-lactam antibiotics. The
Autor:
Eric D. Brown, Robert T. Gale
Publikováno v:
Current Opinion in Microbiology. 27:69-77
Some of the most successful drugs in the antibiotic pharmacopeia are those that inhibit bacterial cell wall biosynthesis. However, the worldwide spread of bacterial antibiotic resistance has eroded the clinical efficacy of these drugs and the antibio
Publikováno v:
Cell chemical biology. 24(12)
Summary Gram-positive bacteria endow their peptidoglycan with glycopolymers that are crucial for viability and pathogenesis. However, the cellular machinery that executes this function is not well understood. While decades of genetic and phenotypic w
Autor:
Sebastian Hubner, Robert T. Gale, Eric D. Brown, Hannes Link, Letal I. Salzberg, Eric Botella, David Noone, Kevin M. Devine, Susanne Krogh Devine, Jeroen D. C. Codée, Uwe Sauer
Publikováno v:
Molecular Microbiology. 94:1242-1259
The PhoPR two-component signal transduction system controls one of the major responses to phosphate limitation in Bacillus subtilis. When activated it directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall tei