Výsledky vyhledávání - "Robert T. Gale"

Akademický článek

Structure and mechanism of TagA, a novel membrane-associated glycosyltransferase that produces wall teichoic acids in pathogenic bacteria.

Autor: Michele D Kattke, Jason E Gosschalk, Orlando E Martinez, Garima Kumar, Robert T Gale, Duilio Cascio, Michael R Sawaya, Martin Philips, Eric D Brown, Robert T Clubb

Publikováno v: PLoS Pathogens, Vol 15, Iss 4, p e1007723 (2019)

Staphylococcus aureus and other bacterial pathogens affix wall teichoic acids (WTAs) to their surface. These highly abundant anionic glycopolymers have critical functions in bacterial physiology and their susceptibility to β-lactam antibiotics. The

Externí odkaz: https://doaj.org/article/7f0a8bf7318548a9bcafd1c36499c5bd

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Akademický článek

Structure and Mechanism of Staphylococcus aureus TarS, the Wall Teichoic Acid β-glycosyltransferase Involved in Methicillin Resistance.

Autor: Solmaz Sobhanifar, Liam J Worrall, Dustin T King, Gregory A Wasney, Lars Baumann, Robert T Gale, Michael Nosella, Eric D Brown, Stephen G Withers, Natalie C J Strynadka

Publikováno v: PLoS Pathogens, Vol 12, Iss 12, p e1006067 (2016)

In recent years, there has been a growing interest in teichoic acids as targets for antibiotic drug design against major clinical pathogens such as Staphylococcus aureus, reflecting the disquieting increase in antibiotic resistance and the historical

Externí odkaz: https://doaj.org/article/5145b8a01c064e478e04e7f807981379

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Uncovering the Hidden Antibiotic Potential of Cannabis

Autor: Maya A. Farha, Lindsey A. Carfrae, Nicholas G. Jentsch, Jakob Magolan, Craig R. MacNair, Omar M. El-Halfawy, Eric D. Brown, Robert T. Gale, Xiong Zhang

Publikováno v: ACS Infectious Diseases. 6:338-346

The spread of antimicrobial resistance continues to be a priority health concern worldwide, necessitating exploration of alternative therapies. Cannabis sativa has long been known to contain antibacterial cannabinoids, but their potential to address

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f973ffea8c2fcd19160c257eaee23210
https://doi.org/10.1021/acsinfecdis.9b00419

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Crystallographic analysis of Staphylococcus aureus LcpA, the primary wall teichoic acid ligase

Autor: Federico I. Rosell, Jean-Pierre Simorre, Natalie C. J. Strynadka, Eric D. Brown, Robert T. Gale, Franco K.K. Li

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, 2020, 295 (9), pp.2629-2639. ⟨10.1074/jbc.RA119.011469⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2020, 295 (9), pp.2629-2639. ⟨10.1074/jbc.RA119.011469⟩

International audience; Gram-positive bacteria, including major clinical pathogens such as Staphylococcus aureus, are becoming increasingly drug-resistant. Their cell walls are composed of a thick layer of peptidoglycan (PG) modified by the attachmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b56519fda913972ea5cce425b717500
https://hal.univ-grenoble-alpes.fr/hal-03003133

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Crystallographic analysis of TarI and TarJ, a cytidylyltransferase and reductase pair for CDP-ribitol synthesis in Staphylococcus aureus wall teichoic acid biogenesis

Autor: Robert T. Gale, Franco K.K. Li, Natalie C. J. Strynadka, Christoph H. Borchers, Eric D. Brown, Evgeniy V. Petrotchenko

Publikováno v: Journal of Structural Biology. 213:107733

The cell wall of many pathogenic Gram-positive bacteria contains ribitol-phosphate wall teichoic acid (WTA), a polymer that is linked to virulence and regulation of essential physiological processes including cell division. CDP-ribitol, the activated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bb9fe907d7897648ef0062e5af16551
https://doi.org/10.1016/j.jsb.2021.107733

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Crystallographic analysis of

Autor: Franco K K, Li, Federico I, Rosell, Robert T, Gale, Jean-Pierre, Simorre, Eric D, Brown, Natalie C J, Strynadka

Publikováno v: J Biol Chem

Gram-positive bacteria, including major clinical pathogens such as Staphylococcus aureus, are becoming increasingly drug-resistant. Their cell walls are composed of a thick layer of peptidoglycan (PG) modified by the attachment of wall teichoic acid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::38790c40372208e0b72ba3495b7dc77f
https://pubmed.ncbi.nlm.nih.gov/31969390

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Structure and mechanism of TagA, a novel membrane-associated glycosyltransferase that produces wall teichoic acids in pathogenic bacteria

Autor: Eric D. Brown, Orlando E. Martinez, Martin L. Phillips, Michael R. Sawaya, Robert T. Clubb, Michele D. Kattke, Robert T. Gale, Duilio Cascio, Garima Kumar, Jason E. Gosschalk

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 15, Iss 4, p e1007723 (2019)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d387492268808ebf8fc2c3b1c6383f05
https://pubmed.ncbi.nlm.nih.gov/31002736

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New chemical tools to probe cell wall biosynthesis in bacteria

Autor: Eric D. Brown, Robert T. Gale

Publikováno v: Current Opinion in Microbiology. 27:69-77

Some of the most successful drugs in the antibiotic pharmacopeia are those that inhibit bacterial cell wall biosynthesis. However, the worldwide spread of bacterial antibiotic resistance has eroded the clinical efficacy of these drugs and the antibio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d6436f55f7966a045f9710cf491b1b
https://doi.org/10.1016/j.mib.2015.07.013

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