Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Robert T. Currin"'
Autor:
Sigrid Bachmann, Robert T. Currin, Henry D. Connor, Ronald P. Mason, John J. Lemasters, Wenshi Gao, Ronald G. Thurman
Publikováno v:
Cell Biology of Trauma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3c64906f047d3d571be1ce083699c60
https://doi.org/10.1201/9781003067801-24
https://doi.org/10.1201/9781003067801-24
Autor:
Andrey P. Tikunov, Ekhson Holmuhamedov, Robert T. Currin, Peter Pediaditakis, Zhi Zhong, Venkat K. Ramshesh, Tom P. Theruvath, John J. Lemasters
Publikováno v:
Hepatology. 47:236-246
Graft failure after liver transplantation may involve mitochondrial dysfunction. We examined whether prevention of mitochondrial injury would improve graft function. Orthotopic rat liver transplantation was performed after 18 hours' cold storage in U
Publikováno v:
American Journal of Transplantation. 7:1103-1111
ATP decreases markedly in small-for-size liver grafts. This study tested if the mitochondrial permeability transition (MPT) underlies dysfunction of small-for-size livers. Half-size livers were implanted into recipients of about twice the donor weigh
Publikováno v:
Transplantation Proceedings. 38:3351-3357
Endothelial nitric oxide synthase (eNOS) plays a role in microcirculatory and immunomodulatory responses after warm ischemia/reperfusion. We hypothesized that eNOS is essential to maintain microcirculation, attenuate macrophage infiltration and decre
Autor:
Robert Schoonhoven, Robert T. Currin, John J. Lemasters, Xing-Xi Peng, Harold E. Mekeel, Ming Yin
Publikováno v:
Transplantation. 73:1410-1420
BACKGROUND Kidney damage caused by cold ischemia-reperfusion injury promotes adverse outcomes after renal transplantation. The purpose of this study was to determine whether Carolina rinse solution (CRS) used at the end of cold ischemic storage decre
Autor:
Xing-Xi Peng, Robert T. Currin, Harold E. Mekeel, Ming Yin, John J. Lemasters, Robert Schoonhoven
Publikováno v:
Renal Failure. 24:147-163
Kidneys preserved for transplantation surgery sustain injuries caused by cold ischemia during storage. Additionally, kidneys harvested from non-heart-beating donors encounter the stress of warm ischemia. The aim of this study was to determine the spe
Publikováno v:
Toxicology Letters. 117:95-100
The purpose of this study was to evaluate the roles of Kupffer cells, prostaglandin biosynthesis, and glycolytic metabolism in accelerated anoxic cell killing by hyperosmolar stress. Isolated rat livers were perfused with anoxic normosmolar Krebs-Hei
Autor:
Sunao Kawano, Jane C. Caldwell-Kenkel, Sigrid Bachmann, Yoshiyuki Takei, Ronald G. Thurman, Steven N. Lichtman, John J. Lemasters, Robert T. Currin
Publikováno v:
Transplantation. 62:1549-1558
The critical injury causing graft failure after prolonged liver storage involves reperfusion-induced killing of sinusoidal endothelial cells and activation of Kupffer cells. Treatment of stored livers with Carolina rinse solution (CRS) prevents endot
Autor:
Wenshi Gao, Sigrid Bachmann, Robert T. Currin, Ronald G Thurman, Xing-Xi Peng, John J. Lemasters
Publikováno v:
Journal of Gastroenterology and Hepatology. 10:S84-S87
In rat models of liver preservation, the primary event leading to liver graft failure after cold storage is a reperfusion injury causing damage to sinusoidal endothelial cells and activation of Kupffer cells (KC). After storage for longer than 16 h i
Publikováno v:
Transplantation. 59:1537-1541
Previously, pentoxifylline treatment of graft recipients was shown to protect against liver graft failure from storage/reperfusion injury after orthotopic rat liver transplantation. To determine whether pentoxifylline also protects against normotherm