Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Robert T. Cass"'
Autor:
Thomas H. Pillow, Yuzhong Deng, Katherine R. Kozak, Peter S. Dragovich, Liling Liu, Robert T. Cass, Yichin Liu, S. Cyrus Khojasteh, Aimee Fourie-O'Donohue, Donglu Zhang, Jack Sadowsky, Cornelis E. C. A. Hop
Publikováno v:
Drug Metabolism and Disposition. 47:1156-1163
In cells, catalytic disulfide cleavage is an essential mechanism in protein folding and synthesis. However, detailed enzymatic catalytic mechanism relating cleavage of disulfide bonds in xenobiotics is not well understood. This study reports an enzym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9e8affd3c247730a18fefcdc3bf9965
https://doi.org/10.1124/dmd.118.086132
https://doi.org/10.1124/dmd.118.086132
Autor:
Ryan Cirz, Robert T. Cass, Matthew A. Metz, Corwin F. Kostrub, Melanie Doyle-Eisele, Robert Sherwood, William Mega
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:6429-6439
The efficacy of plazomicin for pneumonic plague was evaluated in a non-human primate model. African Green monkeys challenged with a lethal aerosol of Yersinia pestis [median (range) of 98 (15–331) LD50s] received placebo (n=12) or ‘humanized’ d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37987b8375252516c45f6cf02ddced90
https://doi.org/10.1016/j.bmc.2016.08.049
https://doi.org/10.1016/j.bmc.2016.08.049
Autor:
George L. Drusano, Robert T. Cass, Ryan Cirz, Henry S. Heine, Lara Chuvala, Arnold Louie, Renaldo Riggins
Publikováno v:
Antimicrobial Agents and Chemotherapy. 60:1834-1840
The objective of this study was to evaluate the natural history and pathogenesis of Francisella tularensis in a murine model of inhalational tularemia with the SchuS4 strain. Before the efficacy of antimicrobials could be assessed in this model, furt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d2dc3851e14265ace411d0354f26eb2
https://doi.org/10.1128/aac.02887-15
https://doi.org/10.1128/aac.02887-15
Autor:
Xingyu Lin, Guosheng Wu, Yuen Po-Wai, Zhonghua Pei, Kevin DeMent, Benjamin D. Sellers, Yichin Liu, Georgia Hatzivassiliou, Rohan Mendonca, Richard Pastor, Robert T. Cass, Lewis J. Gazzard, Leanne Goon, Amy Gustafson, Erica VanderPorten, Yamin Zhang
Publikováno v:
ACS medicinal chemistry letters. 9(5)
[Image: see text] Tryptophan 2,3-dioxygenase 2 (TDO2) catalyzes the conversion of tryptophan to the immunosuppressive metabolite kynurenine. TDO2 overexpression has been observed in a number of cancers; therefore, TDO inhibition may be a useful thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fac58803f5a2dd5c9321ca3b3cf7803
https://pubmed.ncbi.nlm.nih.gov/29795752
https://pubmed.ncbi.nlm.nih.gov/29795752
Autor:
Ryan Cirz, Lara Chuvala, George L. Drusano, Renaldo Riggins, Henry S. Heine, Robert T. Cass, Arnold Louie, Gregory Hurteau
Publikováno v:
Antimicrobial Agents and Chemotherapy. 57:2010-2015
After a relatively short untreated interval, pneumonic plague has a mortality approaching 100%. We employed a murine model of aerosol challenge with Yersinia pestis to investigate the early course of pneumonic plague in the lung, blood, and spleen. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55ce063fd360cf96b891bc84a0fa2994
https://doi.org/10.1128/aac.02504-12
https://doi.org/10.1128/aac.02504-12
Autor:
M. Allan Jaochico, Jacob Z. Chen, Joachim Rudolf, Teresa Mulder, S. Cyrus Khojasteh, Peter W. Fan, Kirsten Messick, Robert T. Cass, Lesley J. Murray, Wendy Lee, Shannon Liu, Matthew Wright, Matthew R. Durk, Nicole Valle, Hank La, James J. Crawford, Ning Liu
Publikováno v:
Drug Metabolism Letters
Background: Significant under-prediction of in vivo clearance in rat was observed for a potent p21-activated kinase (PAK1) inhibitor, GNE1. Objective: Rate-determining (rapid uptake) and rate-limiting (slow excretion) steps in systemic clearance and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3cd6e0f5d3f0cd10fd2e22896eb4e47
https://pubmed.ncbi.nlm.nih.gov/27063863
https://pubmed.ncbi.nlm.nih.gov/27063863
Publikováno v:
Rapid Communications in Mass Spectrometry. 15:406-412
A novel high-performance liquid chromatography tandem mass spectrometry (LC/MS/MS) method is described for the determination of vancomycin in serum and urine. After the addition of internal standard (teicoplanin), serum and urine samples were directl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40bfd9b240186551c827900b1ee1659b
https://doi.org/10.1002/rcm.246
https://doi.org/10.1002/rcm.246
Autor:
Kenneth J. Tack, Carter D. Brooks, Don Young, Marie T. Borin, Robert T. Cass, Jon B. Bruss, Nancy A. Havrilla
ACHN-490 is an aminoglycoside with activity against multidrug-resistant pathogens, including those resistant to currently used aminoglycosides. Two randomized, double-blind, placebo-controlled clinical studies investigated the pharmacokinetics (PK),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2abf7c3f7bf9dfcf2a4ce280367cac9
https://europepmc.org/articles/PMC3232771/
https://europepmc.org/articles/PMC3232771/
Autor:
Eliana S. Armstrong, Corwin F. Kostrub, Robert T. Cass, Heinz E. Moser, Alisa W. Serio, George H. Miller
Publikováno v:
Antibiotic Discovery and Development ISBN: 9781461413998
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d27f0e99714420fc9909bc75a1151e1
https://doi.org/10.1007/978-1-4614-1400-1_7
https://doi.org/10.1007/978-1-4614-1400-1_7
Autor:
Qiufeng Gao, Jeffrey M. Hubbard, Terry Wu, Joey Leung, Donald E. Schmidt, Robert T. Cass, Koné Kaniga, Dane E. Karr, Patrick P. Humphrey, Deborah L. Higgins, Erik Sandvik, Kevin M. Krause, Bret M. Benton, Dmitri Debabov, Ray Chang
Publikováno v:
Antimicrobial agents and chemotherapy. 49(3)
The emergence and spread of multidrug-resistant gram-positive bacteria represent a serious clinical problem. Telavancin is a novel lipoglycopeptide antibiotic that possesses rapid in vitro bactericidal activity against a broad spectrum of clinically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8345b0eb3746c9bbf1cf5eb1e291d339
https://pubmed.ncbi.nlm.nih.gov/15728913
https://pubmed.ncbi.nlm.nih.gov/15728913