Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Robert T. Cartee"'
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 15, Iss 6, Pp 1310-1316 (2019)
Typhax is an investigational typhoid fever vaccine candidate that was GMP manufactured applying Protein Capsular Matrix Vaccine (PCMV) technology. It consists of Vi polysaccharide antigen, derived from S. Typhi, non-covalently entrapped in a glutaral
Externí odkaz:
https://doaj.org/article/fbfd1a19c87b421c8195c1660aafc381
Autor:
Robert T Cartee, Ann Thanawastien, Thomas J Griffin Iv, John J Mekalanos, Stephan Bart, Kevin P Killeen
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 1, p e0007912 (2020)
BACKGROUND:Typhoid fever remains a significant cause of morbidity and mortality in developing countries especially in children ≤5 years old. Although the widely available unconjugated Vi polysaccharide vaccines are efficacious, they confer limited,
Externí odkaz:
https://doaj.org/article/2a50a6751c374121b9263e76863bbf71
Autor:
Rodney K. Tweten, Robert T. Cartee, Laurel A. Haines, Stephen I. Pelton, Ann Thanawastien, Kevin P. Killeen, Kelsey E. Joyce
Publikováno v:
Vaccine
Pneumolysin is a highly conserved, cholesterol-dependent cytolysin that is an important Streptococcus pneumoniae virulence factor and an attractive target for vaccine development. To attenuate pneumolysin toxicity, a genetic toxoid was constructed wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7301ed964fc47b86ee5939bb3b0bd45
http://europepmc.org/articles/PMC8237519
http://europepmc.org/articles/PMC8237519
Autor:
John J. Mekalanos, Kevin P. Killeen, Robert T. Cartee, Thomas J. Griffin, Stephan Bart, Ann Thanawastien
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 1, p e0007912 (2020)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
Background Typhoid fever remains a significant cause of morbidity and mortality in developing countries especially in children ≤5 years old. Although the widely available unconjugated Vi polysaccharide vaccines are efficacious, they confer limited,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee109d7f67a1121f7283b7faf43bd700
https://doaj.org/article/2a50a6751c374121b9263e76863bbf71
https://doaj.org/article/2a50a6751c374121b9263e76863bbf71
Publikováno v:
Hum Vaccin Immunother
Typhax is an investigational typhoid fever vaccine candidate that was GMP manufactured applying Protein Capsular Matrix Vaccine (PCMV) technology. It consists of Vi polysaccharide antigen, derived from S. Typhi, non-covalently entrapped in a glutaral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2225f58ad18f522007534cb7c4f5f856
https://pubmed.ncbi.nlm.nih.gov/31021700
https://pubmed.ncbi.nlm.nih.gov/31021700
Autor:
Ronald D. Hood, Robert T. Cartee, Margaret Dean Johnson, David A. Vaccari, Oneil A. Wright, Altan Ahmed, Hana' Al-Ebous
Publikováno v:
Birth Defects Research Part A: Clinical and Molecular Teratology. 85:822-827
BACKGROUND: Altered levels of inositol phosphate in the central nervous system (CNS) are hypothesized to produce distorted brain signaling and lead to numerous neurologic maladies. Little is known of mechanisms controlling the complex metabolic flux
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbd7860d27b61a077b4d9e6fcec79ee9
https://doi.org/10.1002/bdra.20608
https://doi.org/10.1002/bdra.20608
Publikováno v:
Journal of Biological Chemistry. 284:11826-11835
The processive reaction mechanisms of β-glycosyl-polymerases are poorly understood. The cellubiuronan synthase of Streptococcus pneumoniae catalyzes the synthesis of the type 3 capsular polysaccharide through the alternate additions of β-1,3-Glc an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12df7cf18897207ac4f102dd601110af
https://doi.org/10.1074/jbc.m900386200
https://doi.org/10.1074/jbc.m900386200
Publikováno v:
Applied and Environmental Microbiology. 73:7150-7154
Putative N -acetylmuramyl- l -alanine amidase genes from LambdaSa1 and LambdaSa2 prophages of Streptococcus agalactiae were cloned and expressed in Escherichia coli . The purified enzymes lysed the cell walls of Streptococcus agalactiae , Streptococc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::015f14889224dd0b131f4e7466333987
https://doi.org/10.1128/aem.01783-07
https://doi.org/10.1128/aem.01783-07
Capsular polysaccharides are the primary antigenic components involved in protective immunity against encapsulated bacterial pathogens. Although immunization of adolescents and adults with polysaccharide antigens has reduced pathogen disease burden,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313577a7d8e6b1d59143a7dfe6c093e7
https://europepmc.org/articles/PMC4364189/
https://europepmc.org/articles/PMC4364189/
Publikováno v:
Journal of Bacteriology. 185:6057-6066
CpsA, CpsB, CpsC, and CpsD are part of a tyrosine phosphorylation regulatory system involved in modulation of capsule synthesis in Streptococcus pneumoniae and many other gram-positive and gram-negative bacteria. Using an immunoblotting technique, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdf392df8774f55fe40bd7c8f919c7c9
https://doi.org/10.1128/jb.185.20.6057-6066.2003
https://doi.org/10.1128/jb.185.20.6057-6066.2003