Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Robert T. C. Brownlee"'
Autor:
Rebecca A. Bilardi, Don R. Phillips, Robert T. C. Brownlee, Lonnie P. Swift, Andrew James. Box, Suzanne M. Cutts, Ken-ichi Kimura, Damian M. Spencer
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 10:70-77
Barminomycin is a member of the anthracycline class of anticancer agents and was originally discovered as a pink/red complex with DNA and RNA and named SN-07. The chromophore was subsequently separated from the nucleic acids by nuclease digestion and
Publikováno v:
Journal of Chemical Theory and Computation. 5:2886-2897
A novel docking protocol using a long, all atom molecular dynamics (MD) simulation, in an explicit solvent medium, without using any distance constraints is presented. This MD docking protocol is able to dock ligands, based on the C-terminal domain (
Publikováno v:
Synthesis. 2009:1991-1998
N-But-3-enyl-α- and β-amino acids can be prepared by cleaving 1,3-oxazolidin-5-ones and 1,3-oxazinan-6-ones in the presence of allylsilanes and boron trifluoride etherate at room temperature in good to excellent yields.
Autor:
P. Mark Hogarth, Bruce D. Wines, Paul A. Ramsland, Angela C. Cendron, Robert T. C. Brownlee, Geoffrey A. Pietersz
Publikováno v:
Molecular Immunology. 45:307-319
A disulphide-constrained peptide that binds to the low affinity Fc receptor, FcgammaRIIa (CD32) has been identified and its structure solved by NMR. Linear (7-mer and 12-mer) and disulphide-constrained (7-mer) phage display peptide libraries were pan
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1774:1208-1212
Binding of the Cdc25c-T48 ligand to PinA from Aspergillus nidulans has been characterised by the identification of 15N and 1H resonances from 1H-15N HSQC NMR titration experiments using previous backbone assignments. It is shown that the binding site
Publikováno v:
Carbohydrate Research. 341:1743-1747
A simple gram-scale synthesis of uridine diphospho(13C6)glucose is presented from D-(13C6)glucose. The critical step uses a 1H-tetrazole-catalyzed coupling of 2,3,4,6-tetra-O-acetyl-alpha-D-glucopyranosyl-1-phosphate and UMP-morpholidate. The uridine
Autor:
Frances Separovic, Robert T. C. Brownlee, Chai Ann Ng, Mikael Bergdahl, Robert P. Metzger, Jason Dang
Publikováno v:
European Biophysics Journal. 34:383-388
The antibiotic virginiamycin is a combination of two molecules, virginiamycin M1 (VM1) and virginiamycin S1 (VS1) or analogues, which function synergistically by binding to bacterial ribosomes and inhibiting bacterial protein synthesis. Both VM1 and
Publikováno v:
Chemical Reviews. 104:5823-5846
Publikováno v:
Molecular Simulation. 28:827-843
NMR spectroscopy techniques have been used to determine the conformation of DG35-VIII in DMSO, acetone, and methanol. COSY and Heteronuclear Correlation experiments were used to confirm the proton spectral assignments. NOESY experiments were used to
Autor:
Suzanne M. Cutts, Robert T. C. Brownlee, Benny J. Evison, Elizabeth A. Ankers, Don R. Phillips
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(24)
A novel derivative of the anti-tumor agent N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) was prepared by reduction of 9-oxoacridan-4-carboxylic acid to acridine-4-carboxylic acid with subsequent conversion to N-(4-aminobutyl)acridine-4-carb