Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Robert T Williams"'
Publikováno v:
Molecular Metabolism, Vol 33, Iss , Pp 67-82 (2020)
Background: Cancer cells rewire their metabolism to meet the energetic and biosynthetic demands of their high proliferation rates and environment. Metabolic reprogramming of cancer cells may result in strong dependencies on nutrients that could be ex
Externí odkaz:
https://doaj.org/article/4358c7e12b7244aba982f63eb9623697
Autor:
Jan Philipp Bewersdorf, Smith Giri, Rong Wang, Robert T. Williams, Martin S. Tallman, Amer M. Zeidan, Maximilian Stahl
Publikováno v:
Haematologica, Vol 105, Iss 11 (2020)
Externí odkaz:
https://doaj.org/article/e13a895f47c24604a67d539737e3b351
Autor:
Maximilian Stahl, Raajit K. Rampal, Nikolai A. Podoltsev, Jan Philipp Bewersdorf, Robert T. Williams, Martin S. Tallman, Amer M. Zeidan, Rong Wang, Smith Giri
Publikováno v:
Clin Lymphoma Myeloma Leuk
Background Myelofibrosis (MF) is a Philadelphia chromosome–negative myeloproliferative neoplasm characterized by progressive bone marrow failure, increased risk of progression to acute myeloid leukemia, and constitutional symptoms. For over 3 decad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24b7ac59d5a523bb90493bbfe3d8e162
https://doi.org/10.1016/j.clml.2020.05.018
https://doi.org/10.1016/j.clml.2020.05.018
Autor:
Rong Wang, Jan Philipp Bewersdorf, Robert T. Williams, Amer M. Zeidan, Martin S. Tallman, Nikolai A. Podoltsev, Raajit K. Rampal, Smith Giri, Maximilian Stahl
Publikováno v:
Leukemia
Data on the efficacy and safety of interferon (IFN)-α for the treatment of essential thrombocythemia (ET) and polycythemia vera (PV) are inconsistent. We conducted a systematic review and meta-analysis and searched MEDLINE and EMBASE via Ovid, Scopu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae81eead41023badb60911e4432d2a20
https://doi.org/10.1038/s41375-020-01020-4
https://doi.org/10.1038/s41375-020-01020-4
Publikováno v:
Leukemialymphoma. 63(3)
Cancer cells reprogram their metabolism to maintain sustained proliferation, which creates unique metabolic dependencies between malignant and healthy cells that can be exploited for therapy. In acute myeloid leukemia (AML), mitochondrial inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b827e2e6193974758b9800514cbb20a4
https://pubmed.ncbi.nlm.nih.gov/34704521
https://pubmed.ncbi.nlm.nih.gov/34704521
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 33, Iss, Pp 67-82 (2020)
Molecular Metabolism, Vol 33, Iss, Pp 67-82 (2020)
Background: Cancer cells rewire their metabolism to meet the energetic and biosynthetic demands of their high proliferation rates and environment. Metabolic reprogramming of cancer cells may result in strong dependencies on nutrients that could be ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bdd640739f645ae96c1a031dd74cdac
http://europepmc.org/articles/PMC7056928
http://europepmc.org/articles/PMC7056928
Autor:
Naz Ekizoglu, Rohiverth Guarecuco, Lou Baudrier, Henrik Molina, Maria C. Passarelli, Javier Garcia-Bermudez, Justine Fidelin, Robert T. Williams, Mert Mestanoglu, Hanan Alwaseem, Konnor La, Kıvanç Birsoy, Bety Rostandy
Publikováno v:
Science Advances
Plasma thiamine concentrations affect l-asparaginase sensitivity of leukemia cells deficient for thiamine uptake.
Tumor environment influences anticancer therapy response but which extracellular nutrients affect drug sensitivity is largely unkno
Tumor environment influences anticancer therapy response but which extracellular nutrients affect drug sensitivity is largely unkno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da695346be1fce5baa44113030c21bd9
https://doi.org/10.1126/sciadv.abc7120
https://doi.org/10.1126/sciadv.abc7120
Autor:
Thomas L. Carroll, Sohail Malik, Rohiverth Guarecuco, Robert T. Williams, Javier Garcia-Bermudez, Robert G. Roeder, Jason Cantor, Xiphias Ge Zhu, Benjamin Prizer, Omar Abdel-Wahab, Swarna Jeewajee, Bryce W. Carey, Lou Baudrier, Maria C. Passarelli, Leah Gates, Douglas Barrows, Konnor La, Kıvanç Birsoy, Henrik Molina, C. David Allis
Publikováno v:
Cell Metab
Activating transcription factor 4 (ATF4) is a master transcriptional regulator of the integrated stress response (ISR) that enables cell survival under nutrient stress. The mechanisms by which ATF4 couples metabolic stresses to specific transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04346d529b0911765de8c55a3dc13158
https://pubmed.ncbi.nlm.nih.gov/32268116
https://pubmed.ncbi.nlm.nih.gov/32268116
Autor:
Matthias Stephan, Monique J. Kauke, Eric F. Zhu, Alessandro Angelini, Louis M. Weiner, Robert T. Williams, Kelly D. Moynihan, Jacob S. Kim, Byron Hua Kwan, Darrell J. Irvine, Michael B. Yaffe, K. Dane Wittrup, Glenn Dranoff, Rishi Surana, Martin C. Mihm, Cary F. Opel, Shuning A. Gai
Publikováno v:
PMC
Cancer immunotherapies under development have generally focused on either stimulating T cell immunity or driving antibody-directed effector functions of the innate immune system such as antibody-dependent cell-mediated cytotoxicity (ADCC). We find th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5eb98010bffc6a3a73f5f994e1e74f4
Autor:
Erik L. Miller, Simon M. G. Braun, Gerald R. Crabtree, Emma J. Chory, Cigall Kadoch, Robert T Williams, Joseph P Calarco, Christopher M. Weber, John L. Pulice
Publikováno v:
Nature Genetics, Vol. 49, No 2 (2017) pp. 213-222
Nature genetics
Nature genetics
The opposition between Polycomb repressive complexes (PRCs) and BAF (mSWI/SNF) complexes has a critical role in both development and disease. Mutations in the genes encoding BAF subunits contribute to more than 20% of human malignancies, yet the unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d75515730584b4cfcebecce938e942
https://archive-ouverte.unige.ch/unige:154520
https://archive-ouverte.unige.ch/unige:154520
