Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Robert T Jacobs"'
Autor:
Alexandra Ehrens, Christopher S Lunde, Robert T Jacobs, Dominique Struever, Marianne Koschel, Stefan J Frohberger, Franziska Lenz, Martina Fendler, Joseph D Turner, Stephen A Ward, Mark J Taylor, Yvonne R Freund, Rianna Stefanakis, Eric Easom, Xianfeng Li, Jacob J Plattner, Achim Hoerauf, Marc P Hübner
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 1, p e0007957 (2020)
The elimination of filarial diseases such as onchocerciasis and lymphatic filariasis is hampered by the lack of a macrofilaricidal-adult worm killing-drug. In the present study, we tested the in vivo efficacy of AN11251, a boron-pleuromutilin that ta
Externí odkaz:
https://doaj.org/article/dec6d4c0192a4b7f912f2690a17c0fac
Autor:
Ning Zhang, Martin Zoltner, Ka-Fai Leung, Paul Scullion, Sebastian Hutchinson, Ricardo C Del Pino, Isabel M Vincent, Yong-Kang Zhang, Yvonne R Freund, Michael R K Alley, Robert T Jacobs, Kevin D Read, Michael P Barrett, David Horn, Mark C Field
Publikováno v:
PLoS Pathogens, Vol 14, Iss 2, p e1006850 (2018)
Recent development of benzoxaborole-based chemistry gave rise to a collection of compounds with great potential in targeting diverse infectious diseases, including human African Trypanosomiasis (HAT), a devastating neglected tropical disease. However
Externí odkaz:
https://doaj.org/article/15b9266be10f461686b0efc0aad70326
Autor:
Robert T Jacobs, Bakela Nare, Stephen A Wring, Matthew D Orr, Daitao Chen, Jessica M Sligar, Matthew X Jenks, Robert A Noe, Tana S Bowling, Luke T Mercer, Cindy Rewerts, Eric Gaukel, Jennifer Owens, Robin Parham, Ryan Randolph, Beth Beaudet, Cyrus J Bacchi, Nigel Yarlett, Jacob J Plattner, Yvonne Freund, Charles Ding, Tsutomu Akama, Y-K Zhang, Reto Brun, Marcel Kaiser, Ivan Scandale, Robert Don
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 5, Iss 6, p e1151 (2011)
BACKGROUND: Human African trypanosomiasis (HAT) is an important public health problem in sub-Saharan Africa, affecting hundreds of thousands of individuals. An urgent need exists for the discovery and development of new, safe, and effective drugs to
Externí odkaz:
https://doaj.org/article/63cd3700496b42e79618890a16e02bc3
Autor:
Christopher S. Lunde, Erin E. Stebbins, Rajiv S. Jumani, Md Mahmudul Hasan, Peter Miller, John Barlow, Yvonne R. Freund, Pamela Berry, Rianna Stefanakis, Jiri Gut, Philip J. Rosenthal, Melissa S. Love, Case W. McNamara, Eric Easom, Jacob J. Plattner, Robert T. Jacobs, Christopher D. Huston
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Cryptosporidium infection can cause severe diarrhea with limited treatment options available. Here, Lunde et al. perform a drug repositioning screen with a library of benzoxaboroles and identify AN7973 as potent inhibitor of intracellular parasite de
Externí odkaz:
https://doaj.org/article/9ffc28868e0b404a868e8f4e98e9bbf7
Autor:
Stéphanie Braillard, Jason Speake, Sandra Carvalho, Yvonne Freund, Gavin A. Whitlock, Guy Caljon, Bakela Nare, Paul Alan Glossop, Victoriano Corpas-López, Fabio Zuccotto, Louis Maes, Davide Bello, Ian H. Gilbert, Susan Wyllie, Bharathi Pandi, Iva Lukac, Robert T. Jacobs, Magali Van den Kerkhof, Vanessa Yardley, Charles E. Mowbray, Richard J. Wall, Stephen Patterson
Publikováno v:
Journal of Medicinal Chemistry
Journal of medicinal chemistry
Journal of medicinal chemistry
Visceral leishmaniasis (VL) is a parasitic disease endemic across multiple regions of the world and is fatal if untreated. Current therapies are unsuitable, and there is an urgent need for safe, short-course, and low-cost oral treatments to combat th
Autor:
Katherine M. Liebman, Aaron Nilsen, Rolf W. Winter, Michael K. Riscoe, Lisa Frueh, David R. Stuart, Robert T. Jacobs, J. Stone Doggett, Rory T. Gallagher, Haihong Jin, Sovitj Pou, Rozalia Dodean
Publikováno v:
Organic Process Research & Development. 25:1841-1852
Autor:
Michelle M Butler, Samanthi L. Waidyarachchi, Jinfeng Shao, Son T. Nguyen, Xiaoyuan Ding, Steven C. Cardinale, Lucas R. Morin, Steven M. Kwasny, Mai Ito, Jeanine Gezelle, Maria B. Jiminez-Diaz, Inigo Angulo-Barturen, Robert T. Jacobs, Jeremy N. Burrows, Zachary D. Aron, Terry L. Bowlin, Sanjay A. Desai
Publikováno v:
Mol Pharmacol
Human and animal malaria parasites increase their host erythrocyte permeability to a broad range of solutes as mediated by parasite-associated ion channels. Molecular and pharmacological studies have implicated an essential role in parasite nutrient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd2cfbfaccb951c5eceaee13a146c87
https://europepmc.org/articles/PMC9450958/
https://europepmc.org/articles/PMC9450958/
Autor:
Robert T. Jacobs, Rianna Stefanakis, Nancy Tricoche, Eric E. Easom, Yvonne Freund, Kee Chong Lim, James H. McKerrow, David S. Carter, Christina A. Bulman, Brian M. Suzuki, Christopher S. Lunde, Pamela Berry, Judy A. Sakanari, Jacob J. Plattner, Chelsea Fischer, Sara Lustigman, Tsutomu Akama, Fernando Rock
Publikováno v:
ACS Infectious Diseases
The optimization of a series of benzimidazole–benzoxaborole hybrid molecules linked via a ketone that exhibit good activity against Onchocerca volvulus, a filarial nematode responsible for the disease onchocerciasis, also known as river blindness,
Autor:
Angel M. Padilla, Wei Wang, Tsutomu Akama, David S. Carter, Eric Easom, Yvonne Freund, Jason S. Halladay, Yang Liu, Sarah A. Hamer, Carolyn L. Hodo, Gregory K. Wilkerson, Dylan Orr, Brooke White, Arlene George, Huifeng Shen, Yiru Jin, Michael Zhuo Wang, Susanna Tse, Robert T. Jacobs, Rick L. Tarleton
Publikováno v:
Nature microbiology. 7(10)
Trypanosoma cruzi, the agent of Chagas disease, probably infects tens of millions of people, primarily in Latin America, causing morbidity and mortality. The options for treatment and prevention of Chagas disease are limited and underutilized. Here w
Autor:
Rianna Stefanakis, Eric E. Easom, Jacob J. Plattner, Yvonne Freund, Erin E. Stebbins, Melissa S. Love, Pamela Berry, Jiri Gut, Christopher D. Huston, Rajiv S. Jumani, Case W. McNamara, Philip J. Rosenthal, Peter J. Miller, Christopher S. Lunde, Robert T. Jacobs, John W. Barlow, Mahmudul Hasan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications
Nature Communications
Cryptosporidiosis is a leading cause of life-threatening diarrhea in young children and causes chronic diarrhea in AIDS patients, but the only approved treatment is ineffective in malnourished children and immunocompromised people. We here use a drug