Mathematical Modeling Highlights the Complex Role of AKT in TRAIL-Induced Apoptosis of Colorectal Carcinoma Cells

Autor: Matthew W. Anderson, Joanna J. Moss, Robert Szalai, Jon D. Lane

Publikováno v: iScience, Vol 12, Iss , Pp 182-193 (2019)

Summary: Protein kinase B/AKT is a highly connected protein involved in a range of signaling pathways. Although it is known to regulate several proteins in the apoptotic pathway, its system-level effects remain poorly understood. We investigated the

Externí odkaz: https://doaj.org/article/a583d069791f45bc9c8ebf5355570a19

Uncountably many cases of Filippov's sewed focus

Autor: Paul Glendinning, S. John Hogan, Martin Homer, Mike R. Jeffrey, Robert Szalai

Publikováno v: Glendinning, P, John hogan, S, Homer, M, Jeffrey, M R & Szalai, R 2023, ' Uncountably Many Cases of Filippov’s Sewed Focus ', Journal of Nonlinear Science, vol. 33, no. 4, 52 . https://doi.org/10.1007/s00332-023-09910-4

The sewed focus is one of the singularities of planar piecewise smooth dynamical systems. Defined by Filippov in his book 'Differential Equations with Discontinuous Righthand Sides' (Kluwer, 1988), it consists of two invisible tangencies either side

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc0bfeba6579f3798622b47c4e17d17

Nonlinear model identification and spectral submanifolds for multi-degree-of-freedom mechanical vibrations

Autor: Robert Szalai, David A. Ehrhardt, George Haller

Publikováno v: Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, 473 (2202)
Proceedings. Mathematical, Physical, and Engineering Sciences
Szalai, R, Ehrhardt, D & Haller, G 2017, ' Nonlinear model identification and spectral submanifolds for multi-degree-of-freedom mechanical vibrations ', Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, vol. 473, no. 2202, 20160759 . https://doi.org/10.1098/rspa.2016.0759

In a nonlinear oscillatory system, spectral submanifolds (SSMs) are the smoothest invariant manifolds tangent to linear modal subspaces of an equilibrium. Amplitude–frequency plots of the dynamics on SSMs provide the classic backbone curves sought

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::369b49b966834bf54316843decdf6f5a
https://hdl.handle.net/20.500.11850/234370

Substructurability:The effect of interface location on a real-time dynamic substructuring test

Autor: Nándor Terkovics, Bernd Krauskopf, Robert Szalai, Simon A Neild, Mark H Lowenberg

Publikováno v: Terkovics, N, Neild, S A, Lowenberg, M, Szalai, R & Krauskopf, B 2016, ' Substructurability : The effect of interface location on a real-time dynamic substructuring test ', Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, vol. 472, no. 2192, 20160433 . https://doi.org/10.1098/rspa.2016.0433
Proceedings. Mathematical, Physical, and Engineering Sciences / The Royal Society

A full-scale experimental test for large and complex structures is not always achievable. This can be due to many reasons, the most prominent one being the size limitations of the test. Real-time dynamic substructuring is a hybrid testing method wher

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b256635b05f66f4d9cfc944b49326c0
https://research-information.bris.ac.uk/ws/files/83659437/20160433.full.pdf

On time-delayed and feed-forward transmission line models of the cochlea

Autor: Bastian Epp, Martin Homer, Robert Szalai, Alan R Champneys

Publikováno v: Journal of Mechanics of Materials and Structures. 6:557-568

The mammalian cochlea is a remarkable organ that is able to provide up to 60dB amplification of low amplitude sound with sharp tuning. It has been proposed that in order qualitatively to explain experimental data, models of the basilar membrane imped

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e778599f7a67c10a5dd303e6023e7827
https://doi.org/10.2140/jomms.2011.6.557