Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Robert Strome"'
Autor:
Li Ma, Robert C.C. Mercer, Robert Strome, Gerold Schmitt-Ulms, Serene Wohlgemuth, Michael B. Coulthart, Jack H. Jhamandas, David Westaway, Neil R. Cashman, Joel C. Watts, Jing Yang
Publikováno v:
Journal of Biological Chemistry. 288:37241-37255
Widely expressed in the adult central nervous system, the cellular prion protein (PrP(C)) is implicated in a variety of processes, including neuronal excitability. Dipeptidyl aminopeptidase-like protein 6 (DPP6) was first identified as a PrP(C) inter
Autor:
S D’Amelio, Christopher Janus, George A. Carlson, Paul E. Fraser, O Amitay, John C. Roder, Robert Strome, P H St George Hyslop, David Westaway, M A Chishti
Publikováno v:
Neurobiology of Aging. 21:541-549
Dominant mutations in the Presenilin 1 gene are linked to an aggressive, early-onset form of familial Alzheimer's Disease (FAD). Spatial memory of transgenic (Tg) mice expressing either mutant (lines Tg(M146L)1, Tg(M146L)76, Tg(L286V)198) or wild typ
Publikováno v:
The EMBO Journal. 17:2308-2318
The Drosophila homeodomain-containing protein Fushi tarazu (Ftz) is expressed sequentially in the embryo, first in alternate segments, then in specific neuroblasts and neurons in the central nervous system, and finally in parts of the gut. During the
Publikováno v:
Neuroscience Letters. 234:11-14
PrP(C), the cellular isoform of the prion protein (PrP) serves as a precursor to abnormal PrP isoforms which accumulate in diseases such as scrapie in sheep, and Creutzfeldt-Jakob disease in humans. Since prions can replicate in photoreceptors we sur
Autor:
Weiming Xia, Ivan Lieberburg, Peter St. George Hyslop, Dale Schenk, G. Levesque, Thekla S. Diehl, Peter Seubert, Dennis J. Selkoe, Paul E. Fraser, Billie J. Perry, Dora Kholodenko, Kelly Johnson-Wood, Robert Strome, Johanna M. Rommens, Soyeon Kim, Hong Yao, Angela Davis, Ruth Motter, Martin Citron, R. Sherrington, George A. Carlson, David Westaway, Michael K. Lee
Publikováno v:
Nature Medicine. 3:67-72
The mechanism by which mutations in the presenilin (PS) genes cause the most aggressive form of early-onset Alzheimer's disease (AD) is unknown, but fibroblasts from mutation carriers secrete increased levels of the amyloidogenic A beta 42 peptide, t
Autor:
Robert Strome, Hansen Wang, Lili-Naz Hazrati, George A. Carlson, Hairu Huo, Sepehr Ehsani, Ekaterina Rogaeva, Gerold Schmitt-Ulms, Kelvin So, Cosmin L. Pocanschi, William S. Trimble, Mohadeseh Mehrabian, David Westaway, William Reginold, Christine Sato, Hezhen Ren, Ashkan Salehzadeh
Publikováno v:
Journal of molecular biology. 422(4)
We recently documented the co-purification of members of the LIV-1 subfamily of ZIP (Zrt-, Irt-like Protein) zinc transporters (LZTs) with the cellular prion protein (PrP(C)) and, subsequently, established that the prion gene family descended from an
Autor:
Christine Sato, Danielle Moreno, Janice Robertson, Juan M. Bilbao, Robert Strome, Ekaterina Rogaeva, Lorne Zinman, Shinya Tokuhiro, Lili-Naz Hazrati, Ian R. A. Mackenzie
Publikováno v:
Neurobiology of aging. 32(3)
It has been shown that mutations in the Fused in Sarcoma gene (FUS) could explain up to 5% of cases with familial amyotrophic lateral sclerosis (ALS). Our mutation analysis of FUS in a Canadian ALS patient of Chinese origin revealed an unusual novel
Autor:
Charlie Boone, David Westaway, Dilya Arslanova, Robert Strome, Matthew J. Mazzella, Peter Mastrangelo, Paul E. Fraser, Paul M. Mathews, Peter St George-Hyslop
Publikováno v:
Alzheimer's & Dementia. 2
Autor:
Céline Morissette, Patrick Horne, George A. Carlson, Sherry Turner, Christopher Janus, Noah Zuker, Peter St George-Hyslop, David Westaway, Jacqueline Pearson, Paul E. Fraser, Amie L. Phinney, Dun-Shen Yang, Gianluca Lozza, Francine Gervais, Janet French, Suzanne Kunicki, Robert Strome, Mariagrazia Grilli, Catherine Bergeron, M. Azhar Chishti, Julie Paquette, James E. Loukides
Publikováno v:
The Journal of biological chemistry. 276(24)
We have created early-onset transgenic (Tg) models by exploiting the synergistic effects of familial Alzheimer's disease mutations on amyloid beta-peptide (Abeta) biogenesis. TgCRND8 mice encode a double mutant form of amyloid precursor protein 695 (
Autor:
Catherine Bergeron, R. Sherrington, George A. Carlson, P. St. George-Hyslop, David Westaway, G. Levesque, C. Weaver, John C. Roder, Sam Gandy, Paul E. Fraser, Robert Strome, Johanna M. Rommens, Hong Yao, D. Shenk, B. Perry, Peter Davies, A. Davies
Publikováno v:
Prions and Brain Diseases in Animals and Humans ISBN: 9781489918987
In contrast to rare mutations in the amyloid presursor protein (APP) gene, missense mutations in the presenilin 1 (PS1) and presenilin 2 (PS2) genes, on chromosomes 14 and 1 respectively, are the most common causes of early-onset familial Alzheimer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31cedc08993ae95e005bfc81573ee17e
https://doi.org/10.1007/978-1-4899-1896-3_17
https://doi.org/10.1007/978-1-4899-1896-3_17