Výsledky vyhledávání - "Robert Snoek"

Data from In vivo Knockdown of the Androgen Receptor Results in Growth Inhibition and Regression of Well-Established, Castration-Resistant Prostate Tumors

Autor: Paul S. Rennie, Martin E. Gleave, Colleen C. Nelson, Ladan Fazli, Erica Chan Wong, Charmaine A. Wong, Latif A. Wafa, Katia Margiotti, Helen Cheng, Robert Snoek

Purpose: Progression to the castration-resistant state is the incurable and lethal end stage of prostate cancer, and there is strong evidence that androgen receptor (AR) still plays a central role in this process. We hypothesize that knocking down AR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f45dfa421f175bcf5d1edf53473edbf
https://doi.org/10.1158/1078-0432.c.6516819

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Cyclin G-associated kinase: A novel androgen receptor-interacting transcriptional coactivator that is overexpressed in hormone refractory prostate cancer

Autor: Latif A. Wafa, Mira R. Ray, Martin E. Gleave, Helen Cheng, Ladan Fazli, Paul S. Rennie, Robert Snoek

Publikováno v: International Journal of Cancer. 118:1108-1119

The androgen receptor (AR), a steroid receptor family member, is a ligand-dependent transcription factor that has an integral role in normal prostate development. Alterations in AR-mediated activity can result in abnormal gene expression, dysregulate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b16ec5867228404611940c168fcbb518
https://doi.org/10.1002/ijc.21469

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Alkyloxyphenyl Furano Pyrimidines as Potent and Selective Anti-VZV Agents with Enhanced Water Solubility

Autor: Robert Snoek, Christopher McGuigan, Erik De Clercq, Sally Blewett, Dario Siccardi, Jonathan T. Erichsen, Jan Balzarini, Graciela Andrei

Publikováno v: Antiviral Chemistry and Chemotherapy. 13:91-99

We have previously reported bicyclic furanopyrimidines as potent and selective inhibitors of varicella zoster virus (VZV) with subnanomolar activity for p-alkylphenyl substituted analogues. These compounds are highly lipophilic and of limited water s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcb066d0cc3acff43785ef01ed61d9fc
https://doi.org/10.1177/095632020201300203

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Differential transactivation by the androgen receptor in prostate cancer cells

Autor: Martin Gleave, Nicholas Bruchovsky, Robert J. Matusik, Robert Snoek, Paul S. Rennie, Susan Kasper, Nasrin R. Mawji, Naohide Sato

Publikováno v: The Prostate. 36:256-263

BACKGROUND The purpose of this study was to determine the contribution of different transactivating regions of the androgen receptor (AR) to the induction of androgen-regulated promoters in poorly (PC3 cells) and well-differentiated (LNCaP cells) pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94609ba2481aa04b970070d039771362
https://doi.org/10.1002/(sici)1097-0045(19980901)36:4<256::aid-pros7>3.0.co

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Induction of cell-free, in vitro transcription by recombinant androgen receptor peptides

Autor: Paul S. Rennie, Susan Kasper, Robert J. Matusik, Nicholas Bruchovsky, Robert Snoek

Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology. 59:243-250

An in vitro, cell-free transcription system, based on prostate-derived transcriptional machinery and very powerful androgen response elements (AREs), has been developed. Multiple (p(ARR3)LovTATA) AREs from the androgen-regulated probasin gene were li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61d31009aa71f0fc21bdb83cf3f8bdd8
https://doi.org/10.1016/s0960-0760(96)00116-1

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Cyclopentene carbocyclic nucleosides related to the antitumor nucleoside clitocine and their conversion to 8-Aza-neplanocin analogues. Synthesis and antiviral activity

Autor: Benjamin B. Lim, John S. Driscoll, Robert Snoek, Victor E. Marquez, Graciela Andrei, Jan Balzarini, Erick De Clercq, Satoru Ikeda

Publikováno v: Journal of Heterocyclic Chemistry. 30:1393-1398

Synthesis of the cyclopentene carbocyclic analogue of the naturally occurring nucleoside clitocine (1) is reported. Starting with racemic cyclopentenylamine (10), the heterocyclic moieties of the clitocine analogue 4 and related 1,6-dihydro-6-oxo, 5,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a6879048864a33b54d4a9651606c52b4
https://doi.org/10.1002/jhet.5570300536

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TAF1 differentially enhances androgen receptor transcriptional activity via its N-terminal kinase and ubiquitin-activating and -conjugating domains

Autor: Amina Zoubeidi, Robert Snoek, Helen Cheng, Peyman Tavassoli, Paul S. Rennie, Latif A. Wafa, Ladan Fazli, Martin E. Gleave

Publikováno v: Molecular endocrinology (Baltimore, Md.). 24(4)

Aberrant expression of androgen receptor (AR) coregulators has been linked to progression of prostate cancers to castration resistance. Using the repressed transactivator yeast two-hybrid system, we found that TATA binding protein-associated factor 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d8b0350ec90d2805c8101ac27a5c94
https://pubmed.ncbi.nlm.nih.gov/20181722

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Androgen Receptor Coregulators and Their Role in Prostate Cancer

Autor: Paul S. Rennie, Robert Snoek, Latif A. Wafa

Publikováno v: Androgen Action in Prostate Cancer ISBN: 9780387691770

The limiting factor in the survival of a patient with prostate cancer is the rate of progression to the noncurable androgen-independent (AI) stage of disease. The androgen receptor (AR) is a critical regulator of prostate cancer development and is in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d969087e9a0b663470eb50555778b33
https://doi.org/10.1007/978-0-387-69179-4_15

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