Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Robert Sjoholm"'
Autor:
Greg Voss, Robert Sjoholm, Christine Olney, Andrew H. Hansen, John M Looft, Stuart R. Fairhurst, Gary D Goldish, Jason S. Egginton, Clifford A Dellamano
Publikováno v:
J Spinal Cord Med
CONTEXT/OBJECTIVE: There are no wheelchair products designed to allow users to dynamically control trunk posture to both significantly improve functional reach and provide pressure relief during forward lean. This pilot study sought to (1) gather sta
Autor:
Megan Lee, Amanda Ferguson, Shuo Wang, Balaji Babu, W. David Wilson, John A. Hartley, Toni Rice, Robert Sjoholm, Moses Lee, Hilary Mackay, Konstantinos Kiakos, Pravin C. Patil, Shicai Lin, Samuel Tzou, Joseph P. Ramos, Adam J. Plaunt, Sameer Chavda
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:3907-3918
Orthogonally positioned diamino/dicationic polyamides (PAs) have good water solubility and enhanced binding affinity, whilst retaining DNA minor groove and sequence specificity compared to their monoamino/monocationic counterparts. The synthesis and
Autor:
Toni Rice, Samuel Tzou, Mary Pressler, Robert Sjoholm, Moses Lee, Ross Ogilvie, Hilary Mackay, Adam J. Plaunt, Michael D Seymour, Vijay Satam, Olivia Sweat, Hao Shen, Shannon Alger, Balaji Babu, Kimberly A. Brien
Publikováno v:
hc. 18:79-85
Covalently linked pyrrole (Py)- and imidazole (Im)-containing H-pin polyamides bind in the minor groove of specific DNA sequences with high affinity. The synthesis of 1,2,3-triazole-linked and heterodimeric H-pin polyamides 13a,b formed from the Huis
Autor:
Susan L. Mooberry, Robert Sjoholm, Cara Westbrook, Moses Lee, Matthias Zeller, Vijay Satam, Olivia Brockway, Balaji Babu, Megan Lee, Armaan Dandavati, Samuel Tzou
Publikováno v:
European Journal of Medicinal Chemistry. 46:3099-3104
Thirteen methylpyrazoline analogs (1a-m) of combretastatin A-4 (CA-4, 2) were synthesized. The trans-geometry of the two substituted phenyl moieties was ascertained by a single crystal X-ray diffraction study of compound 1d. The cytotoxicities of the
Autor:
Sameer Chavda, Susan L. Mooberry, Alexis Nickols, Olivia Brockway, Cara Westbrook, Moses Lee, Balaji Babu, Raymond Strobel, Gregory S. Fraley, Lauren Lee, Adam M. Siegfried, William T. Pennington, Dereje Desta, Robert Sjoholm, Konstantinos Kiakos, Samuel Tzou, Megan Lee, John A. Hartley, Rachel M. Hartley
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:2359-2367
The combretastatins have received significant attention because of their simple chemical structures, excellent antitumor efficacy and novel antivascular mechanisms of action. Herein, we report the synthesis of 20 novel acetyl analogs of CA-4 (1), syn
Autor:
Gregory S. Fraley, Rachel M. Hartley, Susan L. Mooberry, Robert Sjoholm, Balaji Babu, Cara Westbrook, Alexis Nickols, Samuel Tzou, Sameer Chavda, Olivia Brockway, Armaan Dandavati, Megan Lee, Vijay Satam, Moses Lee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2087-2091
Thirteen hydroxyethyl- analogs of combretastatin A-4 (CA-4) that contain the 1-(1′-hydroxyethyl)-1-(3″,4″,5″-trimethoxyphenyl)-2-(substituted phenyl)ethene framework were synthesized. Molecular modeling studies at the DFT level showed that co
Autor:
Lauren Lee, Aaron A. Best, Dereje Desta, Moses Lee, Christie Dewar, Sarah Canche, Stephanie K. Yanow, Megan Lee, Balaji Babu, Kristin Dittenhafer, Sameer Chavda, Robert Sjoholm
Publikováno v:
Medicinal Chemistry Research. 20:364-369
Eighteen 1,2,3,4-tetrahydro-2-thioxopyrimidine analogs (5a–j, 6a–e, and 7a–c) of combretastatin A-4 were synthesized with the objective of discovering compounds capable of controlling the growth of Trypanosoma lewisii, Leishmania tarantole, Pla
Autor:
Vijay, Satam, Balaji, Babu, Sameer, Chavda, Mia, Savagian, Robert, Sjoholm, Samuel, Tzou, Joseph, Ramos, Yang, Liu, Konstantinos, Kiakos, Shicai, Lin, W, David Wilson, John A, Hartley, Moses, Lee
Publikováno v:
Bioorganicmedicinal chemistry. 20(2)
Pyrrole- and imidazole-containing polyamides are widely investigated as DNA sequence selective binding agents that have potential use as gene control agents. The key challenges that must be overcome to realize this goal is the development of polyamid
Autor:
Chris R. Gissendanner, Jasper Van Kirk Thompson, Cynthia M. Bauerle, Kobie C. Gordon, Stephanie E. Trapani, Sarah C. R. Elgin, Ching-Chung Ko, Asma Latif, Caitlin E. Peirce, Jeremy S. Harmson, Elvis Nguyen, Jillian M. Walton, Siping He, Lauren L. Rodriguez, Jazmyn J. McCloud, Catherine J. Harmon, Angelica N. Willis, Melissa J. Fritz, Jessica A. Ruby, Michael P. Tokarz, Lisa Deng, Samantha T. Alford, Kathryn M. Sinclair, Victoria G. Hohenstein, Lauren Forbes, Erika F. Simms, Jessica M. Simmons, David A. Zaidins, Anthony T. Tubbs, Tyler M. Fox, Erica J. Puopolo, Garrett V. Hagopian, Hilary M. Whelan, Tina Q. Lu, Rachel Miller, Brandy M. Simpson, Emilie G. Weisser, Theresa W. Wong, Luke J. Peterson, Andrew C. Rose, Chelsea L. Cockburn, Tuajuanda C. Jordan, Daniel A. Russell, Yetta M. Robinson, Justin Z. Knutter, Tin-Yun Tang, Daryl Khaw, Ian Winsten Campbell, Stephen B. Taylor, Arrykka S. Jackson, Zein Al-Atrache, Amanda R. Schott, Samantha C. Wendler, John R. Warner, Sequoia I. Leuba, Steven G. Cresawn, J. Bradley Segal, Hannah S. Wirtshafter, Margaret S. Saha, Christine A. Boyer, Melina Y. Zúniga, Lucia P. Barker, Tamsen Polley, Marcella L. Erb, Anjali Menon, Victoria A. Bradley, Amanda J. Barber, Charles A. Bowman, Kaitlin E. Healy, Molly J. McDonough, Kaylee M. Nicholson, A. Javier Lopez, Andrew A. S. Ang, Erica M. Shepard, Leila Haghighat, Matthew B. Alfano, Manuel Ares, Kathryn Sheldon, Murray A. Katelyn, Alexander G. Anderson, Jeffrey D. Rubin, Larisa A. Kerrigan, Lisa Alexander, Krysta R. Guiney-Olsen, Deborah Jacobs-Sera, Junghee Kim, Rebecca Goldstein, Clark L. Straub, Lianne B. Cohen, Anne Georges, Erin N. Hildebrandt, Angela E. Engelsen, Bridget G. Guiza, Russell D. Green, Paul G. Jasinto, Allison M. Perz, Turi A. Alcoser, Laura Z. Filliger, H. S. Rabinowitz, Christopher D. Shaffer, Kathleen Weston-Hafer, William D. Barshop, Blaire C. Spaulding, Andrew J. Medenbach, Joseph Stukey, Michael J. Resiss, Samuel E. Harvey, Aaron A. Best, Nichols E. Amy, Kevin J. He, Erica C. Jansen, Danielle H. Wang, Katrina Nguyen, Katherine Belfield, Christine E. Schnitzler, Seegren V. Philip, Ian M. Bayles, Belle E. V. English, Graham F. Hatfull, Victor Mac, Barbara J. Taylor, Kathryn E. Loesser-Casey, Ingrid J. Slette, Nathan A. Holz, Rachel E. Pferdehirt, Emilie T. Nguyen, Nicholas Lowery, Agustin Borjon, Bo Zhang, Gail V. Larkin, Lynn O. Lewis, Ellen R. Higinbotham, Kevin W. Bradley, Patrick Ng, Brandon C. Yee, Kurt E. Williamson, Anne M. Campbell, Welkin H. Pope, Roger W. Hendrix, Craig L. Peebles, Jonathan M. Barrett, Brandon K. Morgan, Ericka L. Hufford, Ann M. Findley, Kayla N. Busby, Jonathan W. Shepardson, Breyon R. Dixon, Joe Pogliano, Stephanie Guerra, Robert Sjoholm, Dale J. Schipper, Phillip Wu, Steven M. Caruso, Larissa K. Temple, Yun jeong Yang, Jason H. Ho, Kohana D. Leuba, Judith Savitskaya, Alyssa Carey, Peter M. Hynes, Jonathan W. Jarvik, Jonathan Tsay, Corwin N. Rhyan, Marie D. Anderson, Lyons M. Tatyana, Rebekah D. Chew, Jennifer R. Laroche, Jessica S. Kelsey, Jeffrey Corajod, Keshav Budwal, James Sandoz, Tomas Kasza, Alexander P. Troum, Lindsay A. Parnell, Crystal Estrada, Sahrish Ekram, Shannon Goff, Hannah Wang, Mark H. Forsyth, Lauren N. Broadway, Madav K. Shroff, Zindzi D. George, Dee R. Denver, Grant A. Hartzog, Kimberly R. Davis, Kit Pogliano, Isaac R. Masters, Trevor Sughrue, Courtney A. Long, Vincent J. Huang, Gina M. Hogan, Roberto Puertas Garcia
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16329 (2011)
PLoS ONE
PLoS ONE
Mycobacteriophages are viruses that infect mycobacterial hosts such as Mycobacterium smegmatis and Mycobacterium tuberculosis. All mycobacteriophages characterized to date are dsDNA tailed phages, and have either siphoviral or myoviral morphotypes. H
Autor:
Curtis Merrick, Sameer Chavda, Samuel Tzou, Kristen Dittenhafer, Moses Lee, Robert Sjoholm, Dereje Desta, Olivia Brockway, Balaji Babu, Kristy Wu, Emily Cordes
Publikováno v:
Heterocyclic Communications. 16