Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Robert Simler"'
Autor:
John H. A. Amery, Stefan Andreas Lange, Hill Malcolm Leithhead, Robert Simler, Leigh Dixon, Frank Gielen, Cinzia Gazziola, Doug P. Nesta, Jale Muslehiddinoglu, Kirsten Storch, Claudia Mueller, Jeremy D. Prail, Anna L. Watson
Publikováno v:
Nucleic Acid Therapeutics
The most common approach for the manufacture of oligonucleotides includes isolation of the active pharmaceutical ingredient (API) via lyophilization to provide a solid product, which is then dissolved to provide an aqueous formulation. It is well kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0aaafb3daa2f2511a77619b48c69f0a
https://doi.org/10.1089/nat.2020.0846
https://doi.org/10.1089/nat.2020.0846
Publikováno v:
Journal of Pharmaceutical Sciences. 101:4140-4154
There is little knowledge available on the mechanistic features of the protein aggregation pathway, which lead to subvisible particles (SVPs) (0.1–100 µm in size). Additionally, the relationship between soluble aggregates (SAs) (those that are les
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f34caba9210da4e5af48947b17e4a55c
https://doi.org/10.1002/jps.23299
https://doi.org/10.1002/jps.23299
Autor:
Martin Rides, Barry Kingston Derham, Bernardo Perez-Ramirez, Robert Simler, Jonathan D. Moore, Eleonora Cerasoli, Jan Jezek
Publikováno v:
Advanced Drug Delivery Reviews. 63:1107-1117
The use of monoclonal antibodies as therapeutic agents has been increasing steadily over the last decade for the treatment of various conditions. There is often a need to deliver a large dose of the protein, so there is a trend toward developing comm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c0b5f0ddf7859832b1a3314303748fb
https://doi.org/10.1016/j.addr.2011.09.008
https://doi.org/10.1016/j.addr.2011.09.008
Autor:
Paolo Mangiagalli, Thomas Spitznagel, Michael Rosario Defelippis, Andrew Weiskopf, Bernardo Perez-Ramirez, Hanns-Christian Mahler, Douglas P. Nesta, Atanas Koulov, Patrick Garidel, Robert Simler, Klaus Wuchner, Irene Cecchini, Patricia W. Cash, Vincent Corvari, Linda O. Narhi, Mara Rossi, Roland Schmidt, Shawn Cao, Tony Lubiniecki, Alla Polozova, Andrea Herre, Satish K. Singh, Nataliya Afonina
Publikováno v:
Biologicals : journal of the International Association of Biological Standardization. 43(6)
Measurement and characterization of subvisible particles (including proteinaceous and non-proteinaceous particulate matter) is an important aspect of the pharmaceutical development process for biotherapeutics. Health authorities have increased expect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b89c37a0d1aa6d59cdd007e49c1292dd
https://pubmed.ncbi.nlm.nih.gov/26324466
https://pubmed.ncbi.nlm.nih.gov/26324466
Publikováno v:
Quality by Design for Biopharmaceutical Drug Product Development ISBN: 9781493923151
A systematic work process has been defined that strengthens the critical interface between discovery research and formulation development for the early identification of suitable protein candidates to be moved into formulation development and assess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71c5dd2b0679881e19ee6a7da6bc77dc
https://doi.org/10.1007/978-1-4939-2316-8_6
https://doi.org/10.1007/978-1-4939-2316-8_6
Autor:
Irene Cecchini, Paolo Mangiagalli, Robert Simler, Hanns-Christian Mahler, Douglas P. Nesta, Patrick Garidel, Dean C. Ripple, Atanas Koulov, Mara Rossi, Bernardo Perez-Ramirez, Satish K. Singh, Thomas Spitznagel, Alla Polozova, Andrew Weiskopf, Nataliya Afonina, Linda O. Narhi, Andrea Herre, Roland Schmidt, Tony Lubiniecki, Vincent Corvari, Michael Rosario Defelippis, Klaus Wuchner
Publikováno v:
Journal of pharmaceutical sciences. 104(6)
Measurement and characterization of subvisible particles (defined here as those ranging in size from 2 to 100 μm), including proteinaceous and nonproteinaceous particles, is an important part of every stage of protein therapeutic development. The to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c6a430a97abb4eefc995724dcc7607c
https://pubmed.ncbi.nlm.nih.gov/25832583
https://pubmed.ncbi.nlm.nih.gov/25832583
Publikováno v:
Journal of Molecular Biology. 312:1121-1134
The folding mechanism of the dimeric Escherichia coli Trp repressor (TR) is a kinetically complex process that involves three distinguishable stages of development. Following the formation of a partially folded, monomeric ensemble of species, within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17ae487de02424c0696da80857ee08b7
https://doi.org/10.1006/jmbi.2001.4974
https://doi.org/10.1006/jmbi.2001.4974
Autor:
Robert Simler, Cindy F. Baulsir
Publikováno v:
Advanced Drug Delivery Reviews. 21:191-203
The history and use of mid-infrared fiber optics accessories as analytical tools is presented. The sensitivity and high throughput of Fourier transform infrared (FT-IR) spectrometers, combined with high optical efficiency mid-IR fiber optic materials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f107e2a84c8685a36cc2190cc927523
https://doi.org/10.1016/s0169-409x(96)00407-3
https://doi.org/10.1016/s0169-409x(96)00407-3
Publikováno v:
Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::089cfe415d8369c71604a682c1f51905
https://doi.org/10.1002/9780470595886.ch5
https://doi.org/10.1002/9780470595886.ch5
Publikováno v:
Journal of molecular biology. 363(1)
Enhanced structural insights into the folding energy landscape of the N-terminal dimerization domain of Escherichia coli tryptophan repressor, [2-66]2 TR, were obtained from a combined experimental and theoretical analysis of its equilibrium folding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a22c659bbf301809992b18e3073aa19
https://pubmed.ncbi.nlm.nih.gov/16956620
https://pubmed.ncbi.nlm.nih.gov/16956620