Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Robert Silber"'
Autor:
William J. Meurer, Florian F. Schmitzberger, Sharon Yeatts, Viswanathan Ramakrishnan, Benjamin Abella, Tom Aufderheide, William Barsan, Justin Benoit, Scott Berry, Joy Black, Nia Bozeman, Kristine Broglio, Jeremy Brown, Kimberly Brown, Noelle Carlozzi, Angela Caveney, Sung-Min Cho, Hangyul Chung-Esaki, Robert Clevenger, Robin Conwit, Richelle Cooper, Valentina Crudo, Mohamud Daya, Deneil Harney, Cindy Hsu, Nicholas J. Johnson, Imad Khan, Shaveta Khosla, Peyton Kline, Anna Kratz, Peter Kudenchuk, Roger J. Lewis, Chaitra Madiyal, Sara Meyer, Jarrod Mosier, Marwan Mouammar, Matthew Neth, Brian O’Neil, James Paxton, Sofia Perez, Sarah Perman, Cemal Sozener, Mickie Speers, Aimee Spiteri, Valerie Stevenson, Kavita Sunthankar, Joseph Tonna, Scott Youngquist, Romergryko Geocadin, Robert Silbergleit, ICECAP trial investigators
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-23 (2024)
Abstract Background Cardiac arrest is a common and devastating emergency of both the heart and brain. More than 380,000 patients suffer out-of-hospital cardiac arrest annually in the USA. Induced cooling of comatose patients markedly improved neurolo
Externí odkaz:
https://doaj.org/article/d175c8409ccf45f19bb469ca803b04d6
Autor:
Florian Schmitzberger, Jennifer Fowler, Cindy H. Hsu, Manjunath P. Pai, Robert W. Neumar, William J. Meurer, Robert Silbergleit
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 11, Pp n/a-n/a (2024)
Abstract Intranasal insulin is a putative neuroprotective therapy after cardiac arrest, but safety in humans at doses extrapolated from animal models is unknown. This phase I, open‐label adaptive dose‐escalation study explores the maximum tolerat
Externí odkaz:
https://doaj.org/article/188d9feac7fa4c02855c8b4898ab5471
Autor:
John F. McDyer, Mahzad Azimpouran, Valerie L. Durkalski-Mauldin, Robert G. Clevenger, Sharon D. Yeatts, Xutao Deng, William Barsan, Robert Silbergleit, Nahed El Kassar, Iulia Popescu, Dimiter Dimitrov, Wei Li, Emily J. Lyons, Sophia C. Lieber, Mars Stone, Frederick K. Korley, Clifton W. Callaway, Larry J. Dumont, Philip J. Norris, for the SIREN-C3PO Investigators
Publikováno v:
JCI Insight, Vol 8, Iss 8 (2023)
Multiple randomized, controlled clinical trials have yielded discordant results regarding the efficacy of convalescent plasma in outpatients, with some showing an approximately 2-fold reduction in risk and others showing no effect. We quantified bind
Externí odkaz:
https://doaj.org/article/7c19e4b03dd34452bc1b28ddfdf94cec
Autor:
David J. Adams, Robert Silber, Darrel P. Cohen, Monroe E. Wall, Mansukh C. Wani, James L. Flowers, Govindarajan Manikumar, O. Michael Colvin
Publikováno v:
Leukemia Research. 23:1061-1070
The topoisomerase I inhibitor camptothecin and its analogs have potent activity against a wide range of solid tumors and several hematologic malignancies. Previous studies with these compounds using the MTT metabolic inhibition assay have shown signi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d6edc14c0ed79986e7f067d047d1ccd
https://doi.org/10.1016/s0145-2126(99)00133-2
https://doi.org/10.1016/s0145-2126(99)00133-2
Autor:
Abhishek G. Sathe, Richard C. Brundage, Vijay Ivaturi, James C. Cloyd, James M. Chamberlain, Jordan J. Elm, Robert Silbergleit, Jaideep Kapur, Lisa D. Coles
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 4, Pp 1444-1451 (2021)
Abstract Estimating early exposure of drugs used for the treatment of emergent conditions is challenging because blood sampling to measure concentrations is difficult. The objective of this work was to evaluate predictive performance of two early con
Externí odkaz:
https://doaj.org/article/f8f4a9c3744f4a54a8df1d458a787d4f
Autor:
Elizabeth W. Newcomb, Laura Morse, John C. Drygas, Zoe Nakos Canellakis, Mathew Mani, Dan Costin, Carl Rosenberg, Robert Silber, Barbara A. Degar, Milan Potmesil
Publikováno v:
Blood. 84:3440-3446
Chemosensitivity of B lymphocytes, obtained from 65 patients with B- cell chronic lymphocytic leukemia (B-CLL), Rai stages 0 through IV, was determined using the MTT assay. The results were expressed by the drug concentration required for 50% inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccf107e3148c5e799d12a85253c01917
https://doi.org/10.1182/blood.v84.10.3440.3440
https://doi.org/10.1182/blood.v84.10.3440.3440
Autor:
Dan Costin, Robert Silber, Carl Rosenberg, Elizabeth W. Newcomb, Anju Thomas, Milan Potmesil, S el Rouby
Publikováno v:
Blood. 82:3452-3459
We studied 53 patients with B-cell chronic lymphocytic leukemia (B-CLL) and found mutations of the p53 gene in 15%. Patients with p53 gene mutations were found to have an aggressive form of B-CLL disease characterized by advanced Rai stage, rapid lym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39eaffb56460dba820ef3b50fe01270c
https://doi.org/10.1182/blood.v82.11.3452.3452
https://doi.org/10.1182/blood.v82.11.3452.3452
Autor:
Leonard Liebes, Michael Bruck, Charles M. Farber, Zoe Nakos Canellakis, Richard Brown, Denise Nevrla, Esperanza B. Papadopoulos, Robert Silber
Publikováno v:
Blood. 80:2038-2043
Glutathione (GSH) content may be the major determinant of a cell's sensitivity to cytotoxic alkylating agents. In the present study, the GSH concentration was determined in lymphocytes isolated from the blood of normal subjects and patients with chro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed28195c507729cc58114dbe7d4d22c
https://doi.org/10.1182/blood.v80.8.2038.2038
https://doi.org/10.1182/blood.v80.8.2038.2038
Autor:
S W Andresen, Robert Silber, M E Medof, S V Hazra, Shinichi Hirose, Lakshmeswari Ravi, G M Prince, M G Rosenfeld
Publikováno v:
Proceedings of the National Academy of Sciences. 89:6025-6029
To identify mannosyl (Man)-containing intermediates of the human glycoinositol phospholipid (GPI) anchor pathway and examine their expression in paroxysmal nocturnal hemoglobinuria (PNH), mannolipid products deriving from in vitro guanosine diphospha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cea0d4e9edce3775761dc25a08aaf52
https://doi.org/10.1073/pnas.89.13.6025
https://doi.org/10.1073/pnas.89.13.6025
Autor:
Susanne Muehlschlegel, MD, MPH, Sarah M. Perman, MD, MSCE, Jonathan Elmer, MD, MS, Adrianne Haggins, MD, MS, Natalie D. Teixeira Bailey, MPH, Jennifer Huang, PhD, Liz Jansky, MA, Jessica Kirchner, MA, Renee Kasperek-Wynn, RN, BSN, Paula Darby Lipman, PhD, Sharon D. Yeatts, PhD, Michael D. Fetters, MD, MPH, MA, Neal W. Dickert, MD, PhD, Robert Silbergleit, MD
Publikováno v:
Critical Care Explorations, Vol 4, Iss 3, p e0648 (2022)
OBJECTIVES:. Severe acute brain injury (SABI) from cardiac arrest and traumatic brain injury happens suddenly and unexpectedly, carrying high potential for lifelong disability with substantial prognostic uncertainty. Comprehensive assessments of fami
Externí odkaz:
https://doaj.org/article/76f69785a3fd42fcbd31ac907d1ebd80