Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Robert Sehlke"'
Autor:
Luke Stephen Tain, Robert Sehlke, Ralf Leslie Meilenbrock, Thomas Leech, Jonathan Paulitz, Manopriya Chokkalingam, Nagarjuna Nagaraj, Sebastian Grönke, Jenny Fröhlich, Ilian Atanassov, Matthias Mann, Andreas Beyer, Linda Partridge
Publikováno v:
eLife, Vol 10 (2021)
Reduced activity of the insulin/IGF signalling network increases health during ageing in multiple species. Diverse and tissue-specific mechanisms drive the health improvement. Here, we performed tissue-specific transcriptional and proteomic profiling
Externí odkaz:
https://doaj.org/article/f2129355d6fb4c9d8a2b6efe54ca2e46
Autor:
Luke S Tain, Robert Sehlke, Chirag Jain, Manopriya Chokkalingam, Nagarjuna Nagaraj, Paul Essers, Mark Rassner, Sebastian Grönke, Jenny Froelich, Christoph Dieterich, Matthias Mann, Nazif Alic, Andreas Beyer, Linda Partridge
Publikováno v:
Molecular Systems Biology, Vol 13, Iss 9, Pp 1-19 (2017)
Abstract Lowered activity of the insulin/IGF signalling (IIS) network can ameliorate the effects of ageing in laboratory animals and, possibly, humans. Although transcriptome remodelling in long‐lived IIS mutants has been extensively documented, th
Externí odkaz:
https://doaj.org/article/b2ab6e59cb074d5c909331ce01d05a47
Autor:
Michelle Huth, Laura Santini, Elena Galimberti, Julia Ramesmayer, Fabian Titz-Teixeira, Robert Sehlke, Michael Oberhuemer, Sarah Stummer, Veronika Herzog, Marius Garmhausen, Merrit Romeike, Anastasia Chugunova, Friederike Leesch, Laurenz Holcik, Klara Weipoltshammer, Andreas Lackner, Christian Schoefer, Arndt von Haeseler, Christa Buecker, Andrea Pauli, Stefan L. Ameres, Austin Smith, Andreas Beyer, Martin Leeb
Publikováno v:
Genes & Development. 36:348-367
Cell fate transitions depend on balanced rewiring of transcription and translation programs to mediate ordered developmental progression. Components of the nonsense-mediated mRNA decay (NMD) pathway have been implicated in regulating embryonic stem c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f43a207801747964fd993485ca9af9be
https://doi.org/10.1101/gad.347690.120
https://doi.org/10.1101/gad.347690.120
Autor:
Noemi Meszaros, Karin Lind, Robert Sehlke, Bojan Vilagos, Nikolaus Krall, Gregory I. Vladimer, Heinz Sill
Publikováno v:
British Journal of Haematology. 200
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::846ea41b7bec43d93081a7063ed43375
https://doi.org/10.1111/bjh.18557
https://doi.org/10.1111/bjh.18557
Autor:
Nieves Diaz, Holly Garratt, Aleksandra Zemla-Brown, Maria Dominguez, Eric Helmer, Isabella Alt, Robert Sehlke, Norbert Hieger, Thomas Winkler-Penz, Christophe Boudesco, Gregory Vladimer, Tom Wilde, Philip Evans, Antoine Italiano, Michael Krams
Publikováno v:
Cancer Research. 83:CT114-CT114
Background: EXS21546 (discovered in collaboration with Evotec) is a clinical stage A2AR selective antagonist with high potential in cancer immunotherapy as a combination agent. A completed healthy volunteer (HV) first-in-human (FIH) study is now bein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c6343da98243e741a479fc314908521
https://doi.org/10.1158/1538-7445.am2023-ct114
https://doi.org/10.1158/1538-7445.am2023-ct114
Autor:
Isabella Alt, Robert Sehlke, Anna Lobley, Claudia Baumgaertler, Maja Stulic, Klaus Hackner, Lucia Dzurillova, Edgar Petru, Laudia Hadjari, Judith Lafleur, Josef Singer, Nikolaus Krall, Jozef Šufliarsky, Lukas Hefler, Thorsten Füreder, Christina Taubert, Andrew Payne, Christophe Boudesco, Gregory Ian Vladimer
Publikováno v:
Cancer Research. 83:2151-2151
Background: Precision cancer medicine aims to identify the right drug for the right patient, enriching for patients more likely to respond to a particular treatment. This paradigm is gaining importance during the early clinical lifecycle of a new pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5677e1fbc820245029d44fe070a7b7bd
https://doi.org/10.1158/1538-7445.am2023-2151
https://doi.org/10.1158/1538-7445.am2023-2151
Publikováno v:
Journal of Bioinformatics and Systems Biology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bff4a1c00ba002a0d164293e5713972c
https://doi.org/10.26502/jbsb.5107034
https://doi.org/10.26502/jbsb.5107034
Autor:
Irene Gutierrez-Perez, Joost Van Ham, Valentin Aranha, Rin Okumura, Elisabeth Waltenberger, Isabella Alt, Claudia Baumgaertler, Maja Stulic, Edgar Petru, Christoph Minichsdorfer, Lukas Hefler, Judith Lafleur, Nikolaus Krall, Thorsten Füreder, Gregory Ian Vladimer, Robert Sehlke, Bojan Vilagos
Publikováno v:
Cancer Research. 82:1893-1893
Background: High unmet need of ovarian cancer (OC) suggests the discovery of new targeted therapeutics is crucial to improve patient prognosis. Unlike artificial model systems such as cell lines, primary cancer samples recapitulate the complexity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ecd89aed68384df1ce12f9e485ddf3e
https://doi.org/10.1158/1538-7445.am2022-1893
https://doi.org/10.1158/1538-7445.am2022-1893
Autor:
Jonathan Paulitz, Luke S Tain, Linda Partridge, Sebastian Grönke, Andreas Beyer, Ralf Leslie Meilenbrock, Jenny Fröhlich, Manopriya Chokkalingam, Matthias Mann, Robert Sehlke, Nagarjuna Nagaraj, Thomas Leech, Ilian Atanassov
Publikováno v:
Elife
eLife
eLife, Vol 10 (2021)
eLife
eLife, Vol 10 (2021)
Reduced activity of the insulin/IGF signalling network increases health during ageing in multiple species. Diverse and tissue-specific mechanisms drive the health improvement. Here, we performed tissue-specific transcriptional and proteomic profiling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d6f60c6507e24925d3e48c4d4770e8c
https://doi.org/10.7554/elife.67275
https://doi.org/10.7554/elife.67275
Autor:
Sebastian Grönke, Ilian Atanassov, Thomas Leech, Ralf Leslie Meilenbrock, Jenny Fröhlich, Jonathan Paulitz, Andreas Beyer, Luke S Tain, Matthias Mann, Nagrajuna Nagaraj, Manopriya Chokkalingam, Robert Sehlke, Linda Partridge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fbb4dc3f607d1b4dbd9a87a7eca0e68
https://doi.org/10.7554/elife.67275.sa2
https://doi.org/10.7554/elife.67275.sa2
