Zobrazeno 1 - 10
of 224
pro vyhledávání: '"Robert Saf"'
Autor:
Werner Seebacher, Michael Hoffelner, Ferdinand Belaj, Teresa Pirker, Muaaz Alajlani, Rudolf Bauer, Eva-Maria Pferschy-Wenzig, Robert Saf, Robert Weis
Publikováno v:
Molecules, Vol 28, Iss 19, p 6869 (2023)
Various 4-aminotetrahydropyridinylidene salts were treated with aldehydes in an alkaline medium. Their conversion to 5-substituted β-hydroxyketones in a one-step reaction succeeded only with an aliphatic aldehyde. Instead, aromatic aldehydes gave 5-
Externí odkaz:
https://doaj.org/article/eac5330073ce4d30929881c55c0eeb22
Autor:
Clemens Hinteregger, Johanna Dolensky, Werner Seebacher, Robert Saf, Pascal Mäser, Marcel Kaiser, Robert Weis
Publikováno v:
Molecules, Vol 28, Iss 1, p 307 (2022)
2,4-Diaminopyrimidines and (dialkylamino)azabicyclo-nonanes possess activity against protozoan parasites. A series of fused hybrids were synthesized and tested in vitro against pathogens of malaria tropica and sleeping sickness. The activities and se
Externí odkaz:
https://doaj.org/article/f01817200b324b09a3e44a868c2eb59f
Autor:
Johanna Dolensky, Clemens Hinteregger, Andreas Leitner, Werner Seebacher, Robert Saf, Ferdinand Belaj, Pascal Mäser, Marcel Kaiser, Robert Weis
Publikováno v:
Molecules, Vol 27, Iss 19, p 6217 (2022)
N-(Aminoalkyl)azabicyclo[3.2.2]nonanes possess antiplasmodial and antitrypanosomal activity. A series with terminal tetrazole or sulfonamido partial structure was prepared. The structures of all new compounds were confirmed by NMR and IR spectroscopy
Externí odkaz:
https://doaj.org/article/157ab529b45d437ca9a163f13b8a050b
Autor:
Theresa Hermann, Patrick Hochegger, Johanna Dolensky, Werner Seebacher, Eva-Maria Pferschy-Wenzig, Robert Saf, Marcel Kaiser, Pascal Mäser, Robert Weis
Publikováno v:
Pharmaceuticals, Vol 14, Iss 11, p 1109 (2021)
The 2-phenoxybenzamide 1 from the Medicines for Malaria Venture Malaria Box Project has shown promising multi-stage activity against different strains of P. falciparum. It was successfully synthesized via a retrosynthetic approach. Subsequently, twen
Externí odkaz:
https://doaj.org/article/176a80a80aa24a23946632a02a7cfb4b
Autor:
Patrick Hochegger, Johanna Dolensky, Werner Seebacher, Robert Saf, Marcel Kaiser, Pascal Mäser, Robert Weis
Publikováno v:
Molecules, Vol 26, Iss 18, p 5530 (2021)
A new series of compounds was prepared from 6-methoxyquinolin-8-amine or its N-(2-aminoethyl) analogue via Ugi-azide reaction. Their linkers between the quinoline and the tert-butyltetrazole moieties differ in chain length, basicity and substitution.
Externí odkaz:
https://doaj.org/article/a7fa9c5fb2f74efaa62080a64d558e5d
Autor:
Theresa Hermann, Patrick Hochegger, Johanna Dolensky, Werner Seebacher, Robert Saf, Marcel Kaiser, Pascal Mäser, Robert Weis
Publikováno v:
Pharmaceuticals, Vol 14, Iss 5, p 412 (2021)
An N-acylated furazan-3-amine of a Medicines for Malaria Venture (MMV) project has shown activity against different strains of Plasmodium falciparum. Seventeen new derivatives were prepared and tested in vitro for their activities against blood stage
Externí odkaz:
https://doaj.org/article/9ae661602cf54b29b9b1505e6303ea7a
Autor:
Armin Presser, Gunda Lainer, Nadine Kretschmer, Wolfgang Schuehly, Robert Saf, Marcel Kaiser, Marc-Manuel Kalt
Publikováno v:
Molecules, Vol 23, Iss 11, p 2902 (2018)
The cytotoxic and antiprotozoal activities of the phytoquinoide, jacaranone, and related compounds have been an ongoing topic in recent drug discovery. Starting from the natural product-derived cyclohexadienone scaffold, a series of nitrogen-containi
Externí odkaz:
https://doaj.org/article/0eabf5e76b3f451aa19f6670fed37d64
Autor:
Julia Wappel, César A. Urbina-Blanco, Mudassar Abbas, Jörg H. Albering, Robert Saf, Steven P. Nolan, Christian Slugovc
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 6, Iss 1, Pp 1091-1098 (2010)
The aims of this contribution are to present a straightforward synthesis of 2nd generation Hoveyda-type olefin metathesis catalysts bearing bromo and iodo ligands, and to disclose the subtle influence of the different anionic co-ligands on the cataly
Externí odkaz:
https://doaj.org/article/f7644d6abe304bb58513f9c0aa69516f
Autor:
Alexandra Moumtzi, Michael Trenker, Karlheinz Flicker, Elfriede Zenzmaier, Robert Saf, Albin Hermetter
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 3, Pp 565-582 (2007)
Lipid oxidation is now thought to be an initiating and sustaining event in atherogenesis. Oxidatively fragmented phospholipids, namely 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphocholine (PGPC) and 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphoch
Externí odkaz:
https://doaj.org/article/fac2a656347d4d2cb1295c899c90c84f
Autor:
Robert Weis, Antje Hüfner, Robert Saf, Ferdinand Belaj, Dietmar Kröpfl, Werner Seebacher
Publikováno v:
Molecules, Vol 10, Iss 3, Pp 521-533 (2005)
Benzylidene acetone reacts with thiocyanates derived from secondary amines in a one-pot reaction to give 4-aminobicyclo[2.2.2]octan-2-ones. The reaction mixture was investigated for the presence of possible intermediates using GC-MS. These intermedia
Externí odkaz:
https://doaj.org/article/9bdbdf2ed4654f30aef46b72ef39bc12