Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Robert Sabatini"'
Autor:
Rudo Kieft, Yang Zhang, Alexandre P Marand, Jose Dagoberto Moran, Robert Bridger, Lance Wells, Robert J Schmitz, Robert Sabatini
Publikováno v:
PLoS Genetics, Vol 16, Iss 2, p e1008390 (2020)
Base J, β-D-glucosyl-hydroxymethyluracil, is a modification of thymine DNA base involved in RNA Polymerase (Pol) II transcription termination in kinetoplastid protozoa. Little is understood regarding how specific thymine residues are targeted for J-
Externí odkaz:
https://doaj.org/article/38f4685d7d8849febf24f65cfe34bdb6
Autor:
David Reynolds, Brigitte T Hofmeister, Laura Cliffe, Magdy Alabady, T Nicolai Siegel, Robert J Schmitz, Robert Sabatini
Publikováno v:
PLoS Genetics, Vol 12, Iss 1, p e1005758 (2016)
Base J, β-D-glucosyl-hydroxymethyluracil, is a chromatin modification of thymine in the nuclear DNA of flagellated protozoa of the order Kinetoplastida. In Trypanosoma brucei, J is enriched, along with histone H3 variant (H3.V), at sites involved in
Externí odkaz:
https://doaj.org/article/265f4a03cd7f4f03be91e5bd7d3244f6
Publikováno v:
Nucleic Acids Research.
The genomes of kinetoplastids are organized into polycistronic transcription units that are flanked by a modified DNA base (base J, beta-D-glucosyl-hydroxymethyluracil). Previous work established a role of base J in promoting RNA polymerase II (Pol I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e8eb0480be5cd3ad0a9759dffb460c8
https://doi.org/10.1093/nar/gkad394
https://doi.org/10.1093/nar/gkad394
Autor:
Robert Bridger, Robert J. Schmitz, Yang Zhang, Alexandre P. Marand, Lance Wells, Jose Dagoberto Moran, Robert Sabatini, Rudo Kieft
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 16, Iss 2, p e1008390 (2020)
PLoS Genetics, 16(2):e1008390
PLoS Genetics, Vol 16, Iss 2, p e1008390 (2020)
PLoS Genetics, 16(2):e1008390
Base J, β-D-glucosyl-hydroxymethyluracil, is a modification of thymine DNA base involved in RNA Polymerase (Pol) II transcription termination in kinetoplastid protozoa. Little is understood regarding how specific thymine residues are targeted for J-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89b9c28e11dfc6d8280ec6c15b63278c
https://pubmed.ncbi.nlm.nih.gov/32084124
https://pubmed.ncbi.nlm.nih.gov/32084124
Autor:
David L. Reynolds, Brigitte T. Hofmeister, Robert J. Schmitz, Stephen M. Beverley, T. Nicolai Siegel, Robert Sabatini, Laura Cliffe, Britta A. Anderson
Publikováno v:
Molecular Microbiology. 101:559-574
Summary The genomes of kinetoplastids are organized into polycistronic gene clusters that are flanked by the modified DNA base J. Previous work has established a role of base J in promoting RNA polymerase II termination in Leishmania spp. where the l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b923bbce61217fe957a6a6a8d9a86f9
https://doi.org/10.1111/mmi.13408
https://doi.org/10.1111/mmi.13408
Autor:
Janina Golob Deeb, Thomas C. Waldrop, Christopher R. Richardson, Sharon K. Lanning, Robert Sabatini, Caroline K. Carrico, John H. White
Publikováno v:
Journal of periodontologyREFERENCES. 90(11)
Background The aim of this survey was threefold: (1) describe the demographics of periodontists and their practices in Virginia; (2) explore periodontists' perceptions of the impact that changes in the field of dentistry (i.e. increasing corporate de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb90189d92b1c8133d6cf896b52cb95
https://pubmed.ncbi.nlm.nih.gov/31257595
https://pubmed.ncbi.nlm.nih.gov/31257595
Autor:
Daniel Nilsson, Torsten Ochsenreiter, Todd Minning, Kapila Gunasekera, Dilrukshi K. Ekanayake, Rick L. Tarleton, Brent Weatherly, Robert Sabatini
Publikováno v:
Molecular and cellular biology. 37(15)
Unlike other eukaryotes, the protein-coding genes of Trypanosoma cruzi are arranged in large polycistronic gene clusters transcribed by polymerase II (Pol II). Thus, it is thought that trypanosomes rely solely on posttranscriptional processes to regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f113e87ceb99559e57e8a28fc4bdf85c
https://pubmed.ncbi.nlm.nih.gov/21321080
https://pubmed.ncbi.nlm.nih.gov/21321080
Publikováno v:
Biology methods and protocols
Recently, 5-hydroxymethyluracil (5hmU) was identified in mammalian genomic DNA as an oxidative product of thymine by the ten-eleven translocation (TET) proteins. While the biological role of this modification remains unclear, identifying its genomic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b6833c1fd41c4e60edad105dca91ab5
http://europepmc.org/articles/PMC5741180
http://europepmc.org/articles/PMC5741180
Publikováno v:
Journal of the American Society for Mass Spectrometry. 25:1763-1770
β-D-glucosyl-5-hydroxymethyluracil (base J) is a hyper-modified nucleobase found in the nuclear DNA of kinetoplastid parasites. With replacement of a fraction of thymine in DNA, J is localized primarily in telomeric regions of all organisms carrying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a3f2625cf1ed885f6654e83c8fe2a52
https://doi.org/10.1007/s13361-014-0960-6
https://doi.org/10.1007/s13361-014-0960-6
Publikováno v:
Journal of Biological Chemistry. 289:20273-20282
O-linked glucosylation of thymine in DNA (base J) is an important regulatory epigenetic mark in trypanosomatids. β-d-glucopyranosyloxymethyluracil (base J) synthesis is initiated by the JBP1/2 enzymes that hydroxylate thymine, forming 5-hydroxymethy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd8e26a0c2f79c66478e083a4948f5c3
https://doi.org/10.1074/jbc.m114.579821
https://doi.org/10.1074/jbc.m114.579821