Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Robert S.U. Baker"'
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 285:19-26
Micronucleus induction, chromosomal damage and aneuploidy were evaluated in whole skin keratinocyte cultures derived from HRA/Skh mice after single in vivo applications of 0.256, 2.56 and 25.6 μg (1, 10 and 100 nmoles) of the carcinogen, 7,12-dimeth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6015d829c94fcded2dbc2cc3b36af75a
https://doi.org/10.1016/0027-5107(93)90047-j
https://doi.org/10.1016/0027-5107(93)90047-j
Publikováno v:
Carcinogenesis. 13:329-332
The most potent carcinogen of the cyclopenta[a]phenanthrene series, 15, 16-dihydro-11-methylcyclopenta[a]phenanthren-17-one and its non-carcinogenic, unmethylated parent compound, were compared for their abilities to induce micronuclei in epidermal k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac89837dc92bd6815d833773f8dd30f9
https://doi.org/10.1093/carcin/13.3.329
https://doi.org/10.1093/carcin/13.3.329
Publikováno v:
Mutagenesis. 7:199-203
Phorbol esters are chemical compounds which have the ability to promote carcinogenesis in the skin of mice. In the HRA/Skh mouse strain, an initiation-promotion assay substantiated evidence that mezerein acts as a complete promoter. Complete promotio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f05e25ec24dff1e0a080495a8e0e352
https://doi.org/10.1093/mutage/7.3.199
https://doi.org/10.1093/mutage/7.3.199
Publikováno v:
Environmental and molecular mutagenesis. 17(3)
Detection of micronuclei (MN) in skin cells from HRA/Skh hairless mice treated with chemical or physical agents may prove informative in qualitative and quantitative studies of skin carcinogenesis. MN induction and cell survival were estimated in cyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceff500d0c155622ddbcdc039cdb32ab
https://pubmed.ncbi.nlm.nih.gov/1902414
https://pubmed.ncbi.nlm.nih.gov/1902414
Publikováno v:
Mutation research. 230(1)
Toxaphene is genotoxic in mammalian cell systems and also inhibits cell replication. It was therefore used to investigate possible masking of SCE induction due to cell-cycle delay. In this study, toxaphene-treated Chinese hamster lung (Don) cells exh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98af66d9f187d9ed27348b9cd67e88dc
https://pubmed.ncbi.nlm.nih.gov/2342495
https://pubmed.ncbi.nlm.nih.gov/2342495
Publikováno v:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 28(3)
Mutagen production was examined in lamb and beef in relation to certain common household cooking methods. Mutagenicity was assessed, after extraction of the basic fraction of cooked meat samples, using Salmonella typhimurium strain TA1538 with added
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::702610561dd7f6680bc210dbf1cc5983
https://pubmed.ncbi.nlm.nih.gov/2344988
https://pubmed.ncbi.nlm.nih.gov/2344988
Autor:
Shuilin He, Robert S.U. Baker
Publikováno v:
Environmental and Molecular Mutagenesis. 14:1-5
Keratinocytes from mouse skin were cultured for a short period in vitro following single or multiple treatments at low dose levels in vivo with the known chromosome-damaging agent triethylenemelamine (TEM). The chemical was applied to the skin of HRA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7230a0b7912421bb59c769a382c419a
https://doi.org/10.1002/em.2850140102
https://doi.org/10.1002/em.2850140102
Autor:
John Ellis, Andrew Arlauskas, Phillip T. Crisp, Antonio M. Bonin, Ram K. Tandon, Robert S.U. Baker
Publikováno v:
Mutation Research/Genetic Toxicology. 138:127-132
After treatment with potassium chromate at concentrations causing ultramicroscopic cellular lesions, a significant proportion (up to 75%) of TA100 colonies fail to replicate on fresh minimal plates containing biotin. This suggests that chromium(VI) m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14446f49ff93d8cbea544513fa9288d2
https://doi.org/10.1016/0165-1218(84)90034-x
https://doi.org/10.1016/0165-1218(84)90034-x
Publikováno v:
Mutation Research/Genetic Toxicology. 118:103-116
SCE induction in Chinese hamster Don (lung) cells was compared with that in CHO (ovary) cells exposed under identical conditions to 14 known mutagens. Test protocols used for comparison were selected following a study of Don and CHO cell responses to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11018918dc31b82e1a5dbf69dcebe1e7
https://doi.org/10.1016/0165-1218(83)90120-9
https://doi.org/10.1016/0165-1218(83)90120-9
Publikováno v:
Mutation Research/Genetic Toxicology. 158:111-117
Liver microsomal enzymes are essential for the detection of benzo[a]pyrene (B[a]P)-mediated mutagenesis in the Salmonella/mammalian microsome mutagenicity test and, furthermore, this mutagenicity is considerably enhanced by induction of hepatic enzym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9619bf0b9d7adc22650540a9d382d6b9
https://doi.org/10.1016/0165-1218(85)90072-2
https://doi.org/10.1016/0165-1218(85)90072-2