Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Robert S. Slaughter"'
Autor:
Gloria C. Koo, Laurie A. Castonguay, Mary Jo Staruch, Randal M. Bugianesi, John P. Felix, George A. Doss, Robert S. Slaughter, Marty S. Springer, Andrew Kotliar, Sookhee Ha, Kathleen M. Rupprecht, William H. Parsons, Gregory J. Kaczorowski, Kashmira Shah, Shouwu Miao, Jianming Bao, Maria L. Garcia, Frank Kayser, Robert K. Baker
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:447-451
Kv1.3, the voltage-gated potassium channel in human T cells, represents a new target for treating immunosuppression and autoimmune diseases. Correolide (1), a pentacyclic natural product, is a potent and selective Kv1.3 channel blocker. Simplificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b217212f1114b7e5c9d40397d6232c7
https://doi.org/10.1016/j.bmcl.2004.10.058
https://doi.org/10.1016/j.bmcl.2004.10.058
Autor:
Kathleen M. Rupprecht, John P. Felix, Mary Matyskiela, Yui S. Tang, Gregory J. Kaczorowski, Robert S. Slaughter, Maria L. Garcia, William A. Schmalhofer
Publikováno v:
Biochemistry. 42:4733-4743
Di-substituted cyclohexyl (DSC) derivatives inhibit the voltage-gated potassium channel, K(v)1.3, and have immunosuppressant activity (Schmalhofer et al. (2002) Biochemistry 41, 7781-7794). This class of inhibitors displays Hill coefficients of near
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a73cb79e9ae45004fe42bb2fa1cec4
https://doi.org/10.1021/bi034122q
https://doi.org/10.1021/bi034122q
Autor:
Maria L. Garcia, Frank Kayser, Peter J. Sinclair, Mary Jo Staruch, Andrew Kotliar, Nancy N. Tsou, William H. Parsons, Marty S. Springer, Gloria C. Koo, Kathleen M. Rupprecht, William A. Schmalhofer, Gregory J. Kaczorowski, Robert S. Slaughter, Joung L. Goulet, Kashmira Shah, Jianming Bao, Xingfang J. Hong, Frederick Wong, Shouwu Miao
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1161-1164
The voltage-gated potassium channel, Kv1.3, is present in human T-lymphocytes. Blockade of Kv1.3 results in T-cell depolarization, inhibition of T-cell activation, and attenuation of immune responses in vivo. A class of benzamide Kv1.3 channel inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd33db6982167b726fc36794cabfa008
https://doi.org/10.1016/s0960-894x(03)00014-3
https://doi.org/10.1016/s0960-894x(03)00014-3
Autor:
Owen B. McManus, Gloria C. Koo, Mary Jo Staruch, Mary Matyskiela, Randal M. Bugianesi, Markus Hanner, John P. Felix, William A. Schmalhofer, Denise Wunderler, B G Green, Robert S. Slaughter, Ana-Rosa Linde-Arias, Cristiano G. Ponte, Gregory J. Kaczorowski, Lucia Velasco, Kathleen M. Rupprecht, William H. Parsons, Shouwu Miao, Maria L. Garcia, Jianming Bao
Publikováno v:
Biochemistry. 41:7781-7794
The voltage-gated potassium channel, K(v)1.3, is a novel target for development of immunosuppressants. Using a functional (86)Rb(+) efflux assay, a new class of high-affinity K(v)1.3 inhibitors has been identified. The initial active in this series,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c12018acfcca94b56fc83951d2d375b4
https://doi.org/10.1021/bi025722c
https://doi.org/10.1021/bi025722c
Autor:
Robert S. Slaughter, John P. Felix, Sheo B. Singh, Deborah L. Zink, Gerald F. Bills, Anne W. Dombrowski, Gabe Dezeny, Michael A. Goetz
Publikováno v:
Organic Letters. 3:247-250
[figure: see text] Blockers of the voltage-gated potassium channel Kv1.3 are potential immunosuppressants. Candelalides A-C are three novel diterpenoid pyrones that block this channel. The structure, stereochemistry, and activity against Kv1.3 are de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f095a85e8ea13b89c1898d2b8f6c9b6d
https://doi.org/10.1021/ol006891x
https://doi.org/10.1021/ol006891x
Autor:
Markus Hanner, B G Green, Carmen Bordallo, Jessica Liu, William A. Schmalhofer, Maria L. Garcia, Gregory J. Kaczorowski, Robert S. Slaughter
Publikováno v:
Journal of Biological Chemistry. 274:25237-25244
Correolide, a novel nortriterpene natural product, potently inhibits the voltage-gated potassium channel, K(v)1.3, and [(3)H]dihydrocorreolide (diTC) binds with high affinity (K(d) approximately 10 nM) to membranes from Chinese hamster ovary cells th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b15034fa394a30e0c0dab3313fea2e7
https://doi.org/10.1074/jbc.274.36.25237
https://doi.org/10.1074/jbc.274.36.25237
Autor:
Robert S. Slaughter, Giselle Tamayo-Castillo, Deborah L. Zink, Michael A. Goetz, Otto D. Hensens, Francisco Morales, John P. Felix, Robert P. Borris, Richard G. Ball
Publikováno v:
Tetrahedron Letters. 39:2895-2898
The isolation and structure elucidation of two novel nor-triterpenoid K V 1.3 potassium channel blockers correolide and dehydrocorreolide from the Costa Rican tree Spachea correae are reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ffd25792d7b1725ac6200c8cbacc2f9
https://doi.org/10.1016/s0040-4039(98)00427-4
https://doi.org/10.1016/s0040-4039(98)00427-4
Autor:
Robert O. A. Koch, Robert S. Slaughter, Hans-Günther Knaus, Siegmund G. Wanner, Markus Hanner, Maria L. Garcia, Alexandra Koschak, Christoph Schwarzer, Gregory J. Kaczorowski
Publikováno v:
Journal of Biological Chemistry. 272:27577-27581
Neurons require specific patterns of K+ channel subunit expression as well as the precise coassembly of channel subunits into heterotetrameric structures for proper integration and transmission of electrical signals. In vivo subunit coassembly was in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25ca68b76d516b4bb626ce07d77764b9
https://doi.org/10.1074/jbc.272.44.27577
https://doi.org/10.1074/jbc.272.44.27577
Autor:
Hans-Günther Knaus, Siegmund G. Wanner, Maria L. Garcia, Reid J. Leonard, John P. Felix, Gregory J. Kaczorowski, Randal M. Bugianesi, Robert O. A. Koch, Scott P. Stevens, Lisa M. H. Helms, Robert S. Slaughter
Publikováno v:
Biochemistry. 36:3737-3744
Voltage-gated potassium (K(V)) channels play key roles in setting the resting potential and in the activation cascade of human peripheral T lymphocytes. Margatoxin (MgTX), a 39-amino acid peptide from Centruroides margaritatus, is a potent inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d0a880467e6b335261e03716c0f3af7
https://doi.org/10.1021/bi962351p
https://doi.org/10.1021/bi962351p
Publikováno v:
Current Pharmaceutical Design. 2:610-623
Human peripheral blood T lymphocytes possess a known complement of only three types of cation channels: a voltage-gated potassium channel, Ky 1.3, a number of small conductance calcium-activated potassium channels, Kea, and a store-depletion activate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::847a8295c0a9cb4fa223d65df0ed6c94
https://doi.org/10.2174/1381612802666221004185819
https://doi.org/10.2174/1381612802666221004185819