Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Robert S. Mansbach"'
Autor:
Karen Joy Shaw, Min Hee Lee, Padmaja Paderu, Cristina Jiménez-Ortigosa, Steven Park, Yanan Zhao, Annie Lee, David S. Perlin, Robert S. Mansbach
Publikováno v:
Antimicrobial Agents and Chemotherapy. 62
APX001 is a first-in-class, intravenous and orally available, broad-spectrum antifungal agent in clinical development for the treatment of life-threatening invasive fungal infections. The half-life of APX001A, the active moiety of APX001, is signific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39c55f704d21d9a64ddd44c70d42563c
https://doi.org/10.1128/aac.00425-18
https://doi.org/10.1128/aac.00425-18
Autor:
Yanan, Zhao, Min Hee, Lee, Padmaja, Paderu, Annie, Lee, Cristina, Jimenez-Ortigosa, Steven, Park, Robert S, Mansbach, Karen Joy, Shaw, David S, Perlin
Publikováno v:
Antimicrobial agents and chemotherapy. 62(10)
APX001 is a first-in-class, intravenous and orally available, broad-spectrum antifungal agent in clinical development for the treatment of life-threatening invasive fungal infections. The half-life of APX001A, the active moiety of APX001, is signific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d5c1f62093e25d4bd7122c3a671eddf5
https://pubmed.ncbi.nlm.nih.gov/30012766
https://pubmed.ncbi.nlm.nih.gov/30012766
Autor:
Kerri A. Schoedel, Robert S. Mansbach
Publikováno v:
Pharmaceutical Medicine. 29:141-153
Prescription drugs with actions in the central nervous system (CNS) can produce effects on mood, perception, cognition, behavior, and brain reward processes that can result in pleasurable intoxication and subsequent drug-seeking behavior, and in some
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d62613e92f4d5d20fd3793cf77aefcb
https://doi.org/10.1007/s40290-015-0095-5
https://doi.org/10.1007/s40290-015-0095-5
Publikováno v:
Drug and Alcohol Dependence. 112:173-177
The scientific and regulatory assessment of abuse and dependence potential of drugs involves a multi-layered evaluation of its properties related to chemistry, formulation, pharmacology, animal behavior and clinical response. In addition to the prima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a73e83d8d50105683cdfd088552306d
https://doi.org/10.1016/j.drugalcdep.2010.07.001
https://doi.org/10.1016/j.drugalcdep.2010.07.001
Publikováno v:
Behavioural Pharmacology. 18:731-743
Development of N-methyl-D-aspartate (NMDA) antagonists for a variety of disorders has been hindered by their production of phencyclidine (PCP)-like psychological effects and abuse potential. There is, however, evidence to suggest that this problem mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6f8e12348bd3f50afbec6b15d476016
https://doi.org/10.1097/fbp.0b013e3282f14ed6
https://doi.org/10.1097/fbp.0b013e3282f14ed6
Autor:
Jack E. Henningfield, Charles Grudzinskas, Eric C. Strain, Robert S. Mansbach, Cynthia G. McCormick, Chris Ellyn Johanson, C. Wright, Roland R. Griffiths, Charles W. Gorodetzky, Sidney H. Schnoll, Robert L. Balster
Publikováno v:
Drug and Alcohol Dependence. 83:S77-S82
A scientific meeting was held in April 2005 to consider how the formulation of medications might impact on their potential for abuse. The background papers prepared for this meeting, as well as abstracts of volunteered presentations, are published in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bb12086c2ace6d63cf021b23559cb41
https://doi.org/10.1016/j.drugalcdep.2006.02.008
https://doi.org/10.1016/j.drugalcdep.2006.02.008
Publikováno v:
Drug and Alcohol Dependence. 83:S15-S22
The availability of increasingly sophisticated drug formulations and delivery devices has created new opportunities in drug development. These newer approaches can result in improved drug bioavailability, or they can alter key pharmacokinetic paramet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8384261a14a7e819355fae869e95b43
https://doi.org/10.1016/j.drugalcdep.2005.10.018
https://doi.org/10.1016/j.drugalcdep.2005.10.018
Autor:
Thomas I. Davis, Carol B. Fox, Michael C. Wirtz, Michael G. Vetelino, F. David Tingley, Krista E. Bianco, Robert S. Mansbach, David W. Schulz, Jotham Wadsworth Coe, Crystal G. Bashore, Hans Rollema, Eric P. Arnold, Paige Roanne Palmer Brooks, Steven B. Sands, Brian T. O’Neill, Lorraine A. Lebel
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:4889-4897
3,5-Bicyclic aryl piperidines are a new class of high-affinity alpha4beta2 nicotinic receptor agents. We have sought nicotinic receptor partial agonists of the alpha4beta2 nicotinic acetylcholine receptor for smoking cessation, and a number of compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04dfd8d682666f8daba933d872fb0b4a
https://doi.org/10.1016/j.bmcl.2005.08.035
https://doi.org/10.1016/j.bmcl.2005.08.035
Autor:
Yi Lu, Jotham Wadsworth Coe, Thomas I. Davis, David W. Schulz, Lorraine A. Lebel, Robert S. Mansbach, Paige Roanne Palmer Brooks, Michael C. Wirtz, Alka Shrikhande, Michael G. Vetelino, Leslie K. Chambers, Eric P. Arnold, Eric Schaeffer, Brian T. O’Neill, Steven B. Sands, and F. David Tingley, James Heym, Carol B. Fox, Huang Jianhua, Charles C. Rovetti, Hans Rollema
Publikováno v:
Modern Drug Synthesis
Herein we describe a novel series of compounds from which varenicline (1, 6,7,8,9-tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine) has been identified for smoking cessation. Neuronal nicotinic acetylcholine receptors (nAChRs) mediate the dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d09a810f898eefeb7fda3442e4b30f
https://doi.org/10.1021/jm050069n
https://doi.org/10.1021/jm050069n
Publikováno v:
Drug and Alcohol Dependence. 70:S73-S85
Evaluation of abuse liability is one of many obligations incurred by industrial sponsors in the development of medications acting on substrates in the central nervous system. In addition to providing the information necessary for a scheduling recomme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::579f6f13afe63cd9f3ae9c0b30325ff7
https://doi.org/10.1016/s0376-8716(03)00100-5
https://doi.org/10.1016/s0376-8716(03)00100-5