Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Robert S. Illingworth"'
Autor:
Katy McLaughlin, Ilya M. Flyamer, John P. Thomson, Heidi K. Mjoseng, Ruchi Shukla, Iain Williamson, Graeme R. Grimes, Robert S. Illingworth, Ian R. Adams, Sari Pennings, Richard R. Meehan, Wendy A. Bickmore
Publikováno v:
Cell Reports, Vol 29, Iss 7, Pp 1974-1985.e6 (2019)
Summary: The DNA hypomethylation that occurs when embryonic stem cells (ESCs) are directed to the ground state of naive pluripotency by culturing in two small molecule inhibitors (2i) results in redistribution of polycomb (H3K27me3) away from its tar
Externí odkaz:
https://doaj.org/article/494966c0bb4449d6817be1b988d20ad1
Autor:
Richard R. Meehan, Michael Schwarz, Jonathan G. Moggs, C. Roland Wolf, Amanda J. Drake, Marcus J. Lyall, Alastair R.W. Kerr, Shaun Webb, Robert S. Illingworth, Remi Terranova, Arne Muller, Harri Lempiäinen, Elif B. Unterberger, Raffaele Ottaviano, John P. Thomson
List of genes exhibiting loss of promoter core 5hmC and gain of 5mC in PB driven liver tumours
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::204a81b28e3bbb9b87a3c03ec38628d7
https://doi.org/10.1158/0008-5472.22407830.v1
https://doi.org/10.1158/0008-5472.22407830.v1
Autor:
Richard R. Meehan, Michael Schwarz, Jonathan G. Moggs, C. Roland Wolf, Amanda J. Drake, Marcus J. Lyall, Alastair R.W. Kerr, Shaun Webb, Robert S. Illingworth, Remi Terranova, Arne Muller, Harri Lempiäinen, Elif B. Unterberger, Raffaele Ottaviano, John P. Thomson
Describes more detailed methods employed in main manuscript and supplementary data.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8676464e8fdde952a88c3b0e1c967c09
https://doi.org/10.1158/0008-5472.22407821.v1
https://doi.org/10.1158/0008-5472.22407821.v1
Autor:
Richard R. Meehan, Michael Schwarz, Jonathan G. Moggs, C. Roland Wolf, Amanda J. Drake, Marcus J. Lyall, Alastair R.W. Kerr, Shaun Webb, Robert S. Illingworth, Remi Terranova, Arne Muller, Harri Lempiäinen, Elif B. Unterberger, Raffaele Ottaviano, John P. Thomson
17 Supplementary Figures supporting the data and interpretation presented in the main manuscript.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04fd3078fe2067fb82accfbd2c5071a4
https://doi.org/10.1158/0008-5472.22407824
https://doi.org/10.1158/0008-5472.22407824
Autor:
Richard R. Meehan, Michael Schwarz, Jonathan G. Moggs, C. Roland Wolf, Amanda J. Drake, Marcus J. Lyall, Alastair R.W. Kerr, Shaun Webb, Robert S. Illingworth, Remi Terranova, Arne Muller, Harri Lempiäinen, Elif B. Unterberger, Raffaele Ottaviano, John P. Thomson
Lists of genes transcritpionally altered following chronic PB exposure and in the resulting liver tumours (see figure 4a)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d167390efd62264c36ebd6a43d702cea
https://doi.org/10.1158/0008-5472.22407827.v1
https://doi.org/10.1158/0008-5472.22407827.v1
Autor:
Sari Pennings, Robert S. Illingworth, Heidi K. Mjoseng, John P. Thomson, Iain Williamson, Wendy A. Bickmore, Ilya M. Flyamer, Katy A. Mclaughlin, Richard R. Meehan, Graeme R. Grimes, Ruchi Shukla, Ian R. Adams
Publikováno v:
Cell Reports, Vol 29, Iss 7, Pp 1974-1985.e6 (2019)
Cell Reports
Mclaughlin, K, Flyamer, I M, Thomson, J P, Mjoseng, H K, Shukla, R, Williamson, I, Grimes, G R, Illingworth, R S, Adams, I R, Pennings, S, Meehan, R R & Bickmore, W A 2019, ' DNA Methylation Directs Polycomb-Dependent 3D Genome Re-organization in Naive Pluripotency ', vol. 29, no. 7, pp. 1974-1985.e6 . https://doi.org/10.1016/j.celrep.2019.10.031
McLaughlin, K, Flyamer, I M, Thomson, J P, Mjoseng, H K, Shukla, R, Williamson, I, Grimes, G R, Illingworth, R S, Adams, I R, Pennings, S, Meehan, R R & Bickmore, W A 2019, ' DNA Methylation Directs Polycomb-Dependent 3D Genome Re-organization in Naive Pluripotency ', Cell Reports, vol. 29, no. 7, pp. 1974-1985.e6 . https://doi.org/10.1016/j.celrep.2019.10.031, https://doi.org/10.1016/j.celrep.2019.10.031
Cell Reports
Mclaughlin, K, Flyamer, I M, Thomson, J P, Mjoseng, H K, Shukla, R, Williamson, I, Grimes, G R, Illingworth, R S, Adams, I R, Pennings, S, Meehan, R R & Bickmore, W A 2019, ' DNA Methylation Directs Polycomb-Dependent 3D Genome Re-organization in Naive Pluripotency ', vol. 29, no. 7, pp. 1974-1985.e6 . https://doi.org/10.1016/j.celrep.2019.10.031
McLaughlin, K, Flyamer, I M, Thomson, J P, Mjoseng, H K, Shukla, R, Williamson, I, Grimes, G R, Illingworth, R S, Adams, I R, Pennings, S, Meehan, R R & Bickmore, W A 2019, ' DNA Methylation Directs Polycomb-Dependent 3D Genome Re-organization in Naive Pluripotency ', Cell Reports, vol. 29, no. 7, pp. 1974-1985.e6 . https://doi.org/10.1016/j.celrep.2019.10.031, https://doi.org/10.1016/j.celrep.2019.10.031
Summary The DNA hypomethylation that occurs when embryonic stem cells (ESCs) are directed to the ground state of naive pluripotency by culturing in two small molecule inhibitors (2i) results in redistribution of polycomb (H3K27me3) away from its targ
Publikováno v:
Flyamer, I M, Illingworth, R & Bickmore, W 2020, ' Coolpup.py: versatile pile-up analysis of Hi-C data ', Bioinformatics . https://doi.org/10.1093/bioinformatics/btaa073
Bioinformatics
Bioinformatics
MotivationHi-C is currently the method of choice to investigate the global 3D organisation of the genome. A major limitation of Hi-C is the sequencing depth required to robustly detect loops in the data. A popular approach used to mitigate this issue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afcd1544b41d31fbb6a3378ba9f13957
https://www.pure.ed.ac.uk/ws/files/134475161/btaa073.pdf
https://www.pure.ed.ac.uk/ws/files/134475161/btaa073.pdf
Autor:
Wendy A. Bickmore, Ilya M. Flyamer, Robert S. Illingworth, Iain Williamson, Shelagh Boyle, Dipta Sengupta
Publikováno v:
Boyle, S, Flyamer, I M, Williamson, I, Sengupta, D, Bickmore, W & Illingworth, R 2020, ' A Central Role for Canonical PRC1 in Shaping the 3D Nuclear Landscape ', Genes & Development, vol. 34, no. 13-14, pp. 931-949 . https://doi.org/10.1101/gad.336487.120
Polycomb group (PcG) proteins silence gene expression by chemically and physically modifying chromatin. A subset of PcG target loci are compacted and cluster in the nucleus to form observable bodies; a conformation which is thought to contribute to g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae05a849c2fe70382163013698908a1b
https://doi.org/10.1101/2019.12.15.876771
https://doi.org/10.1101/2019.12.15.876771
Autor:
Robert S Illingworth, Ulrike Gruenewald-Schneider, Shaun Webb, Alastair R W Kerr, Keith D James, Daniel J Turner, Colin Smith, David J Harrison, Robert Andrews, Adrian P Bird
Publikováno v:
PLoS Genetics, Vol 6, Iss 9, p e1001134 (2010)
CpG islands (CGIs) are vertebrate genomic landmarks that encompass the promoters of most genes and often lack DNA methylation. Querying their apparent importance, the number of CGIs is reported to vary widely in different species and many do not co-l
Externí odkaz:
https://doaj.org/article/95304a60b0de42c9a3332c3032cc4157
Autor:
Robert S. Illingworth
Publikováno v:
Illingworth, R 2019, ' Chromatin Folding and Nuclear Architecture: PRC1 Function in 3D ', Current Opinion in Genetics and Development . https://doi.org/10.1016/j.gde.2019.06.006
Current Opinion in Genetics & Development
Current Opinion in Genetics & Development
Embryonic development requires the intricate balance between the expansion and specialisation of defined cell types in time and space. The gene expressionprogrammes that underpin this balance are regulated, in part, by modulating thechemical and stru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd45003e05bb917c609de48a6b09250c
https://www.pure.ed.ac.uk/ws/files/99184540/RI_Final_Article_Figs.pdf
https://www.pure.ed.ac.uk/ws/files/99184540/RI_Final_Article_Figs.pdf