Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Robert S. Hoover"'
Autor:
Ye Bi, Chunmei Li, Yiqian Zhang, Yunman Wang, Shan Chen, Qiang Yue, Robert S. Hoover, Xiaonan H. Wang, Eric Delpire, Douglas C. Eaton, Jieqiu Zhuang, Hui Cai
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
SPS1-related proline/alanine-rich kinase (SPAK) plays important roles in regulating the function of numerous ion channels and transporters. With-no-lysine (WNK) kinase phosphorylates SPAK kinase to active the SPAK signaling pathway. Our previous stud
Externí odkaz:
https://doaj.org/article/b156aa3b648949bb905467aea938a42b
Publikováno v:
Biology, Vol 10, Iss 12, p 1335 (2021)
The thiazide-sensitive sodium chloride cotransporter (NCC) in the distal convoluted tubule is responsible for reabsorbing up to one-tenth of the total filtered load of sodium in the kidney. The actin cytoskeleton is thought to regulate various transp
Externí odkaz:
https://doaj.org/article/bcff81eb8a47403eb8db89853b89fa7f
Autor:
Brandi M. Wynne, Abinash C. Mistry, Otor Al-Khalili, Rickta Mallick, Franziska Theilig, Douglas C. Eaton, Robert S. Hoover
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Distal sodium transport is a final step in the regulation of blood pressure. As such, understanding how the two main sodium transport proteins, the thiazide-sensitive sodium chloride cotransporter (NCC) and the epithelial sodium channel (ENa
Externí odkaz:
https://doaj.org/article/5a57c393beb9449b97dd8ad6093995d4
Autor:
Yunmeng Liu, Tonya M. Rafferty, Sung W. Rhee, Jessica S. Webber, Li Song, Benjamin Ko, Robert S. Hoover, Beixiang He, Shengyu Mu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
T cells contribute to development of high blood pressure but their role in salt-sensitive hypertension is less clear. Liuet al. show that CD8+ T cells upregulate and activate Na-Cl co-transporter NCC in distal convoluted tubules via direct cell-cell
Externí odkaz:
https://doaj.org/article/b1e9f4a1108846c78a1934ac7851a680
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Acute lung injury leading to acute respiratory distress (ARDS) is a global health concern. ARDS patients have significant pulmonary inflammation leading to flooding of the pulmonary alveoli. This prevents normal gas exchange with consequent hypoxemia
Externí odkaz:
https://doaj.org/article/45e7c378093f4e4f8572b7e136173ce1
Autor:
Brandi M. Wynne, Trinity K. Samson, Hayley C. Moyer, Henrieke J. van Elst, Auriel S. Moseley, Gillian Hecht, Oishi Paul, Otor Al-Khalili, Celso Gomez-Sanchez, Benjamin Ko, Douglas C. Eaton, Robert S. Hoover
Publikováno v:
American Journal of Physiology-Cell Physiology. 323:C1512-C1523
Hypertension is characterized by increased sodium (Na+) reabsorption along the aldosterone-sensitive distal nephron (ASDN) as well as chronic systemic inflammation. Interleukin-6 (IL-6) is thought to be a mediator of this inflammatory process. Intere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f19f9118f09e658af95e14fbe7d2505
https://doi.org/10.1152/ajpcell.00272.2021
https://doi.org/10.1152/ajpcell.00272.2021
Autor:
Lance N. Benson, Yunmeng Liu, Xiangting Wang, Yunzhao Xiong, Sung W. Rhee, Yunping Guo, Katherine S. Deck, Christoph J. Mora, Lin-Xi Li, Lu Huang, J. Tucker Andrews, Zhiqiang Qin, Robert S. Hoover, Benjamin Ko, Ryan M. Williams, Daniel A. Heller, Edgar A. Jaimes, Shengyu Mu
Publikováno v:
Circ Res
Background: Renal T cells contribute importantly to hypertension, but the underlying mechanism is incompletely understood. We reported that CD8Ts directly stimulate distal convoluted tubule cells (DCTs) to increase NCC (sodium chloride co-transporter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de4eb0ebb86f1c733cd4bc8268766da5
https://pubmed.ncbi.nlm.nih.gov/35430873
https://pubmed.ncbi.nlm.nih.gov/35430873
Autor:
Mark E. Rosenberg, Sharon Anderson, Samira S. Farouk, Keisha L. Gibson, Robert S. Hoover, Benjamin D. Humphreys, Janis M. Orlowski, Suneel M. Udani, Joshua S. Waitzman, Melissa West, Tod Ibrahim
Publikováno v:
Clinical Journal of the American Society of Nephrology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fa72769f854648aea0ed68dee679320
https://doi.org/10.2215/cjn.0000000000000133
https://doi.org/10.2215/cjn.0000000000000133
Autor:
Robert S. Hoover, Jia Xiao, Xiaonan H. Wang, Xinxin Chen, Haian Fu, Hui Cai, Shan Chen, Zhizhi Zhuang, Xiuyan Feng, Douglas C. Eaton, Janet D. Klein
Publikováno v:
American Journal of Physiology-Renal Physiology. 319:F52-F62
14-3-3γ is a small protein regulating its target proteins through binding to phosphorylated serine/threonine residues. Sequence analysis of large-conductance Ca2+-activated K+ (BK) channels revealed a putative 14-3-3 binding site in the COOH-termina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a2e9edcd40d98ac36354001a50b5f3b
https://doi.org/10.1152/ajprenal.00584.2019
https://doi.org/10.1152/ajprenal.00584.2019
Autor:
Robert S. Hoover, Aswathy M Cheriyan, Hui Cai, Clintoria R. Williams, Monisha Mistry, Carla LaShannon Ellis, Abinash C. Mistry, Jennifer L. Gooch, Benjamin Ko, Jasmine M. Williams, Meagan Naraine, Rickta Mallick
Publikováno v:
American Journal of Physiology-Renal Physiology. 316:F646-F653
Zn2+ deficiency (ZnD) is a common comorbidity of many chronic diseases. In these settings, ZnD exacerbates hypertension. Whether ZnD alone is sufficient to alter blood pressure (BP) is unknown. To explore the role of Zn2+ in BP regulation, adult mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26b8b2d10af966816e64e820bf00f4c3
https://doi.org/10.1152/ajprenal.00487.2018
https://doi.org/10.1152/ajprenal.00487.2018