Zobrazeno 1 - 10
of 420
pro vyhledávání: '"Robert S. Heyderman"'
Autor:
Grace Mzumara, James Chirombo, Todd D. Swarthout, Naor Bar-Zeev, Philliness Prisca Harawa, Mohamed Sanusi Jalloh, Amir Kirolos, Victoria Mukhula, Laura Newberry, Olawale Ogunlade, Richard Wachepa, Neil French, Robert S. Heyderman, Pui-Ying Iroh Tam
Publikováno v:
Pneumonia, Vol 16, Iss 1, Pp 1-6 (2024)
Abstract Background The 13-valent pneumococcal conjugate vaccine (PCV-13) was introduced in Malawi in 2011 with an expected impact of reducing pneumococcal pneumonia in children. We aimed to describe clinical characteristics and nasopharyngeal (NP) c
Externí odkaz:
https://doaj.org/article/24b8f96e80524f1080cc42b830c4b904
Autor:
Akuzike Kalizang’oma, Damien Richard, Brenda Kwambana-Adams, Juliana Coelho, Karen Broughton, Bruno Pichon, Katie L. Hopkins, Victoria Chalker, Sandra Beleza, Stephen D. Bentley, Chrispin Chaguza, Robert S. Heyderman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Streptococcus mitis is a leading cause of infective endocarditis (IE). However, our understanding of the genomic epidemiology and pathogenicity of IE-associated S. mitis is hampered by low IE incidence. Here we use whole genome sequencing of
Externí odkaz:
https://doaj.org/article/ca029c9f70b5483cb69b90e930dd5730
Autor:
Samuel Channon-Wells, Dominic Habgood-Coote, Ortensia Vito, Rachel Galassini, Victoria J. Wright, Andrew J. Brent, Robert S. Heyderman, Suzanne T. Anderson, Brian Eley, Federico Martinón-Torres, Michael Levin, Myrsini Kaforou, On behalf of UK Kawasaki Disease Genetics, ILULU, GENDRES and EUCLIDS consortia, Jethro A. Herberg
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background Whole blood host transcript signatures show great potential for diagnosis of infectious and inflammatory illness, with most published signatures performing binary classification tasks. Barriers to clinical implementation include v
Externí odkaz:
https://doaj.org/article/aa9f5af63b3447538a074a42a9b96c2b
Autor:
Jessie J. Khaki, James E. Meiring, Deus Thindwa, Marc Y. R. Henrion, Tikhala M. Jere, Harrison Msuku, The STRATAA Consortium, Robert S. Heyderman, Melita A. Gordon, Emanuele Giorgi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Salmonella Typhi is a human-restricted pathogen that is transmitted by the faecal–oral route and causative organism of typhoid fever. Using health facility data from 2016 to 2020, this study focuses on modelling the spatial variation in ty
Externí odkaz:
https://doaj.org/article/bfc7599682f54540afd606862ca1d403
Autor:
Nginache Nampota-Nkomba, Osward M. Nyirenda, Victoria Mapemba, Rhoda Masonga, Priyanka D. Patel, Theresa Misiri, Felistas Mwakiseghile, Richard Wachepa, John M. Ndaferankhande, Bright Lipenga, Pratiksha Patel, Happy Banda, Jennifer Oshinsky, Marcela F. Pasetti, Robert S. Heyderman, Leslie P. Jamka, Divya Hosangadi, Shrimati Datta, Melita A. Gordon, Kathleen M. Neuzil, Matthew B. Laurens
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 20, Iss 1 (2024)
Vaccine safety and immunogenicity data in human immunodeficiency virus (HIV)-exposed uninfected (HEU) children are important for decision-making in HIV and typhoid co-endemic countries. In an open-label study, we recruited Malawian HEU and HIV unexpo
Externí odkaz:
https://doaj.org/article/f07e042e084547c98e965b494eb39f5a
Autor:
Joseph Donovan, Abena Glover, John Gregson, Andrew W. Hitchings, Emma C. Wall, Robert S. Heyderman
Publikováno v:
BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background Neurological infection is an important cause of critical illness, yet little is known on the epidemiology of neurological infections requiring critical care. Methods We analysed data on all adults with proven or probable neurologi
Externí odkaz:
https://doaj.org/article/cbe5589be9cb4dc1b1bd490992b2d78d
Autor:
Uri Obolski, Todd D. Swarthout, Akuzike Kalizang’oma, Thandie S. Mwalukomo, Jia Mun Chan, Caroline M. Weight, Comfort Brown, Rory Cave, Jen Cornick, Arox Wadson Kamng’ona, Jacquline Msefula, Giuseppe Ercoli, Jeremy S. Brown, José Lourenço, Martin C. Maiden, Neil French, Sunetra Gupta, Robert S. Heyderman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Streptococcus pneumoniae causes substantial mortality among children under 5-years-old worldwide. Polysaccharide conjugate vaccines (PCVs) are highly effective at reducing vaccine serotype disease, but emergence of non-vaccine serotypes and
Externí odkaz:
https://doaj.org/article/91b8c2d41692430f887ad9109b2efaa9
Autor:
Regina E. Abotsi, Felix S. Dube, Andrea M. Rehman, Shantelle Claassen-Weitz, Yao Xia, Victoria Simms, Kilaza S. Mwaikono, Sugnet Gardner-Lubbe, Grace McHugh, Lucky G. Ngwira, Brenda Kwambana-Adams, Robert S. Heyderman, Jon Ø. Odland, Rashida A. Ferrand, Mark P. Nicol, The BREATHE study team
Publikováno v:
Microbiome, Vol 11, Iss 1, Pp 1-19 (2023)
Abstract Background Long-term azithromycin (AZM) treatment reduces the frequency of acute respiratory exacerbation in children and adolescents with HIV-associated chronic lung disease (HCLD). However, the impact of this treatment on the respiratory b
Externí odkaz:
https://doaj.org/article/1a6ecb8a819d4ea8b8d835d6cf70b4c3
Autor:
Deus Thindwa, Samuel Clifford, Jackie Kleynhans, Anne von Gottberg, Sibongile Walaza, Susan Meiring, Todd D. Swarthout, Elizabeth Miller, Peter McIntyre, Nick Andrews, Zahin Amin-Chowdhury, Norman Fry, Kondwani C. Jambo, Neil French, Samanta Cristine Grassi Almeida, Shamez N. Ladhani, Robert S. Heyderman, Cheryl Cohen, Maria Cristina de Cunto Brandileone, Stefan Flasche
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-8 (2023)
Vaccination against invasive pneumococcal disease is recommended for older adults but the optimal age group to target has not been determined and may vary by epidemiological setting. Here, the authors use statistical modelling to estimate the optimal
Externí odkaz:
https://doaj.org/article/46ec24eaffaa42cb9c48d6db1517712f
Autor:
Amir Kirolos, Todd D. Swarthout, Andrew A. Mataya, Farouck Bonomali, Comfort Brown, Jacquline Msefula, Naor Bar-Zeev, Pui-Ying Iroh Tam, Maaike Alaerts, Sithembile Bilima, Robert S. Heyderman, Neil French
Publikováno v:
BMC Infectious Diseases, Vol 23, Iss 1, Pp 1-7 (2023)
Abstract Introduction The introduction of PCV13 to the Malawi infant immunization schedule in 2011 has been associated with reduced disease from Streptococcus pneumoniae. Improved understanding of serotypes with high invasive potential can guide futu
Externí odkaz:
https://doaj.org/article/63167f6b39844ccaba2eed1a4eeaad19