Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Robert S. Foti"'
Autor:
Jeffrey R. Simard, Klaus Michelsen, Yan Wang, Chunhua Yang, Beth Youngblood, Barbara Grubinska, Kristin Taborn, Daniel J. Gillie, Kevin Cook, Kyu Chung, Alexander M. Long, Brian E. Hall, Paul L. Shaffer, Robert S. Foti, Jacinthe Gingras
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 383:56-69
Ion channels are targets of considerable therapeutic interest to address a wide variety of neurologic indications, including pain perception. Current pharmacological strategies have focused mostly on small molecule approaches that can be limited by s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4587f1dc532b800a2152c9df3276069
https://doi.org/10.1124/jpet.121.001026
https://doi.org/10.1124/jpet.121.001026
Autor:
Robert S. Foti
Publikováno v:
Drug Metabolism and Disposition. :DMD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87c13774fdfc405e31e2c903e8fbccfa
https://doi.org/10.1124/dmd.122.001011
https://doi.org/10.1124/dmd.122.001011
Autor:
John R, Butler, Gwenaella, Rescourio, Benjamin C, Milgram, Robert S, Foti, Thomas, Kornecook, Joseph, Ligutti, Bryan D, Moyer, Kristin, Taborn, Beth D, Youngblood, Violeta, Yu, Roman, Shimanovich, Alessandro, Boezio, Matthew, Weiss
Publikováno v:
Bioorganicmedicinal chemistry letters. 73
Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::026ead5bb43373a0b3209260097690d4
https://pubmed.ncbi.nlm.nih.gov/35850422
https://pubmed.ncbi.nlm.nih.gov/35850422
Autor:
Robert S. Foti
Publikováno v:
Reference Module in Biomedical Sciences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e44d01474aee74bc3c51f90576cd7e18
https://doi.org/10.1016/b978-0-12-820472-6.00141-9
https://doi.org/10.1016/b978-0-12-820472-6.00141-9
Autor:
Brad Herberich, Thomas Nixey, Lin Yin, Tayo Ikotun, Kelvin K. C. Sham, Jason Long, Hongyan Li, Charles Glaus, Xuhai Be, Les P. Miranda, Yuan Cheng, Marcus Soto, James R. Falsey, Bryan D. Moyer, Robert S. Foti, Christopher M. Tegley, Chawita Netirojjanakul, Linh Tran, Kip P. Conner, Jennifer Aral, Liyue Huang, Kaustav Biswas, Justin K. Murray, Bin Wu, Loren Berry, Dean Hickman, Dan A. Rock
Publikováno v:
Drug Metabolism and Disposition. 47:1111-1121
The identification of nonopioid alternatives to treat chronic pain has received a great deal of interest in recent years. Recently, the engineering of a series of Nav1.7 inhibitory peptide-antibody conjugates has been reported, and herein, the precli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aafa704103c2cd45fe6f198cffc5d5f
https://doi.org/10.1124/dmd.119.087742
https://doi.org/10.1124/dmd.119.087742
Autor:
Bryan D. Moyer, Brad Herberich, Kaustav Biswas, Kenneth W. Walker, Beth D. Youngblood, Jennifer Aral, Tayo Ikotun, Min-Hwa Jasmine Lin, Linh Tran, Thomas Kornecook, Hongyan Li, Thomas Nixey, Joseph Ligutti, Shanti Amagasu, Li Yin, Xuhai Be, Kristin L. Andrews, Christopher M. Tegley, Charles Glaus, Marcus Soto, Les P. Miranda, James R. Falsey, Jason Long, Yuan Cheng, Robert S. Foti, Hossein Salimi-Moosavi, Kelvin Sham, Christopher P Ilch, Bin Wu, Justin K. Murray, Margaret Karow, Chawita Netirojjanakul, Liz Doherty
Publikováno v:
ACS Chemical Biology. 14:806-818
Drug discovery research on new pain targets with human genetic validation, including the voltage-gated sodium channel NaV1.7, is being pursued to address the unmet medical need with respect to chronic pain and the rising opioid epidemic. As part of e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68d1aa4016111a37796e962e98dcd944
https://doi.org/10.1021/acschembio.9b00183
https://doi.org/10.1021/acschembio.9b00183
Autor:
Farah Al Qaraghuli, Ravindra Varma Alluri, Sophie M.A. Argon, Piyush Bajaj, Tashinga E. Bapiro, Abdul Basit, Andreas Brink, Tingting Cai, Jose Castro-Perez, Jae H. Chang, Eugene Chia-Te Chen, Marie Croft, Liam Evans, Raymond Evers, Robert S. Foti, Adrian J. Fretland, Christopher Gemski, Anima Ghosal, Jia Hao, Satyajeet Haridas, Simon Hauri, Nina Isoherranen, Wenying Jian, Kevin Johnson, Barry Jones, Robert S. Jones, Jan Felix Joseph, S. Cyrus Khojasteh, Yurong Lai, Hoa Le, Xiaomin Liang, Liming Liu, Filipe Lopes, Justin Q. Ly, Shuguang Ma, Roshini Markandu, Rosalinde Masereeuw, J. Eric McDuffie, Kaushik Mitra, Diana Montgomery, Alexandra L. Orton, Katie H. Owens, Axel Pähler, Maria Kristina Parr, Shefali Patel, Ichiko D. Petrie, Richard Phipps, Chandra Prakash, Bhagwat Prasad, Isabelle Ragueneau-Majlessi, Venkatesh Pilla Reddy, Ellen Riddle, Qian Ruan, Simone Schadt, Dhaval K. Shah, Julia Shanu-Wilson, Kelly MacLennan Staiger, Jonathan Steele, Manthena V.S. Varma, Matthew P. Wagoner, Naidong Weng, Stephen Wrigley, Caisheng Wu, Graeme C. Young, Jingjing Yu, Lushan Yu, Su Zeng, Haeyoung Zhang, Wanying Zhang, Andy Z.X. Zhu, Mingshe Zhu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32563bc881f8145ec2036a1b650e62de
https://doi.org/10.1016/b978-0-12-820018-6.09990-7
https://doi.org/10.1016/b978-0-12-820018-6.09990-7
Autor:
Robert S. Foti, Nina Isoherranen
The aim of this chapter is to illustrate the theory, concepts, and practices surrounding the in vitro characterization of drug-drug interactions and the subsequent prediction of in vivo drug interactions. More specific information can be found in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc6559a22d28139285ecf49fa32ff6e6
https://doi.org/10.1016/b978-0-12-820018-6.00009-0
https://doi.org/10.1016/b978-0-12-820018-6.00009-0
Autor:
Emily A. Peterson, Stephanie D. Geuns-Meyer, Matthew Weiss, Hongbing Huang, Katrina W. Copeland, Violeta Yu, Erin F. DiMauro, Hua Gao, Alessandro Boezio, Russell Graceffa, Daniel S. La, Hakan Gunaydin, Robert T. Fremeau, Christiane Boezio, Margaret Chu-Moyer, Joseph Ligutti, Bryan D. Moyer, Kristin L. Andrews, Robert S. Foti
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:2103-2108
Recently, the identification of several classes of aryl sulfonamides and acyl sulfonamides that potently inhibit NaV1.7 and demonstrate high levels of selectivity over other NaV isoforms have been reported. The fully ionizable nature of these inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::857963b5479482ddc3b3b092657acc77
https://doi.org/10.1016/j.bmcl.2018.04.035
https://doi.org/10.1016/j.bmcl.2018.04.035
Autor:
Mizuki Suzuki, Ronald L. Horst, Justina Calamia, Erin G. Schuetz, Kenneth E. Thummel, Timothy A. Thornton, Brian D. Chapron, Bhagwat Prasad, Chunying Gao, Robert S. Foti, Amarjit S. Chaudhry, Alenka Chapron, Ian H. de Boer, Qingcheng Mao, Timothy Wong, Zhican Wang, Katrina G. Claw
Publikováno v:
Drug Metabolism and Disposition. 46:367-379
Metabolism of 25-hydroxyvitamin D3 (25OHD3) plays a central role in regulating the biologic effects of vitamin D in the body. Although cytochrome P450–dependent hydroxylation of 25OHD3 has been extensively investigated, limited information is avail
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a1cd52d4b68f744f6714fb3a983a2c4
https://doi.org/10.1124/dmd.117.078428
https://doi.org/10.1124/dmd.117.078428