Výsledky vyhledávání - "Robert S. Flynn"

Insulin-like growth factor-binding protein-5 stimulates growth of human intestinal muscle cells by activation of Gαi3

Autor: Karnam S. Murthy, Robert S. Flynn, Sunila Mahavadi, John F. Kuemmerle, John M. Kellum

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 297:G1232-G1238

In human intestinal smooth muscle cells, endogenous insulin-like growth factor-I (IGF-I) regulates growth and IGF-binding protein-5 (IGFBP-5) expression. The effects of IGF-I are facilitated by IGFBP-5. We previously showed that IGFBP-5 acts independ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0429f0d82488541781e551d784dc409d
https://doi.org/10.1152/ajpgi.00323.2009

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Endogenous IGF-I and αvβ3 integrin ligands regulate increased smooth muscle growth in TNBS-induced colitis

Autor: John R. Grider, John F. Kuemmerle, Krystina B. Hazelgrove, Robert S. Flynn, Li-Ya Qiao

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 296:G1230-G1237

Endogenous insulin-like growth factor-I (IGF-I) regulates intestinal smooth muscle growth by concomitantly stimulating proliferation and inhibiting apoptosis. IGF-I-stimulated growth is augmented by the αvβ3 integrin ligands vitronectin and fibrone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::432ef7f1332d3fcac702806b35f8ee3a
https://doi.org/10.1152/ajpgi.90508.2008

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Increased Activation of Latent TGF-β1 by αVβ3 in Human Crohn’s Disease and Fibrosis in TNBS Colitis Can Be Prevented by Cilengitide

Autor: John R. Grider, John F. Kuemmerle, John M. Kellum, Robert S. Flynn, Chao Li, Homayoon Akbari, Karnam S. Murthy

Background: Strictures develop in .30% of patients affected with Crohn’s disease. No available medication prevents stricture development in susceptible patients. In Crohn’s strictures, but not adjacent normal intestine, TGF-b1 increases in muscul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdf8c437f21e65655de3916c371d1ca8
https://europepmc.org/articles/PMC3889641/

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Endogenous IGFBP-3 Regulates Excess Collagen Expression in Intestinal Smooth Muscle Cells of Crohn’s Disease Strictures

Autor: Robert S. Flynn, Sunila Mahavadi, Homayoon Akbari, John F. Kuemmerle, John M. Kellum, Karnam S. Murthy, John R. Grider

Crohn’s disease (CD) is characterized by three pathophysiologic changes within the smooth muscle of the muscularis propria of the intestine that contribute to stricture formation in the ≈30% of patients who experience this complication.1,2 Strict

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d274c35e02598b6530318e361c95e3a3
https://europepmc.org/articles/PMC4863983/

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Amelioration of excess collagen IαI, fibrosis, and smooth muscle growth in TNBS-induced colitis in IGF-I(+/-) mice

Autor: John R. Grider, John F. Kuemmerle, Li-Ya Qiao, Robert S. Flynn, Sunila Mahavadi, Krystina B. Hazelgrove, Karnam S. Murthy

Publikováno v: Inflammatory bowel diseases. 17(3)

Background: Strictures occur in ≈30% of patients with Crohn's disease (CD) and are characterized by intestinal smooth muscle hyperplasia, hypertrophy, and fibrosis due to excess extracellular matrix production including collagen. Insulin-like growt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::171679f8c8324834aa49cfcd2c3ee7b9
https://pubmed.ncbi.nlm.nih.gov/20722057

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Endogenous IGF-I and αVβ3 Integrin Ligands Regulate the Increased Smooth Muscle Hyperplasia of Stricturing Crohn's Disease

Autor: John R. Grider, John M. Kellum, John F. Kuemmerle, Karnam S. Murthy, Robert S. Flynn

Background & Aims Insulin-like growth factor-I (IGF-I) regulates human intestinal smooth muscle growth by stimulating proliferation and inhibiting apoptosis. IGF-I-stimulated growth is augmented when αVβ3 integrin is occupied by its ligands, fibron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b56e5181a86438ecae49898a01ec040a
https://europepmc.org/articles/PMC2813387/

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Cilengitide Blocks αVβ3 Integrin-Mediated, Rgd-Dependent Activation of Latent TGF-β1 and Attenuates Fibrosis in TNBS-Induced Colitis and Human Muscle of Stricturing Crohn's Disease

Autor: John R. Grider, Zachary L. Bradley, John F. Kuemmerle, Karnam S. Murthy, Robert S. Flynn

Publikováno v: Gastroenterology. 140:S-109

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d41ebe38f8ddd20acb8c7a3ebd1c763
https://doi.org/10.1016/s0016-5085(11)60442-3

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T1680 Endogenous IGFBP-3 Activates TGF-βRi/II Receptors and SMAD3-Dependent Collagen I Expression and Production in Human Intestinal Smooth Muscle Cells

Autor: John F. Kuemmerle, Robert S. Flynn

Publikováno v: Gastroenterology. 136:A-556

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c0736748ade43b64ed17ec084e5eb9df
https://doi.org/10.1016/s0016-5085(09)62560-9

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W1180 Endogenous IGFBP-3 Activates TGF-β Receptors and Regulates Type I Collagen Expression and Production in Human Intestinal Smooth Muscle Cells in Crohn's Disease

Autor: Jennifer G. Bowers, Robert S. Flynn, John F. Kuemmerle

Publikováno v: Gastroenterology. 134:A-650

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7de5e1646bf68cde42611b1b08208873
https://doi.org/10.1016/s0016-5085(08)63032-2

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