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pro vyhledávání: '"Robert S. Dawber"'
Autor:
Joanna Bonnici, Razanne Oueini, Eidarus Salah, Catrine Johansson, Elisabete Pires, Martine Abboud, Robert S. Dawber, Anthony Tumber, Patrick Rabe, Hilal Saraç, Christopher J. Schofield, Akane Kawamura
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract 2-Oxoglutarate (2OG) dependent N ε -methyl lysine demethylases (JmjC-KDMs) regulate eukaryotic transcription. We report studies showing that isolated forms of all human KDM4 and KDM5 JmjC enzymes catalyse demethylation of N-methylated Arg-3
Externí odkaz:
https://doaj.org/article/05b29963e9554ce083ab7680ddbc74cd
Publikováno v:
Chemical Science
Protein–protein interactions (PPIs) are implicated in the majority of cellular processes by enabling and regulating the function of individual proteins. Thus, PPIs represent high-value, but challenging targets for therapeutic intervention. The deve