Zobrazeno 1 - 10
of 223
pro vyhledávání: '"Robert S. Coleman"'
Publikováno v:
The Journal of Organic Chemistry. 72:8724-8736
Full details of the total syntheses of five members of the eupomatilone family of lignans are reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3384a2345e78265a1cecbfa986330ea
https://doi.org/10.1021/jo701415m
https://doi.org/10.1021/jo701415m
Publikováno v:
The Journal of Organic Chemistry. 72:7726-7735
The design and synthesis of a detailed series of functional "top-half" substructures of azinomycin A and B is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d3e0e6f9b3ec8b6b62ebdc157aa2d0
https://doi.org/10.1021/jo7014888
https://doi.org/10.1021/jo7014888
Publikováno v:
e-EROS Encyclopedia of Reagents for Organic Synthesis
[201551-23-7] C18H20N4O2 (MW 324.38) InChI = 1S/C18H20N4O2/c23-17(15-9-3-5-11-19-15)21-13-7-1-2-8-14(13)22-18(24)16-10-4-6-12-20-16/h3-6,9-14H,1-2,7-8H2,(H,21,23)(H,22,24)/t13-,14-/m1/s1 InChIKey = BVYFDUZVVBXFBQ-ZIAGYGMSSA-N (chiral bis-picolinic am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07b441826a205b6448197816630bce81
https://doi.org/10.1002/047084289x.rn00209.pub2
https://doi.org/10.1002/047084289x.rn00209.pub2
Autor:
Robert S. Coleman, Matthew C. Walczak
Publikováno v:
The Journal of Organic Chemistry. 71:9841-9844
Convergent and efficient syntheses of the microbial natural products gymnoconjugatin A and B are reported and were based on a linchpin coupling strategy using a boron/tin hetero-bis-metallated butadiene system.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d97edcf09f69b814d5ea5793fb9e23bf
https://doi.org/10.1021/jo061755c
https://doi.org/10.1021/jo061755c
Publikováno v:
The Journal of Organic Chemistry. 71:8059-8070
Application of photoinduced acylnitrene aziridination to the syntheses of L-daunosamine and L-ristosamine glycosides is reported. Photoreaction of methyl 4-O-azidocarbonyl-2,3,6-trideoxy- L-hex-2-enopyranosides, followed by aziridine opening, leads t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89ab48c1f91b4be7ec7644761e1ff766
https://doi.org/10.1021/jo061167z
https://doi.org/10.1021/jo061167z
Autor:
Sobhan Sen, Robert S. Coleman, Hai Liu, Latha A. Gearheart, Mark A. Berg, Catherine J. Murphy, Evan Rivers
Publikováno v:
The Journal of Physical Chemistry B. 110:13248-13255
This paper examines the contribution of counterion motion to the electric-field dynamics in the interior of DNA. The electric field is measured by a coumarin fluorophore that is synthetically incorporated into an oligonucleotide, where it replaces a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c68ed155b92008d23164bf886b27bb9
https://doi.org/10.1021/jp056327+
https://doi.org/10.1021/jp056327+
Publikováno v:
Chemistry & Biology. 13(5):485-492
SummaryStudies on the mechanism of action of the antitumor agent azinomycin B in vitro suggest that the drug elicits its lethal effects by the formation of interstrand crosslinks within the major groove of DNA. Here, we demonstrate the biological eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::353a6336f425d55f0d55626e2d9f6ec6
Autor:
Mark A. Berg, Robert S. Coleman, Michael D. Wyatt, Latha A. Gearheart, Ellen E. Connor, Ala Issa, David M. Wilson, Nicole A. Paraggio, Sobhan Sen
Publikováno v:
Biophysical Journal. 89:4129-4138
Synthetic oligonucleotides with a fluorescent coumarin group replacing a basepair have been used in recent time-resolved Stokes-shift experiments to measure DNA dynamics on the femtosecond to nanosecond timescales. Here, we show that the APE1 endonuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd0a4a2905c81c0b8104061db05640c
https://doi.org/10.1529/biophysj.105.062695
https://doi.org/10.1529/biophysj.105.062695
Publikováno v:
Journal of Chemical Information and Modeling. 45:602-609
In this work, we present molecular modeling studies carried out using six DNA sequences and six azinomycin analogues, including the naturally occurring compound azinomycin B, selected on the basis of known cell cytotoxicity and structural analogies (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21d8b8599c8ebeeaabe9da1fee46caa9
https://doi.org/10.1021/ci0496595
https://doi.org/10.1021/ci0496595
Publikováno v:
Organic Letters. 7:1849-1852
[structure: see text] Asymmetric total syntheses of the dibenzocyclooctadiene lignans interiotherin A and angeloylgomisin R are reported. The syntheses were based on an atropdiastereoselective, copper-promoted biaryl coupling reaction, a diastereosel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a58ce3d8454d863f33fde28b9a14007c
https://doi.org/10.1021/ol050476t
https://doi.org/10.1021/ol050476t