Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations

Autor: Minta Thomas, Yu-Ru Su, Elisabeth A. Rosenthal, Lori C. Sakoda, Stephanie L. Schmit, Maria N. Timofeeva, Zhishan Chen, Ceres Fernandez-Rozadilla, Philip J. Law, Neil Murphy, Robert Carreras-Torres, Virginia Diez-Obrero, Franzel J. B. van Duijnhoven, Shangqing Jiang, Aesun Shin, Alicja Wolk, Amanda I. Phipps, Andrea Burnett-Hartman, Andrea Gsur, Andrew T. Chan, Ann G. Zauber, Anna H. Wu, Annika Lindblom, Caroline Y. Um, Catherine M. Tangen, Chris Gignoux, Christina Newton, Christopher A. Haiman, Conghui Qu, D. Timothy Bishop, Daniel D. Buchanan, David R. Crosslin, David V. Conti, Dong-Hyun Kim, Elizabeth Hauser, Emily White, Erin Siegel, Fredrick R. Schumacher, Gad Rennert, Graham G. Giles, Heather Hampel, Hermann Brenner, Isao Oze, Jae Hwan Oh, Jeffrey K. Lee, Jennifer L. Schneider, Jenny Chang-Claude, Jeongseon Kim, Jeroen R. Huyghe, Jiayin Zheng, Jochen Hampe, Joel Greenson, John L. Hopper, Julie R. Palmer, Kala Visvanathan, Keitaro Matsuo, Koichi Matsuda, Keum Ji Jung, Li Li, Loic Le Marchand, Ludmila Vodickova, Luis Bujanda, Marc J. Gunter, Marco Matejcic, Mark A. Jenkins, Martha L. Slattery, Mauro D’Amato, Meilin Wang, Michael Hoffmeister, Michael O. Woods, Michelle Kim, Mingyang Song, Motoki Iwasaki, Mulong Du, Natalia Udaltsova, Norie Sawada, Pavel Vodicka, Peter T. Campbell, Polly A. Newcomb, Qiuyin Cai, Rachel Pearlman, Rish K. Pai, Robert E. Schoen, Robert S. Steinfelder, Robert W. Haile, Rosita Vandenputtelaar, Ross L. Prentice, Sébastien Küry, Sergi Castellví-Bel, Shoichiro Tsugane, Sonja I. Berndt, Soo Chin Lee, Stefanie Brezina, Stephanie J. Weinstein, Stephen J. Chanock, Sun Ha Jee, Sun-Seog Kweon, Susan Vadaparampil, Tabitha A. Harrison, Taiki Yamaji, Temitope O. Keku, Veronika Vymetalkova, Volker Arndt, Wei-Hua Jia, Xiao-Ou Shu, Yi Lin, Yoon-Ok Ahn, Zsofia K. Stadler, Bethany Van Guelpen, Cornelia M. Ulrich, Elizabeth A. Platz, John D. Potter, Christopher I. Li, Reinier Meester, Victor Moreno, Jane C. Figueiredo, Graham Casey, Iris Lansdorp Vogelaar, Malcolm G. Dunlop, Stephen B. Gruber, Richard B. Hayes, Paul D. P. Pharoah, Richard S. Houlston, Gail P. Jarvik, Ian P. Tomlinson, Wei Zheng, Douglas A. Corley, Ulrike Peters, Li Hsu

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)

Abstract Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal pe

Externí odkaz: https://doaj.org/article/e7a280372db24e62a96e2b247dd52766

Association between germline variants and somatic mutations in colorectal cancer

Autor: Richard Barfield, Conghui Qu, Robert S. Steinfelder, Chenjie Zeng, Tabitha A. Harrison, Stefanie Brezina, Daniel D. Buchanan, Peter T. Campbell, Graham Casey, Steven Gallinger, Marios Giannakis, Stephen B. Gruber, Andrea Gsur, Li Hsu, Jeroen R. Huyghe, Victor Moreno, Polly A. Newcomb, Shuji Ogino, Amanda I. Phipps, Martha L. Slattery, Stephen N. Thibodeau, Quang M. Trinh, Amanda E. Toland, Thomas J. Hudson, Wei Sun, Syed H. Zaidi, Ulrike Peters

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)

Abstract Colorectal cancer (CRC) is a heterogeneous disease with evidence of distinct tumor types that develop through different somatically altered pathways. To better understand the impact of the host genome on somatically mutated genes and pathway

Externí odkaz: https://doaj.org/article/58cb39ba742340a5ae919a4c19e2c19b

Genome-wide association study identifies tumor anatomical site-specific risk variants for colorectal cancer survival

Autor: Julia D. Labadie, Sevtap Savas, Tabitha A. Harrison, Barb Banbury, Yuhan Huang, Daniel D. Buchanan, Peter T. Campbell, Steven J. Gallinger, Graham G. Giles, Marc J. Gunter, Michael Hoffmeister, Li Hsu, Mark A. Jenkins, Yi Lin, Shuji Ogino, Amanda I. Phipps, Martha L. Slattery, Robert S. Steinfelder, Wei Sun, Bethany Van Guelpen, Xinwei Hua, Jane C. Figuieredo, Rish K. Pai, Rami Nassir, Lihong Qi, Andrew T. Chan, Ulrike Peters, Polly A. Newcomb

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)

Abstract Identification of new genetic markers may improve the prediction of colorectal cancer prognosis. Our objective was to examine genome-wide associations of germline genetic variants with disease-specific survival in an analysis of 16,964 cases

Externí odkaz: https://doaj.org/article/e0cd1a5fbff641d297b2c3ffd001479d

Data from Intake of Dietary Fruit, Vegetables, and Fiber and Risk of Colorectal Cancer According to Molecular Subtypes: A Pooled Analysis of 9 Studies

Autor: Ulrike Peters, Peter T. Campbell, Daniel D. Buchanan, Li Hsu, Wei Sun, Michael Hoffmeister, Stephen N. Thibodeau, Bethany Van Guelpen, Michael O. Woods, Xiaoliang Wang, Caroline Y. Um, Robert S. Steinfelder, Martha L. Slattery, John D. Potter, Patrick S. Parfrey, Mireia Obón-Santacana, Shuji Ogino, Reiko Nishihara, Polly A. Newcomb, Victor Moreno, Yi Lin, Mark A. Jenkins, Heather Hampel, Sophia Harlid, Mark A. Guinter, Marc J. Gunter, Steven Gallinger, Andrew T. Chan, Ivan Borozan, Sonja I. Berndt, Efrat L. Amitay, Amanda E. Toland, Syed H. Zaidi, Jane C. Figueiredo, Amanda I. Phipps, Mingyang Song, Marios Giannakis, Richard Barfield, Lori C. Sakoda, Yin Cao, Tabitha A. Harrison, Akihisa Hidaka

Protective associations of fruits, vegetables, and fiber intake with colorectal cancer risk have been shown in many, but not all epidemiologic studies. One possible reason for study heterogeneity is that dietary factors may have distinct effects by c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78a5a91cc8f58c76b6b865e9f73fe0ed
https://doi.org/10.1158/0008-5472.c.6512209

Combining Asian-European Genome-Wide Association Studies of Colorectal Cancer Improves Risk Prediction Across Race and Ethnicity

Autor: Minta Thomas, Yu-Ru Su, Elisabeth A. Rosenthal, Lori C Sakoda, Stephanie L Schmit, Maria N Timofeeva, Zhishan Chen, Ceres Fernandez-Rozadilla, Philip J Law, Neil Murphy, Robert Carreras-Torres, Virginia Diez-Obrero, Franzel JB van Duijnhoven, Shangqing Jiang, Aesun Shin, Alicja Wolk, Amanda I Phipps, Andrea Burnett-Hartman, Andrea Gsur, Andrew T Chan, Ann G Zauber, Anna H Wu, Annika Lindblom, Caroline Y Um, Catherine M Tangen, Chris Gignoux, Christina Newton, Christopher A. Haiman, Conghui Qu, D Timothy Bishop, Daniel D Buchanan, David R. Crosslin, David V Conti, Dong-Hyun Kim, Elizabeth Hauser, Emily White, Erin Siegel, Fredrick R Schumacher, Gad Rennert, Graham G Giles, Heather Hampel, Hermann Brenner, Isao Oze, Jae Hwan Oh, Jeffrey K Lee, Jennifer L Schneider, Jenny Chang-Claude, Jeongseon Kim, Jeroen R Huyghe, Jiayin Zheng, Jochen Hampe, Joel Greenson, John L Hopper, Julie R Palmer, Kala Visvanathan, Keitaro Matsuo, Koichi Matsuda, Keum Ji Jung, Li Li, Loic Le Marchand, Ludmila Vodickova, Luis Bujanda, Marc J Gunter, Marco Matejcic, Mark A Jenkins, Martha L Slattery, Mauro D’Amato, Meilin Wang, Michael Hoffmeister, Michael O Woods, Michelle Kim, Mingyang Song, Motoki Iwasaki, Mulong Du, Natalia Udaltsova, Norie Sawada, Pavel Vodicka, Peter T Campbell, Polly A Newcomb, Qiuyin Cai, Rachel Pearlman, Rish K Pai, Robert E Schoen, Robert S Steinfelder, Robert W Haile, Rosita Vandenputtelaar, Ross L Prentice, Sébastien Küry, Sergi Castellví-Bel, Shoichiro Tsugane, Sonja I Berndt, Soo Chin Lee, Stefanie Brezina, Stephanie J Weinstein, Stephen J Chanock, Sun Ha Jee, Sun-Seog Kweon, Susan Vadaparampil, Tabitha A Harrison, Taiki Yamaji, Temitope O Keku, Veronika Vymetalkova, Volker Arndt, Wei-Hua Jia, Xiao-Ou Shu, Yi Lin, Yoon-Ok Ahn, Zsofia K Stadler, Bethany Van Guelpen, Cornelia M Ulrich, Elizabeth A Platz, John D Potter, Christopher I Li, Reinier Meester, Victor Moreno, Jane C Figueiredo, Graham Casey, Iris Landorp Vogelaar, Malcolm G Dunlop, Stephen B Gruber, Richard B Hayes, Paul D P Pharoah, Richard S Houlston, Gail P Jarvik, Ian P Tomlinson, Wei Zheng, Douglas A Corley, Ulrike Peters, Li Hsu

Publikováno v: medRxiv

Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal performance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf06a412fb514674d86ced441c25f727
https://europepmc.org/articles/PMC9928144/