Zobrazeno 1 - 10
of 475
pro vyhledávání: '"Robert S Negrin"'
Autor:
Emanuela I Sega, Dennis B Leveson-Gower, Mareike Florek, Dominik Schneidawind, Richard H Luong, Robert S Negrin
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86551 (2014)
Lag-3 has emerged as an important molecule in T cell biology. We investigated the role of Lag-3 in conventional T cell (Tcon) and regulatory T cell (Treg) function in murine GVHD with the hypothesis that Lag-3 engagement diminishes alloreactive T cel
Externí odkaz:
https://doaj.org/article/a0faece07ceb4400b242bf8d6059b24b
Autor:
Chaiyaporn Boonchalermvichian, Hao Yan, Biki Gupta, Anabel Rubin, Jeanette Baker, Robert S. Negrin
Publikováno v:
Frontiers in Transplantation, Vol 3 (2024)
Invariant Natural Killer T cell therapy is an emerging platform of immunotherapy for cancer treatment. This unique cell population is a promising candidate for cell therapy for cancer treatment because of its inherent cytotoxicity against CD1d positi
Externí odkaz:
https://doaj.org/article/36497f25a3124e689c483e2eaa1e3f9e
Autor:
Michael A. Spinner, Vanessa E. Kennedy, John S. Tamaresis, Philip W. Lavori, Sally Arai, Laura J. Johnston, Everett H. Meyer, David B. Miklos, Lori S. Muffly, Robert S. Negrin, Andrew R. Rezvani, Judith A. Shizuru, Wen-Kai Weng, Richard T. Hoppe, Samuel Strober, Robert Lowsky
Publikováno v:
Blood Advances, Vol 3, Iss 16, Pp 2454-2464 (2019)
Abstract: Nonmyeloablative total lymphoid irradiation and antithymocyte globulin (TLI-ATG) conditioning is protective against graft-versus-host disease (GVHD), while retaining graft-versus-tumor activity across various hematologic malignancies. We re
Externí odkaz:
https://doaj.org/article/43899d6eaf0e47758cc194b59604146d
Autor:
Teresa L. Ramos, Sara Bolivar-Wagers, Sujeong Jin, Govindarajan Thangavelu, Federico Simonetta, Po-Yu Lin, Toshihito Hirai, Asim Saha, Brent Koehn, Leon L. Su, Lora K. Picton, Jeanette Baker, Juliane K. Lohmeyer, Megan Riddle, Cindy Eide, Jakub Tolar, Angela Panoskaltsis-Mortari, John E. Wagner, K. Christopher Garcia, Robert S. Negrin, Bruce R. Blazar
Publikováno v:
Blood. 141:1337-1352
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative option for patients with hematological disorders and bone marrow (BM) failure syndromes. Graft-versus-host disease (GVHD) remains a leading cause of morbidity posttransplant
Autor:
Maite Alvarez, Federico Simonetta, Jeanette Baker, Alyssa R. Morrison, Arielle S. Wenokur, Antonio Pierini, Pedro Berraondo, Robert S. Negrin
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The induction of exhaustion on effector immune cells is an important limiting factor for cancer immunotherapy efficacy as these cells undergo a hierarchical loss of proliferation and cytolytic activity due to chronic stimulation. Targeting PD-1 has s
Externí odkaz:
https://doaj.org/article/2071fc1f28184b3dbb6e88d80192e410
Autor:
Lori Muffly, Kevin Sheehan, Randall Armstrong, Kent Jensen, Keri Tate, Andrew R. Rezvani, David Miklos, Sally Arai, Judith Shizuru, Laura Johnston, Everett Meyer, Wen-Kai Weng, Ginna G. Laport, Robert S. Negrin, Sam Strober, Robert Lowsky
Publikováno v:
Blood Advances, Vol 2, Iss 6, Pp 681-690 (2018)
Abstract: Murine models showed that CD8+CD44hi memory T (TM) cells could eradicate malignant cells without inducing graft-versus-host disease (GVHD). We evaluated the feasibility and safety of infusing freshly isolated and purified donor-derived phen
Externí odkaz:
https://doaj.org/article/f0bc4eb8fa2941cba79dfad961baa96b
Autor:
Zunyu Xiao, Israt S. Alam, Federico Simonetta, Weiyu Chen, Lukas Scheller, Surya Murty, Juliane K. Lohmeyer, Teresa L. Ramos, Michelle L. James, Robert S. Negrin, Sanjiv S. Gambhir
Publikováno v:
Blood Advances. 6:4782-4792
Allogeneic hematopoietic cell transplantation (HCT) is a well-established and potentially curative treatment for a broad range of hematological diseases, bone marrow failure states, and genetic disorders. Acute graft-versus-host disease (GvHD), media
Autor:
Vijith Vijayan, Hao Yan, Juliane K. Lohmeyer, Kaylin A. Prentiss, Rachna V. Patil, Giulia Barbarito, Ivan Lopez, Aly Elezaby, Kolten Peterson, Jeanette Baker, Nicolai P. Ostberg, Alice Bertaina, Robert S. Negrin, Daria Mochly-Rosen, Kenneth Weinberg, Bereketeab Haileselassie
Despite therapeutic advancements, graft versus host disease (GVHD) is a major complication of hematopoietic stem cell transplantation (HSCT). Pathogen and damage associated molecular patterns released following pre-transplant conditioning play an imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3596c5bfb77912505ae22d6eb3ee9427
https://doi.org/10.1101/2023.04.24.538141
https://doi.org/10.1101/2023.04.24.538141
Autor:
Michael A. Spinner, Marcelo Fernández-Viña, Lisa E. Creary, Olivia Quinn, Linda Elder, Sally Arai, Laura J. Johnston, Everett H. Meyer, David B. Miklos, Lori S. Muffly, Robert S. Negrin, Judith A. Shizuru, Wen-Kai Weng, Ginna G. Laport, Samuel Strober, Robert Lowsky, Andrew R. Rezvani
Publikováno v:
Blood Advances, Vol 1, Iss 17, Pp 1347-1357 (2017)
Abstract: Many patients lack a fully HLA-matched donor for hematopoietic cell transplantation (HCT), and HLA mismatch is typically associated with inferior outcomes. Total lymphoid irradiation and antithymocyte globulin (TLI-ATG) is a nonmyeloablativ
Externí odkaz:
https://doaj.org/article/67a43573dd224658960f49adfc9ca942
Autor:
Shona Philip, Robert Lowsky, Laura J. Johnston, Sally Arai, Everett H. Meyer, Robert S. Negrin, Andrew R. Rezvani, Parveen Shiraz, Judith A. Shizuru, Surbhi Sidana, Wen-Kai Weng, Sushma Bharadwaj, Matthew J. Frank, David B. Miklos, Melody Smith, Lori Muffly, Vaibhav Agrawal
Publikováno v:
Blood. 140:4825-4827